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HTR3A 5-hydroxytryptamine receptor 3A [ Homo sapiens (human) ]

Gene ID: 3359, updated on 13-Oct-2018

Summary

Official Symbol
HTR3Aprovided by HGNC
Official Full Name
5-hydroxytryptamine receptor 3Aprovided by HGNC
Primary source
HGNC:HGNC:5297
See related
Ensembl:ENSG00000166736 MIM:182139; Vega:OTTHUMG00000160494
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HTR3; 5HT3R; 5-HT-3; 5-HT3A; 5-HT3R
Summary
The product of this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit A of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor causes fast, depolarizing responses in neurons after activation. It appears that the heteromeric combination of A and B subunits is necessary to provide the full functional features of this receptor, since either subunit alone results in receptors with very low conductance and response amplitude. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lymph node (RPKM 3.0), appendix (RPKM 1.1) and 6 other tissues See more
Orthologs

Genomic context

See HTR3A in Genome Data Viewer
Location:
11q23.2
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 11 NC_000011.10 (113975075..113990313)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (113845797..113861035)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene ubiquitin specific peptidase 28 Neighboring gene RNA, U6 small nuclear 1107, pseudogene Neighboring gene 5-hydroxytryptamine receptor 3B Neighboring gene zinc finger and BTB domain containing 16 Neighboring gene uncharacterized LOC101928875 Neighboring gene nicotinamide N-methyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Ion channel transport, organism-specific biosystem (from REACTOME)
    Ion channel transport, organism-specific biosystemIon channels mediate the flow of ions across the plasma membrane of cells. They are integral membrane proteins, typically a multimer of proteins, which, when arranged in the membrane, create a pore f...
  • Ligand-gated ion channel transport, organism-specific biosystem (from REACTOME)
    Ligand-gated ion channel transport, organism-specific biosystemLigand-gated ion channels (LGICs) are a group of transmembrane ion channels that are opened or closed in response to the binding of a chemical messenger (Purves, 2001).
  • Serotonergic synapse, organism-specific biosystem (from KEGG)
    Serotonergic synapse, organism-specific biosystemSerotonin (5-Hydroxytryptamine, 5-HT) is a monoamine neurotransmitter that plays important roles in physiological functions such as learning and memory, emotion, sleep, pain, motor function and endoc...
  • Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
  • Taste transduction, organism-specific biosystem (from KEGG)
    Taste transduction, organism-specific biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...
  • Taste transduction, conserved biosystem (from KEGG)
    Taste transduction, conserved biosystemFive basic tastes are recognized by humans and most other animals - bitter, sweet, sour, salty and umami. In vertebrates, taste stimuli are detected by taste receptor cells (TRCs). At least three dis...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to extracellular ligand-gated ion channel activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serotonin binding IDA
Inferred from Direct Assay
more info
PubMed 
serotonin-gated cation-selective channel activity IDA
Inferred from Direct Assay
more info
PubMed 
transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nervous system process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of ion transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
 
regulation of membrane potential IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to cocaine IEA
Inferred from Electronic Annotation
more info
 
response to ethanol IEA
Inferred from Electronic Annotation
more info
 
serotonin receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
axon IEA
Inferred from Electronic Annotation
more info
 
cell junction IEA
Inferred from Electronic Annotation
more info
 
cleavage furrow IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of presynaptic membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuronal cell body IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
serotonin-activated cation-selective channel complex IDA
Inferred from Direct Assay
more info
PubMed 
synapse IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
5-hydroxytryptamine receptor 3A
Names
5-HT3-A
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic
5-hydroxytryptamine receptor 3
5HT3 serotonin receptor
serotonin receptor 3A
serotonin-gated ion channel receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013058.1 RefSeqGene

    Range
    5034..20239
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000869.6NP_000860.3  5-hydroxytryptamine receptor 3A isoform b precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (b), that is missing an internal segment compared to isoform a.
    Source sequence(s)
    AK304630, AP000908, BC002354
    Consensus CDS
    CCDS8365.2
    Related
    ENSP00000364648.2, ENST00000375498.6
    Conserved Domains (1) summary
    TIGR00860
    Location:23472
    LIC; Cation transporter family protein
  2. NM_001161772.2NP_001155244.1  5-hydroxytryptamine receptor 3A isoform c

    See identical proteins and their annotated locations for NP_001155244.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an alternate 5' exon and lacks an in-frame segment of the coding region, compared to variant 1. It encodes a shorter isoform (c), that has a different N-terminus and is missing an internal segment compared to isoform a.
    Source sequence(s)
    AK299973, AP000908, BC002354
    Consensus CDS
    CCDS53710.1
    UniProtKB/Swiss-Prot
    P46098
    Related
    ENSP00000299961.4, OTTHUMP00000218319, ENST00000299961.5, OTTHUMT00000360824
    Conserved Domains (3) summary
    TIGR00860
    Location:4457
    LIC; Cation transporter family protein
    pfam02931
    Location:21227
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:234453
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region
  3. NM_213621.4NP_998786.3  5-hydroxytryptamine receptor 3A isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as h5-HT3RL, represents the longest transcript, and encodes the longest isoform (a).
    Source sequence(s)
    AJ003078, AK304630, AP000908, CD014118
    Consensus CDS
    CCDS8366.2
    Related
    ENSP00000347754.2, ENST00000355556.6
    Conserved Domains (1) summary
    TIGR00860
    Location:23504
    LIC; Cation transporter family protein

RNA

  1. NR_046363.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate segment and an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AJ003080, AK304630, AP000908, BC002354

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p12 Primary Assembly

    Range
    113975075..113990313
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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