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WDR97 WD repeat domain 97 [ Homo sapiens (human) ]

Gene ID: 340390, updated on 23-Nov-2021

Summary

Official Symbol
WDR97provided by HGNC
Official Full Name
WD repeat domain 97provided by HGNC
Primary source
HGNC:HGNC:26959
See related
Ensembl:ENSG00000179698
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KIAA1875
Summary
The function and protein-coding potential of this gene is unknown. The exon combination is based on AB058778.1 for which two possible open reading frames can be predicted (with start codons at nucleotide 26 or 2614). The position of the first ORF stop codon is consistent with a prediction of nonsense-mediated decay. Given the observation of the first ORF and its length, a predicted translation of the second ORF is inconsistent with the translation leaky scanning theory. Therefore, this gene is represented as a non-protein-coding transcript. [provided by RefSeq, Oct 2008]
Expression
Biased expression in testis (RPKM 5.3), brain (RPKM 0.6) and 9 other tissues See more
Orthologs
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Genomic context

See WDR97 in Genome Data Viewer
Location:
8q24.3
Exon count:
24
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (144107739..144118328)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (145162642..145173231)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene SHANK associated RH domain interactor Neighboring gene Sharpr-MPRA regulatory region 2030 Neighboring gene MAF1 homolog, negative regulator of RNA polymerase III Neighboring gene HGH1 homolog Neighboring gene testis specific serine kinase 5, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
WD repeat-containing protein 97

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001316309.2NP_001303238.1  WD repeat-containing protein 97

    Status: VALIDATED

    Source sequence(s)
    AC104592
    Consensus CDS
    CCDS83334.1
    UniProtKB/Swiss-Prot
    A6NE52
    Related
    ENSP00000320648.8, ENST00000323662.9
    Conserved Domains (3) summary
    COG2319
    Location:206363
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:252288
    7WD40; WD40 repeat [structural motif]
    cl02567
    Location:200370
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    144107739..144118328
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447145.1XP_024302913.1  WD repeat-containing protein 97 isoform X1

    Conserved Domains (3) summary
    COG2319
    Location:226444
    WD40; WD40 repeat [General function prediction only]
    sd00039
    Location:3056
    7WD40; WD40 repeat [structural motif]
    cl25539
    Location:263
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_032529.1: Suppressed sequence

    Description
    NM_032529.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.
  2. NR_024207.1: Suppressed sequence

    Description
    NR_024207.1: This RefSeq was removed because it is now thought that this gene does encode a protein.
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