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SMCO2 single-pass membrane protein with coiled-coil domains 2 [ Homo sapiens (human) ]

Gene ID: 341346, updated on 26-Oct-2022

Summary

Official Symbol
SMCO2provided by HGNC
Official Full Name
single-pass membrane protein with coiled-coil domains 2provided by HGNC
Primary source
HGNC:HGNC:34448
See related
Ensembl:ENSG00000165935 AllianceGenome:HGNC:34448
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C12orf70
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See SMCO2 in Genome Data Viewer
Location:
12p11.23
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (27423316..27502185)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (27318406..27373856)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (27599669..27655118)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902905 Neighboring gene serine/threonine kinase 38 like Neighboring gene uncharacterized LOC124902906 Neighboring gene basic helix-loop-helix ARNT like 2 Neighboring gene BMAL2 antisense RNA 1 Neighboring gene arginyl-tRNA synthetase 1 pseudogene 1 Neighboring gene PPFIA binding protein 1 Neighboring gene Sharpr-MPRA regulatory region 6326 Neighboring gene chromosome 12 open reading frame 71B, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
single-pass membrane and coiled-coil domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145010.3NP_001138482.1  single-pass membrane and coiled-coil domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001138482.1

    Status: VALIDATED

    Source sequence(s)
    AC068794
    Consensus CDS
    CCDS44852.1
    UniProtKB/Swiss-Prot
    A6NFE2
    Related
    ENSP00000298876.4, ENST00000298876.8
    Conserved Domains (1) summary
    pfam14992
    Location:12342
    TMCO5; TMCO5 family
  2. NM_001387218.3NP_001374147.1  single-pass membrane and coiled-coil domain-containing protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC068794
    Consensus CDS
    CCDS91667.1
    Related
    ENSP00000513681.1, ENST00000698358.1
    Conserved Domains (1) summary
    pfam14992
    Location:75213
    TMCO5; TMCO5 family
  3. NM_001395208.2NP_001382137.1  single-pass membrane and coiled-coil domain-containing protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC068794
    Consensus CDS
    CCDS44852.1
    UniProtKB/Swiss-Prot
    A6NFE2
    Related
    ENSP00000441688.1, ENST00000535986.2
    Conserved Domains (1) summary
    pfam14992
    Location:12342
    TMCO5; TMCO5 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    27423316..27502185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047428776.1XP_047284732.1  single-pass membrane and coiled-coil domain-containing protein 2 isoform X2

  2. XM_047428775.1XP_047284731.1  single-pass membrane and coiled-coil domain-containing protein 2 isoform X1

    UniProtKB/Swiss-Prot
    A6NFE2
    Conserved Domains (1) summary
    pfam14992
    Location:12342
    TMCO5; TMCO5 family
  3. XM_017019254.2XP_016874743.1  single-pass membrane and coiled-coil domain-containing protein 2 isoform X3

    Conserved Domains (1) summary
    pfam14992
    Location:91263
    TMCO5; TMCO5 family
  4. XM_011520636.3XP_011518938.1  single-pass membrane and coiled-coil domain-containing protein 2 isoform X4

    Conserved Domains (1) summary
    pfam14992
    Location:13176
    TMCO5; TMCO5 family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    27318406..27373856
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)