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Uch Ubiquitin carboxy-terminal hydrolase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 33397, updated on 10-May-2024

Summary

Official Symbol
Uchprovided by FlyBase
Official Full Name
Ubiquitin carboxy-terminal hydrolaseprovided by FlyBase
Primary source
FLYBASE:FBgn0010288
Locus tag
Dmel_CG4265
See related
AllianceGenome:FB:FBgn0010288
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
cg4265; CG4265; Dmel\CG4265; dUch; dUCH; P35122; UBL; uch; UCH; uch-D; Uch-D; UCH-D; UCH-D19; UCH-L1; Uchl; Uchl1; UCHL1
Summary
Enables thiol-dependent deubiquitinase. Involved in protein deubiquitination. Predicted to be active in cytoplasm. Is expressed in adult head; nurse cell; oocyte; organism; and spermatocyte. Used to study Parkinson's disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; Parkinson's disease; and hereditary spastic paraplegia. Orthologous to several human genes including UCHL1 (ubiquitin C-terminal hydrolase L1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See Uch in Genome Data Viewer
Location:
22D4-22D4; 2-5 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2212738..2214211, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2212738..2214211, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene daedalus Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
ubiquitin carboxy-terminal hydrolase
Names
CG4265-PA
CG4265-PB
CG4265-PC
Uch-PA
Uch-PB
Uch-PC
ubiquitin C-terminal hydrolase
ubiquitin carboxyl terminal hydrolase
ubiquitin carboxyterminal hydrolase
NP_001188681.1
NP_001259915.1
NP_476940.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    2212738..2214211 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057592.4NP_476940.1  ubiquitin carboxy-terminal hydrolase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476940.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P35122, Q4PIX7, Q9TWA0, Q9V417
    UniProtKB/TrEMBL
    M9MRD0
    Related
    FBpp0077516
    Conserved Domains (1) summary
    cd09616
    Location:4222
    Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3
  2. NM_001272986.1NP_001259915.1  ubiquitin carboxy-terminal hydrolase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001259915.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PE40
    Conserved Domains (1) summary
    cd09616
    Location:4219
    Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3
  3. NM_001201752.2NP_001188681.1  ubiquitin carboxy-terminal hydrolase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188681.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P35122, Q4PIX7, Q9TWA0, Q9V417
    UniProtKB/TrEMBL
    M9MRD0
    Conserved Domains (1) summary
    cd09616
    Location:4222
    Peptidase_C12_UCH_L1_L3; Cysteine peptidase C12 containing ubiquitin carboxyl-terminal hydrolase (UCH) families L1 and L3