Gmd GDP-mannose 4,6-dehydratase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Gmdprovided by FlyBase
Official Full Name: GDP-mannose 4,6-dehydrataseprovided by FlyBase
Primary source: FLYBASE:FBgn0031661
Locus tag: Dmel_CG8890
See related: AllianceGenome:FB:FBgn0031661
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: Brazil nut; CG8890; Dm-gmd; Dmel\CG8890; DmGMD; gmd; GMD; l(2)SH1606; l(2)SH2 1606
Summary: Enables GDP-mannose 4,6-dehydratase activity. Involved in several processes, including 'de novo' GDP-L-fucose biosynthetic process; oogenesis; and positive regulation of Notch signaling pathway. Predicted to be active in cytoplasm. Is expressed in several structures, including anterior endoderm; anterior endoderm anlage; embryonic brain; extended germ band embryo; and wing disc. Human ortholog(s) of this gene implicated in open-angle glaucoma. Orthologous to human GMDS (GDP-mannose 4,6-dehydratase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (4975300..4977023, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (4975300..4977023, complement)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

cloning, purification and charactrization of GMD
Title: Reconstitution in vitro of the GDP-fucose biosynthetic pathways of Caenorhabditis elegans and Drosophila melanogaster.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables GDP-mannose 4,6-dehydratase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GDP-mannose 4,6-dehydratase activity	IDA Inferred from Direct Assay more info	PubMed
enables GDP-mannose 4,6-dehydratase activity	IEA Inferred from Electronic Annotation more info
enables GDP-mannose 4,6-dehydratase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in 'de novo' GDP-L-fucose biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in 'de novo' GDP-L-fucose biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in 'de novo' GDP-L-fucose biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in GDP-mannose metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in GDP-mannose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cell fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in oogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info

Names: CG8890-PA; GDP-D-mannose 4,6-dehydratase; GDP-mannose 4,6 dehydratase; GDP-mannose 4,6-dehydrase; GDP-mannose dehydratase; Gmd-PA

NP_608888.2

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The following sections contain reference sequences that belong to a specific genome build. Explain