Format

Send to:

Choose Destination

ENPP7 ectonucleotide pyrophosphatase/phosphodiesterase 7 [ Homo sapiens (human) ]

Gene ID: 339221, updated on 10-Jul-2021

Summary

Official Symbol
ENPP7provided by HGNC
Official Full Name
ectonucleotide pyrophosphatase/phosphodiesterase 7provided by HGNC
Primary source
HGNC:HGNC:23764
See related
Ensembl:ENSG00000182156 MIM:616997
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NPP7; NPP-7; E-NPP 7; ALK-SMase
Summary
The protein encoded by this gene is an intestinal alkaline sphingomyelin phosphodiesterase that converts sphingomyelin to ceramide and phosphocholine. The encoded protein is anchored in the cell membrane, and it may function to protect the intestinal mucosa from inflammation and tumorigenesis. This protein is glycosylated and also exhibits lysophosphatidylcholine hydrolase activity. [provided by RefSeq, Oct 2016]
Expression
Biased expression in small intestine (RPKM 36.1), duodenum (RPKM 15.1) and 1 other tissue See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See ENPP7 in Genome Data Viewer
Location:
17q25.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (79730919..79742926)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (77704705..77716018)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2078 Neighboring gene Sharpr-MPRA regulatory region 9091 Neighboring gene chromobox 2 Neighboring gene chromobox 8

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC50179

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables phosphoric diester hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sphingomyelin phosphodiesterase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables sphingomyelin phosphodiesterase activity TAS
Traceable Author Statement
more info
 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in fatty acid homeostasis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in glycosphingolipid metabolic process TAS
Traceable Author Statement
more info
 
involved_in lipid digestion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of DNA replication IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ceramide biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of intestinal cholesterol absorption ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of sphingomyelin catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of intestinal lipid absorption ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in sphingomyelin catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sphingomyelin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in microvillus IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
ectonucleotide pyrophosphatase/phosphodiesterase family member 7
Names
alkaline sphingomyelin phosphodiesterase
alkaline sphingomyelinase
intestinal alkaline sphingomyelinase
NP_848638.3
XP_011523039.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051988.1 RefSeqGene

    Range
    5025..16301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_178543.5NP_848638.3  ectonucleotide pyrophosphatase/phosphodiesterase family member 7 precursor

    See identical proteins and their annotated locations for NP_848638.3

    Status: REVIEWED

    Source sequence(s)
    AC233701, BC041453, DB187443
    Consensus CDS
    CCDS11763.1
    UniProtKB/Swiss-Prot
    Q6UWV6
    Related
    ENSP00000332656.5, ENST00000328313.10
    Conserved Domains (1) summary
    cd16018
    Location:31396
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    79730919..79742926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011524737.1XP_011523039.1  ectonucleotide pyrophosphatase/phosphodiesterase family member 7 isoform X1

    Conserved Domains (2) summary
    pfam01663
    Location:106413
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:104325
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

RNA

  1. XR_001752505.1 RNA Sequence

Support Center