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ANKRD34B ankyrin repeat domain 34B [ Homo sapiens (human) ]

Gene ID: 340120, updated on 2-Nov-2024

Summary

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Official Symbol
ANKRD34Bprovided by HGNC
Official Full Name
ankyrin repeat domain 34Bprovided by HGNC
Primary source
HGNC:HGNC:33736
See related
Ensembl:ENSG00000189127 MIM:618581; AllianceGenome:HGNC:33736
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DP58
Summary
Predicted to be located in cytoplasm and nucleus. Predicted to be active in pi-body. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

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See ANKRD34B in Genome Data Viewer
Location:
5q14.1
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (80556755..80570280, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (81040746..81054295, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (79852574..79866099, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 151 member B Neighboring gene RPS27A pseudogene 9 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:79802930-79803430 Neighboring gene ribosomal protein L7 pseudogene 24 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr5:79808370-79809569 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:79850523-79851153 Neighboring gene long intergenic non-protein coding RNA 1337 Neighboring gene DBI pseudogene 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Age-Related DNA Methylation in Normal Kidney Tissue Identifies Epigenetic Cancer Risk Susceptibility Loci in the ANKRD34B and ZIC1 Genes. Serth J, et al. Int J Mol Sci, 2022 May 10. PMID 35628134, Free PMC Article
  2. A novel phosphoprotein is induced during bone marrow commitment to dendritic cells. Al-Shaibi N, et al. Biochem Biophys Res Commun, 2004 Aug 13. PMID 15358210
  3. WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation. Jeong WJ, et al. Nat Commun, 2019 Jan 17. PMID 30655611, Free PMC Article
  4. SUMOylation of DDX39A Alters Binding and Export of Antiviral Transcripts to Control Innate Immunity. Shi P, et al. J Immunol, 2020 Jul 1. PMID 32393512
  5. OpenCell: Endogenous tagging for the cartography of human cellular organization. Cho NH, et al. Science, 2022 Mar 11. PMID 35271311, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Age-Related DNA Methylation in Normal Kidney Tissue Identifies Epigenetic Cancer Risk Susceptibility Loci in the ANKRD34B and ZIC1 Genes.
    Title: Age-Related DNA Methylation in Normal Kidney Tissue Identifies Epigenetic Cancer Risk Susceptibility Loci in the ANKRD34B and ZIC1 Genes.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
is_active_in pi-body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
ankyrin repeat domain-containing protein 34B
Names
cytosolic phosphoprotein DP58
dendritic phosphoprotein 58 kDa

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001004441.3 → NP_001004441.2  ankyrin repeat domain-containing protein 34B

    See identical proteins and their annotated locations for NP_001004441.2

    Status: VALIDATED

    Source sequence(s)
    AC008434, BC137441, CR749535
    Consensus CDS
    CCDS34194.1
    UniProtKB/Swiss-Prot
    A5PLL1, B2RPH1, Q68D79
    Related
    ENSP00000339802.3, ENST00000338682.8
    Conserved Domains (3) summary
    cd00204
    Location:31 → 138
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam13857
    Location:70 → 125
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:42 → 81
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    80556755..80570280 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417142.1 → XP_047273098.1  ankyrin repeat domain-containing protein 34B isoform X1

    UniProtKB/Swiss-Prot
    A5PLL1, B2RPH1, Q68D79

  2. XM_006714599.4 → XP_006714662.1  ankyrin repeat domain-containing protein 34B isoform X1

    See identical proteins and their annotated locations for XP_006714662.1

    UniProtKB/Swiss-Prot
    A5PLL1, B2RPH1, Q68D79
    Conserved Domains (3) summary
    cd00204
    Location:31 → 138
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam13857
    Location:70 → 125
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:42 → 81
    ANK; ANK repeat [structural motif]

  3. XM_011543366.3 → XP_011541668.1  ankyrin repeat domain-containing protein 34B isoform X1

    See identical proteins and their annotated locations for XP_011541668.1

    UniProtKB/Swiss-Prot
    A5PLL1, B2RPH1, Q68D79
    Conserved Domains (3) summary
    cd00204
    Location:31 → 138
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam13857
    Location:70 → 125
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:42 → 81
    ANK; ANK repeat [structural motif]

  4. XM_047417141.1 → XP_047273097.1  ankyrin repeat domain-containing protein 34B isoform X1

    UniProtKB/Swiss-Prot
    A5PLL1, B2RPH1, Q68D79

  5. XM_047417143.1 → XP_047273099.1  ankyrin repeat domain-containing protein 34B isoform X1

    UniProtKB/Swiss-Prot
    A5PLL1, B2RPH1, Q68D79

  6. XM_011543369.2 → XP_011541671.1  ankyrin repeat domain-containing protein 34B isoform X1

    See identical proteins and their annotated locations for XP_011541671.1

    UniProtKB/Swiss-Prot
    A5PLL1, B2RPH1, Q68D79
    Conserved Domains (3) summary
    cd00204
    Location:31 → 138
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam13857
    Location:70 → 125
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:42 → 81
    ANK; ANK repeat [structural motif]

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    81040746..81054295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054352505.1 → XP_054208480.1  ankyrin repeat domain-containing protein 34B isoform X1

  2. XM_054352504.1 → XP_054208479.1  ankyrin repeat domain-containing protein 34B isoform X1

  3. XM_054352502.1 → XP_054208477.1  ankyrin repeat domain-containing protein 34B isoform X1

  4. XM_054352503.1 → XP_054208478.1  ankyrin repeat domain-containing protein 34B isoform X1

  5. XM_054352506.1 → XP_054208481.1  ankyrin repeat domain-containing protein 34B isoform X1

  6. XM_054352507.1 → XP_054208482.1  ankyrin repeat domain-containing protein 34B isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A5PLL1.3 GenPept UniProtKB/Swiss-Prot:A5PLL1

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