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HTR7 5-hydroxytryptamine receptor 7 [ Homo sapiens (human) ]

Gene ID: 3363, updated on 21-Jun-2020

Summary

Official Symbol
HTR7provided by HGNC
Official Full Name
5-hydroxytryptamine receptor 7provided by HGNC
Primary source
HGNC:HGNC:5302
See related
Ensembl:ENSG00000148680 MIM:182137
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
5-HT7
Summary
The neurotransmitter, serotonin, is thought to play a role in various cognitive and behavioral functions. The serotonin receptor encoded by this gene belongs to the superfamily of G protein-coupled receptors and the gene is a candidate locus for involvement in autistic disorder and other neuropsychiatric disorders. Three splice variants have been identified which encode proteins that differ in the length of their carboxy terminal ends. [provided by RefSeq, Jul 2008]
Expression
Biased expression in testis (RPKM 6.1), urinary bladder (RPKM 2.0) and 8 other tissues See more
Orthologs

Genomic context

See HTR7 in Genome Data Viewer
Location:
10q23.31
Exon count:
5
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (90738693..90858039, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (92500575..92617671, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378426 Neighboring gene long intergenic non-protein coding RNA 2653 Neighboring gene Sharpr-MPRA regulatory region 7939 Neighboring gene ribonuclease P/MRP subunit p30 Neighboring gene ankyrin repeat domain 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Common genetic variants and gene expression associated with white matter microstructure in the human brain.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G protein-coupled serotonin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
blood circulation TAS
Traceable Author Statement
more info
PubMed 
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
circadian rhythm IEA
Inferred from Electronic Annotation
more info
 
smooth muscle contraction IEA
Inferred from Electronic Annotation
more info
 
vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
5-hydroxytryptamine receptor 7
Names
5-HT-7
5-HT-X
5-hydroxytryptamine (serotonin) receptor 7 (adenylate cyclase-coupled)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029218.1 RefSeqGene

    Range
    4876..122092
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000872.5NP_000863.1  5-hydroxytryptamine receptor 7 isoform a

    See identical proteins and their annotated locations for NP_000863.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) results from the alternative usage of the first of two tandemly arranged splice donor sites at the 5' end of intron 2, which causes the protein to have a 13 amino acid longer carboxy tail relative to isoform b.
    Source sequence(s)
    AL360011, BC047526, BG108256
    Consensus CDS
    CCDS7409.1
    UniProtKB/Swiss-Prot
    P34969
    Related
    ENSP00000277874.6, ENST00000277874.10
    Conserved Domains (1) summary
    cd15329
    Location:97395
    7tmA_5-HT7; serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors
  2. NM_019859.4NP_062873.1  5-hydroxytryptamine receptor 7 isoform d

    See identical proteins and their annotated locations for NP_062873.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) results from the inclusion of a 98 base pair exon cassette (exon D) at the exon II/exon III boundary, as compared to splice variant a. The inclusion of exon D results in a protein with a carboxy terminal end 34 amino acids longer than the splice variant a protein.
    Source sequence(s)
    AL360011, BC047526, BG108256, U68488
    Consensus CDS
    CCDS7408.1
    UniProtKB/Swiss-Prot
    P34969
    Related
    ENSP00000337949.3, ENST00000336152.8
    Conserved Domains (2) summary
    pfam00001
    Location:98384
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:98215
    7tm_4; Olfactory receptor
  3. NM_019860.4NP_062874.1  5-hydroxytryptamine receptor 7 isoform b

    See identical proteins and their annotated locations for NP_062874.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) results from the alternative usage of the second of the two tandemly arranged splice donor sites at the 5' end of intron 2, which causes an in-frame stop codon and shortens the protein's carboxy tail by 13 amino acids relative to isoform a.
    Source sequence(s)
    AL360011, BC047526, BG108256, U68487
    Consensus CDS
    CCDS7410.1
    UniProtKB/Swiss-Prot
    P34969
    Related
    ENSP00000360784.2, ENST00000371719.2
    Conserved Domains (1) summary
    cd15329
    Location:97395
    7tmA_5-HT7; serotonin receptor subtype 7, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    90738693..90858039 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447973.1XP_024303741.1  5-hydroxytryptamine receptor 7 isoform X1

    Conserved Domains (2) summary
    cd15329
    Location:319
    7tmA_5-HT7; TM helix 4 [structural motif]
    cl28897
    Location:1197
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
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