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CG40470 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 3355093, updated on 26-Apr-2024

Summary

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Official Symbol
CG40470provided by FlyBase
Primary source
FLYBASE:FBgn0058470
Locus tag
Dmel_CG40470
See related
AllianceGenome:FB:FBgn0058470
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG40470
Summary
Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm. Orthologous to human LVRN (laeverin) and TRHDE (thyrotropin releasing hormone degrading enzyme). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
80F9-80F9; 3-47 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (23839860..23986410, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (23832960..23979510, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43941 Neighboring gene long non-coding RNA:CR43942 Neighboring gene long non-coding RNA:CR40053 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Collapse of germline piRNAs in the absence of Argonaute3 reveals somatic piRNAs in flies. Li C, et al. Cell, 2009 May 1. PMID 19395009, Free PMC Article
  2. Genetic and Molecular Analysis of Essential Genes in Centromeric Heterochromatin of the Left Arm of Chromosome 3 in Drosophila melanogaster. Syrzycka M, et al. G3 (Bethesda), 2019 May 7. PMID 30948422, Free PMC Article
  3. Genetic screen in Drosophila melanogaster uncovers a novel set of genes required for embryonic epithelial repair. Campos I, et al. Genetics, 2010 Jan. PMID 19884309, Free PMC Article
  4. Genome-wide identification and comparative analysis of Cry toxin receptor families in 7 insect species with a focus on Spodoptera litura. Li Q, et al. Insect Sci, 2022 Jun. PMID 34405540
  5. The genetics of egg retention and fertilization success in Drosophila: One step closer to understanding the transition from facultative to obligate viviparity. Horváth B, et al. Evolution, 2018 Feb. PMID 29265369

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

mobile_element

  • Loc: c23841633-23840764 mobile_element_type = transposon:1360{}6358
  • Loc: c23904629-23903894 mobile_element_type = transposon:Q{}6555

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
NOT enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables peptidase activity IKR
Inferred from Key Residues
more info
  
NOT enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
NOT involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG40470-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    23839860..23986410 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001043170.2 → NP_001036635.1  uncharacterized protein Dmel_CG40470 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036635.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q500Y3, Q7PLV6
    Conserved Domains (2) summary
    pfam11838
    Location:584 → 906
    ERAP1_C; ERAP1-like C-terminal domain
    cl14813
    Location:60 → 503
    GluZincin; Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7PLV6 Q7PLV6

Gene LinkOut

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