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OR2AT4 olfactory receptor family 2 subfamily AT member 4 [ Homo sapiens (human) ]

Gene ID: 341152, updated on 2-Nov-2024

Summary

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Official Symbol
OR2AT4provided by HGNC
Official Full Name
olfactory receptor family 2 subfamily AT member 4provided by HGNC
Primary source
HGNC:HGNC:19620
See related
Ensembl:ENSG00000171561 AllianceGenome:HGNC:19620
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR11-265
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See OR2AT4 in Genome Data Viewer
Location:
11q13.4
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (75081753..75096890, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (75011299..75026436, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (74792798..74807935, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily AT member 2 pseudogene Neighboring gene nucleophosmin 1 pseudogene 50 Neighboring gene CRISPRi-validated cis-regulatory element chr11.4261 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:74810905-74812104 Neighboring gene FA complementation group L pseudogene Neighboring gene olfactory receptor family 2 subfamily AT member 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Preliminary evidence that Merkel cells exert chemosensory functions in human epidermis. Piccini I, et al. Exp Dermatol, 2023 Oct. PMID 37587642
  2. Olfactory receptor OR2AT4 regulates human hair growth. Chéret J, et al. Nat Commun, 2018 Sep 18. PMID 30228264, Free PMC Article
  3. A synthetic sandalwood odorant induces wound-healing processes in human keratinocytes via the olfactory receptor OR2AT4. Busse D, et al. J Invest Dermatol, 2014 Nov. PMID 24999593
  4. Identification of Key Biomarkers and Immune Infiltration in Sporadic Vestibular Schwannoma Basing Transcriptome-Wide Profiling. Shi J, et al. World Neurosurg, 2022 Apr. PMID 35092815
  5. The human olfactory receptor gene family. Malnic B, et al. Proc Natl Acad Sci U S A, 2004 Feb 24. PMID 14983052, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Preliminary evidence that Merkel cells exert chemosensory functions in human epidermis.
    Title: Preliminary evidence that Merkel cells exert chemosensory functions in human epidermis.
  2. Identification of Key Biomarkers and Immune Infiltration in Sporadic Vestibular Schwannoma Basing Transcriptome-Wide Profiling.
    Title: Identification of Key Biomarkers and Immune Infiltration in Sporadic Vestibular Schwannoma Basing Transcriptome-Wide Profiling.
  3. Study shows that human hair follicles (HF) can engage in chemosensation and that the specific activation of OR2AT4 is required to sustain HF growth.
    Title: Olfactory receptor OR2AT4 regulates human hair growth.
  4. OR2AT4 is involved in human keratinocyte re-epithelialization during wound-healing processes
    Title: A synthetic sandalwood odorant induces wound-healing processes in human keratinocytes via the olfactory receptor OR2AT4.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables olfactory receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
olfactory receptor 2AT4
Names
olfactory receptor OR11-265 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005285.2 → NP_001005285.1  olfactory receptor 2AT4 isoform 1

    See identical proteins and their annotated locations for NP_001005285.1

    Status: VALIDATED

    Source sequence(s)
    AP001972, AP003175
    Consensus CDS
    CCDS31639.1
    UniProtKB/Swiss-Prot
    A6NND4, B9EGZ8
    UniProtKB/TrEMBL
    A0A126GWB1
    Related
    ENSP00000304846.3, ENST00000305159.3
    Conserved Domains (1) summary
    cd13954
    Location:45 → 299
    7tmA_OR; olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_001405852.1 → NP_001392781.1  olfactory receptor 2AT4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AP001972, AP003175
    UniProtKB/Swiss-Prot
    A6NND4, B9EGZ8
    UniProtKB/TrEMBL
    A0A126GWB1
    Related
    ENSP00000493318.1, ENST00000641504.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    75081753..75096890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    75011299..75026436 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A6NND4.1 GenPept UniProtKB/Swiss-Prot:A6NND4

Gene LinkOut

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