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MRPL58 mitochondrial ribosomal protein L58 [ Homo sapiens (human) ]

Gene ID: 3396, updated on 21-Apr-2019

Summary

Official Symbol
MRPL58provided by HGNC
Official Full Name
mitochondrial ribosomal protein L58provided by HGNC
Primary source
HGNC:HGNC:5359
See related
Ensembl:ENSG00000167862 MIM:603000
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DS1; DS-1; ICT1; MRP-L58
Summary
The protein encoded by this gene is a peptidyl-tRNA hydrolase and a vital component of the large mitochondrial ribosome. The encoded protein serves as a ribosome release factor for this ribosome, which translates mitochondrial genes. This protein may be responsible for degrading prematurely-terminated polypeptides and for reusing stalled ribosomes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
Expression
Ubiquitous expression in heart (RPKM 10.6), kidney (RPKM 10.3) and 25 other tissues See more
Orthologs

Genomic context

See MRPL58 in Genome Data Viewer
Location:
17q25.1
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (75012664..75021261)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (73008760..73017356)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene HID1 domain containing Neighboring gene HID1 antisense RNA 1 Neighboring gene cerebellar degeneration related protein 2 like Neighboring gene RNA, U6 small nuclear 362, pseudogene Neighboring gene transfer RNA-Arg (CCT) 1-1 Neighboring gene potassium channel tetramerization domain containing 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Mitochondrial translation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation, organism-specific biosystemOf the roughly 1000 human mitochondrial proteins only 13 proteins, all of them hydrophobic inner membrane proteins that are components of the oxidative phosphorylation apparatus, are encoded in the m...
  • Mitochondrial translation elongation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation elongation, organism-specific biosystemTranslation elongation proceeds by cycles of aminoacyl-tRNAs binding, peptide bond formation, and displacement of deacylated tRNAs (reviewed in Christian and Spremulli 2012). In each cycle an aminoac...
  • Mitochondrial translation initiation, organism-specific biosystem (from REACTOME)
    Mitochondrial translation initiation, organism-specific biosystemTranslation initiates with the mitochondrial mRNA binding the 28S subunit:MTIF3 (28S subunit:IF-3Mt, 28S subunit:IF3mt) complex together with MTIF2:GTP (IF-2Mt:GTP, IF2mt:GTP) (reviewed in Christian ...
  • Mitochondrial translation termination, organism-specific biosystem (from REACTOME)
    Mitochondrial translation termination, organism-specific biosystemTranslation is terminated when MTRF1L:GTP (MTRF1a:GTP) recognizes a UAA or UAG termination codon in the mRNA at the A site of the ribosome (Soleimanpour-Lichaei et al. 2007, reviewed in Richter et al...
  • Organelle biogenesis and maintenance, organism-specific biosystem (from REACTOME)
    Organelle biogenesis and maintenance, organism-specific biosystemThis module describes the biogenesis of organelles. Organelles are subcellular structures of distinctive morphology and function. The organelles of human cells include: mitochondria, endoplasmic reti...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
aminoacyl-tRNA hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
translation release factor activity, codon nonspecific IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
mitochondrial translational elongation TAS
Traceable Author Statement
more info
 
mitochondrial translational termination IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial translational termination TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial large ribosomal subunit IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial matrix TAS
Traceable Author Statement
more info
 
mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
peptidyl-tRNA hydrolase ICT1, mitochondrial
Names
39S ribosomal protein L58, mitochondrial
digestion substraction 1
immature colon carcinoma transcript 1 protein
mitochondrial large ribosomal subunit protein ICT1
mitochondrial large ribosomal subunit protein mL62
NP_001290194.1
NP_001536.1
XP_016880063.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303265.1NP_001290194.1  peptidyl-tRNA hydrolase ICT1, mitochondrial isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice junction in the 3' coding region compared to variant 1, that causes a frameshift. The resulting isoform (2) has a longer and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC015335, BI870683, DB456649
    UniProtKB/Swiss-Prot
    Q14197
    Conserved Domains (1) summary
    cl23917
    Location:72170
    RF-1; RF-1 domain
  2. NM_001545.3NP_001536.1  peptidyl-tRNA hydrolase ICT1, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_001536.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the predominant isoform (1).
    Source sequence(s)
    BC015335, DB456649
    Consensus CDS
    CCDS11711.1
    UniProtKB/Swiss-Prot
    Q14197
    Related
    ENSP00000301585.5, ENST00000301585.10
    Conserved Domains (1) summary
    cl27687
    Location:72202
    RF-1; RF-1 domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    75012664..75021261
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024574.1XP_016880063.1  peptidyl-tRNA hydrolase ICT1, mitochondrial isoform X1

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