U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

HTR1E 5-hydroxytryptamine receptor 1E [ Homo sapiens (human) ]

Gene ID: 3354, updated on 13-May-2022

Summary

Official Symbol
HTR1Eprovided by HGNC
Official Full Name
5-hydroxytryptamine receptor 1Eprovided by HGNC
Primary source
HGNC:HGNC:5291
See related
Ensembl:ENSG00000168830 MIM:182132; AllianceGenome:HGNC:5291
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
5-HT1E
Summary
Enables G protein-coupled serotonin receptor activity and serotonin binding activity. Involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in ovary (RPKM 1.3), endometrium (RPKM 0.7) and 4 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See HTR1E in Genome Data Viewer
Location:
6q14.3
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (86937528..87016679)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (88146245..88225391)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (87647246..87726397)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA, 7SL, cytoplasmic 643, pseudogene Neighboring gene Sharpr-MPRA regulatory region 4618 Neighboring gene ribosomal protein L7 pseudogene 29 Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase pseudogene 2 Neighboring gene small integral membrane protein 30-like Neighboring gene RN7SK pseudogene 209

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
enables G protein-coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled serotonin receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables G protein-coupled serotonin receptor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables serotonin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables serotonin binding IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
5-hydroxytryptamine receptor 1E
Names
5-HT-1E
5-hydroxytryptamine (serotonin) receptor 1E, G protein-coupled
S31
serotonin receptor 1E

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000865.3NP_000856.1  5-hydroxytryptamine receptor 1E

    See identical proteins and their annotated locations for NP_000856.1

    Status: VALIDATED

    Source sequence(s)
    AL157777, AL521170, BC069751, M91467
    Consensus CDS
    CCDS5006.1
    UniProtKB/Swiss-Prot
    P28566
    Related
    ENSP00000307766.4, ENST00000305344.7
    Conserved Domains (1) summary
    cd15335
    Location:23355
    7tmA_5-HT1E; serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    86937528..87016679
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011535789.3XP_011534091.1  5-hydroxytryptamine receptor 1E isoform X1

    See identical proteins and their annotated locations for XP_011534091.1

    UniProtKB/Swiss-Prot
    P28566
    Conserved Domains (1) summary
    cd15335
    Location:23355
    7tmA_5-HT1E; serotonin receptor subtype 1E, member of the class A family of seven-transmembrane G protein-coupled receptors

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    88146245..88225391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)