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OR2AT4 olfactory receptor family 2 subfamily AT member 4 [ Homo sapiens (human) ]

Gene ID: 341152, updated on 22-Sep-2022

Summary

Official Symbol
OR2AT4provided by HGNC
Official Full Name
olfactory receptor family 2 subfamily AT member 4provided by HGNC
Primary source
HGNC:HGNC:19620
See related
Ensembl:ENSG00000171561 AllianceGenome:HGNC:19620
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OR11-265
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See OR2AT4 in Genome Data Viewer
Location:
11q13.4
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (75088692..75096890, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (75018238..75026436, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (74799737..74807935, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily AT member 2 pseudogene Neighboring gene nucleophosmin 1 pseudogene 50 Neighboring gene CRISPRi-validated cis-regulatory element chr11.4261 Neighboring gene FA complementation group L pseudogene Neighboring gene olfactory receptor family 2 subfamily AT member 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables olfactory receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
olfactory receptor 2AT4
Names
olfactory receptor OR11-265 pseudogene

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005285.2NP_001005285.1  olfactory receptor 2AT4 isoform 1

    See identical proteins and their annotated locations for NP_001005285.1

    Status: VALIDATED

    Source sequence(s)
    AP001972, AP003175
    Consensus CDS
    CCDS31639.1
    UniProtKB/Swiss-Prot
    A6NND4, B9EGZ8
    UniProtKB/TrEMBL
    A0A126GWB1
    Related
    ENSP00000493318.1, ENST00000641504.1
    Conserved Domains (1) summary
    cd13954
    Location:45299
    7tmA_OR; olfactory receptors, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_001405852.1NP_001392781.1  olfactory receptor 2AT4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AP001972, AP003175
    UniProtKB/Swiss-Prot
    B9EGZ8
    UniProtKB/TrEMBL
    A0A126GWB1

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    75088692..75096890 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    75018238..75026436 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)