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GADL1 glutamate decarboxylase like 1 [ Homo sapiens (human) ]

Gene ID: 339896, updated on 13-May-2022

Summary

Official Symbol
GADL1provided by HGNC
Official Full Name
glutamate decarboxylase like 1provided by HGNC
Primary source
HGNC:HGNC:27949
See related
Ensembl:ENSG00000144644 MIM:615601; AllianceGenome:HGNC:27949
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADC; CSADC; HuADC; HuCSADC
Summary
Predicted to enable aspartate 1-decarboxylase activity; pyridoxal phosphate binding activity; and sulfinoalanine decarboxylase activity. Predicted to be involved in carboxylic acid metabolic process. Predicted to be located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See GADL1 in Genome Data Viewer
Location:
3p24.1-p23
Exon count:
17
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (30726197..30894661, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (30728666..30897141, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (30767689..30936153, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene translation initiation factor IF-2-like Neighboring gene uncharacterized LOC105377016 Neighboring gene transforming growth factor beta receptor 2 Neighboring gene formin binding protein 1 pseudogene 2 Neighboring gene microRNA 466 Neighboring gene calponin 2 pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
An atlas of genetic influences on human blood metabolites.
EBI GWAS Catalog
Genetic variants associated with disordered eating.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC138191

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables aspartate 1-decarboxylase activity IEA
Inferred from Electronic Annotation
more info
 
enables carboxy-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 
enables sulfinoalanine decarboxylase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
acidic amino acid decarboxylase GADL1
Names
aspartate 1-decarboxylase
cysteine sulfinic acid decarboxylase
glutamate decarboxylase-like protein 1
NP_997242.2
XP_016861786.1
XP_047304027.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_207359.3NP_997242.2  acidic amino acid decarboxylase GADL1

    See identical proteins and their annotated locations for NP_997242.2

    Status: VALIDATED

    Source sequence(s)
    AC096921, AC138391, AK128643, AL832766, BC093701
    Consensus CDS
    CCDS2649.2
    UniProtKB/Swiss-Prot
    Q6ZQY3
    Related
    ENSP00000282538.5, ENST00000282538.10
    Conserved Domains (1) summary
    cl18945
    Location:77445
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    30726197..30894661 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006297.2XP_016861786.1  acidic amino acid decarboxylase GADL1 isoform X1

  2. XM_047448071.1XP_047304027.1  acidic amino acid decarboxylase GADL1 isoform X2

    Related
    ENSP00000427059.1, ENST00000454381.3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    30728666..30897141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)