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hspa4a heat shock protein 4a [ Danio rerio (zebrafish) ]

Gene ID: 335865, updated on 12-Sep-2024

Summary

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Official Symbol
hspa4aprovided by ZNC
Official Full Name
heat shock protein 4aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-2832
See related
Ensembl:ENSDARG00000004754 AllianceGenome:ZFIN:ZDB-GENE-040426-2832
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
hspa4l; zgc:55506; wu:fc41d05; wu:fi59h02; wu:fj35c08
Summary
Predicted to enable ATP binding activity. Predicted to be active in cytosol and nucleus. Is expressed in several structures, including gut; head; liver; pectoral fin bud; and somite. Human ortholog(s) of this gene implicated in Chagas disease. Orthologous to human HSPA4 (heat shock protein family A (Hsp70) member 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 21
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (43137497..43171249, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (43142321..43176073, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene prolyl 4-hydroxylase subunit alpha-2 Neighboring gene procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), alpha polypeptide 2 Neighboring gene zinc finger, CCHC domain containing 10 Neighboring gene AF4/FMR2 family, member 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Zebrafish heat shock protein a4 genes in the intestinal epithelium are up-regulated during inflammation. Crawford KC, et al. Genesis, 2011 Dec. PMID 21557452
  2. Genome-Wide Identification of Hsp70 Genes in the Large Yellow Croaker (Larimichthys crocea) and Their Regulated Expression Under Cold and Heat Stress. Xu K, et al. Genes (Basel), 2018 Nov 29. PMID 30501106, Free PMC Article
  3. An integrated transcriptomic and proteomic approach characterizing estrogenic and metabolic effects of 17 alpha-ethinylestradiol in zebrafish (Danio rerio). De Wit M, et al. Gen Comp Endocrinol, 2010 Jun 1. PMID 20227414
  4. Zebrafish IRF1 regulates IFN antiviral response through binding to IFNϕ1 and IFNϕ3 promoters downstream of MyD88 signaling. Feng H, et al. J Immunol, 2015 Feb 1. PMID 25535281
  5. Mutation of kri1l causes definitive hematopoiesis failure via PERK-dependent excessive autophagy induction. Jia XE, et al. Cell Res, 2015 Aug. PMID 26138676, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables adenyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
heat shock 70 kDa protein 4a
Names
heat shock protein 4, like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_214716.1 → NP_999881.1  heat shock 70 kDa protein 4a

    See identical proteins and their annotated locations for NP_999881.1

    Status: PROVISIONAL

    Source sequence(s)
    BC051152
    UniProtKB/TrEMBL
    B2GS41, F6NRR7, Q7ZU46
    Related
    ENSDARP00000026086.7, ENSDART00000021037.10
    Conserved Domains (2) summary
    pfam00012
    Location:3 → 692
    HSP70; Hsp70 protein
    cl17037
    Location:2 → 384
    NBD_sugar-kinase_HSP70_actin; Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    43137497..43171249 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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