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RNASE10 ribonuclease A family member 10 (inactive) [ Homo sapiens (human) ]

Gene ID: 338879, updated on 26-Oct-2022

Summary

Official Symbol
RNASE10provided by HGNC
Official Full Name
ribonuclease A family member 10 (inactive)provided by HGNC
Primary source
HGNC:HGNC:19275
See related
Ensembl:ENSG00000182545 AllianceGenome:HGNC:19275
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAH1; RNASE9
Summary
Predicted to enable nucleic acid binding activity. Predicted to be involved in several processes, including heterotypic cell-cell adhesion; positive regulation of flagellated sperm motility; and regulation of fertilization. Predicted to act upstream of or within epithelial cell morphogenesis; seminiferous tubule development; and single fertilization. Predicted to be located in extracellular region. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See RNASE10 in Genome Data Viewer
Location:
14q11.2
Exon count:
3
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (20504233..20513884)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (14701150..14711005)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (20972392..20982043)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene apurinic/apyrimidinic endodeoxyribonuclease 1 Neighboring gene phosphatidylinositol-4,5-bisphosphate 4-phosphatase 1 Neighboring gene purine nucleoside phosphorylase Neighboring gene pentatricopeptide repeat domain 2 pseudogene 1 Neighboring gene SET pseudogene 1

Genomic regions, transcripts, and products

Phenotypes

EBI GWAS Catalog

Description
Genome-wide SNP associations with rubella-specific cytokine responses in measles-mumps-rubella vaccine recipients.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
NOT enables ribonuclease activity IKR
Inferred from Key Residues
more info
PubMed 
Process Evidence Code Pubs
involved_in defense response to Gram-positive bacterium IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in heterotypic cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of cell-cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of flagellated sperm motility ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of fertilization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in single fertilization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
inactive ribonuclease-like protein 10
Names
ribonuclease A H1
ribonuclease, RNase A family, 10 (non-active)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012975.3NP_001012993.1  inactive ribonuclease-like protein 10 precursor

    See identical proteins and their annotated locations for NP_001012993.1

    Status: VALIDATED

    Source sequence(s)
    AL355075
    Consensus CDS
    CCDS32035.1
    UniProtKB/Swiss-Prot
    B4DKY4, Q5GAN6
    UniProtKB/TrEMBL
    W0UTC4
    Related
    ENSP00000333358.5, ENST00000328444.6
    Conserved Domains (1) summary
    cd00163
    Location:108213
    RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...
  2. NM_001386206.2NP_001373135.2  inactive ribonuclease-like protein 10 precursor

    Status: VALIDATED

    Source sequence(s)
    AL355075
    Consensus CDS
    CCDS32035.1
    UniProtKB/Swiss-Prot
    B4DKY4
    UniProtKB/TrEMBL
    W0UTC4
    Related
    ENSP00000392996.2, ENST00000430083.2
    Conserved Domains (1) summary
    cd00163
    Location:108213
    RNase_A; RNase A family, or Pancreatic RNases family; includes vertebrate RNase homologs to the bovine pancreatic ribonuclease A (RNase A). Many of these enzymes have special biological activities; for example, some stimulate the development of vascular ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    20504233..20513884
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791796.1 Reference GRCh38.p14 PATCHES

    Range
    706914..716565
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    14701150..14711005
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)