LINC01139 long intergenic non-protein coding RNA 1139 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LINC01139provided by HGNC
Official Full Name: long intergenic non-protein coding RNA 1139provided by HGNC
Primary source: HGNC:HGNC:27924
See related: Ensembl:ENSG00000215808 AllianceGenome:HGNC:27924
Gene type: ncRNA
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LINKA; LINK-A
Expression: Biased expression in endometrium (RPKM 6.7), kidney (RPKM 6.3) and 7 other tissues See more
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Genomic context

Location:: 1q43

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (238480384..238486017, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (237891834..237897469, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (238643684..238649317, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The role of long intergenic non-coding RNA for kinase activation (LINK-A) as an oncogene in non-small cell lung carcinoma.
Title: The role of long intergenic non-coding RNA for kinase activation (LINK-A) as an oncogene in non-small cell lung carcinoma.
High expression of long non-coding RNA Linc-A associates with poor survival in patients with colorectal cancer.
Title: High expression of long non-coding RNA Linc-A associates with poor survival in patients with colorectal cancer.
The Biological Role of the Long Non-coding RNA LINK-A in Ovarian Carcinoma.
Title: The Biological Role of the Long Non-coding RNA LINK-A in Ovarian Carcinoma.
Long noncoding RNA LINC01139 promotes the progression of hepatocellular carcinoma by upregulating MYBL2 via competitively binding to miR-30 family.
Title: Long noncoding RNA LINC01139 promotes the progression of hepatocellular carcinoma by upregulating MYBL2 via competitively binding to miR-30 family.
LINK-A lncRNA may promote migration and invasion of ovarian carcinoma cells by activating TGF-beta pathway.
Title: LINK-A lncRNA promotes migration and invasion of ovarian carcinoma cells by activating TGF-β pathway.
LDH-A was involved in the LINK-A-mediated proliferation.
Title: Long non-coding RNA LINK-A promotes glioma cell growth and invasion via lactate dehydrogenase A.
LINK-A-dependent AKT hyperactivation leads to tumorigenesis and resistance to AKT inhibitors.
Title: The LINK-A lncRNA interacts with PtdIns(3,4,5)P(3) to hyperactivate AKT and confer resistance to AKT inhibitors.
Both LINK-A expression and LINK-A-dependent signalling pathway activation correlate with triple-negative breast cancer, promoting breast cancer glycolysis reprogramming and tumorigenesis.
Title: The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Other Names

TCONS_00000027
long intergenic non-coding RNA for kinase activation

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.