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SMCO2 single-pass membrane protein with coiled-coil domains 2 [ Homo sapiens (human) ]

Gene ID: 341346, updated on 5-Jan-2022

Summary

Official Symbol
SMCO2provided by HGNC
Official Full Name
single-pass membrane protein with coiled-coil domains 2provided by HGNC
Primary source
HGNC:HGNC:34448
See related
Ensembl:ENSG00000165935
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C12orf70
Summary
Predicted to be integral component of membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See SMCO2 in Genome Data Viewer
Location:
12p11.23
Exon count:
11
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (27446482..27506911)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (27599669..27655118)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 38 like Neighboring gene aryl hydrocarbon receptor nuclear translocator like 2 Neighboring gene ARNTL2 antisense RNA 1 Neighboring gene arginyl-tRNA synthetase 1 pseudogene 1 Neighboring gene PPFIA binding protein 1 Neighboring gene Sharpr-MPRA regulatory region 6326 Neighboring gene uncharacterized protein C12orf71-like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
single-pass membrane and coiled-coil domain-containing protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145010.3NP_001138482.1  single-pass membrane and coiled-coil domain-containing protein 2 isoform 1

    See identical proteins and their annotated locations for NP_001138482.1

    Status: VALIDATED

    Source sequence(s)
    AC068794
    Consensus CDS
    CCDS44852.1
    UniProtKB/Swiss-Prot
    A6NFE2
    Related
    ENSP00000387617.1, ENST00000416383.5
    Conserved Domains (1) summary
    pfam14992
    Location:12342
    TMCO5; TMCO5 family
  2. NM_001387218.3NP_001374147.1  single-pass membrane and coiled-coil domain-containing protein 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC068794
    Conserved Domains (1) summary
    pfam14992
    Location:75213
    TMCO5; TMCO5 family
  3. NM_001395208.2NP_001382137.1  single-pass membrane and coiled-coil domain-containing protein 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC068794
    Related
    ENSP00000441688.1, ENST00000535986.1
    Conserved Domains (1) summary
    pfam14992
    Location:12342
    TMCO5; TMCO5 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    27446482..27506911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017019254.1XP_016874743.1  single-pass membrane and coiled-coil domain-containing protein 2 isoform X2

    Conserved Domains (1) summary
    pfam14992
    Location:91263
    TMCO5; TMCO5 family
  2. XM_011520636.2XP_011518938.1  single-pass membrane and coiled-coil domain-containing protein 2 isoform X4

    Conserved Domains (1) summary
    pfam14992
    Location:13176
    TMCO5; TMCO5 family
  3. XM_011520635.2XP_011518937.1  single-pass membrane and coiled-coil domain-containing protein 2 isoform X2

    Conserved Domains (1) summary
    pfam14992
    Location:91263
    TMCO5; TMCO5 family
  4. XM_024448967.1XP_024304735.1  single-pass membrane and coiled-coil domain-containing protein 2 isoform X2

    Conserved Domains (1) summary
    pfam14992
    Location:91263
    TMCO5; TMCO5 family
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