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DNAJC4 DnaJ heat shock protein family (Hsp40) member C4 [ Homo sapiens (human) ]

Gene ID: 3338, updated on 11-Jun-2021

Summary

Official Symbol
DNAJC4provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member C4provided by HGNC
Primary source
HGNC:HGNC:5271
See related
Ensembl:ENSG00000110011 MIM:604189
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSPF2; MCG18; DANJC4
Expression
Broad expression in testis (RPKM 43.6), spleen (RPKM 17.2) and 25 other tissues See more
Orthologs
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Genomic context

See DNAJC4 in Genome Data Viewer
Location:
11q13.1
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (64230432..64234281)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (63997904..64001753)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene FERM domain containing kindlin 3 Neighboring gene tRNA phosphotransferase 1 Neighboring gene nudix hydrolase 22 Neighboring gene vascular endothelial growth factor B Neighboring gene Uncharacterized protein LOC114841035 Neighboring gene FKBP prolyl isomerase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC19482, MGC57189, MGC71863

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables unfolded protein binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in protein folding NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to unfolded protein TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
dnaJ homolog subfamily C member 4
Names
DnaJ (Hsp40) homolog, subfamily C, member 4
dnaJ-like protein HSPF2
heat shock 40kD protein 2
multiple endocrine neoplasia type 1 candidate protein number 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001307980.1NP_001294909.1  dnaJ homolog subfamily C member 4 isoform 1

    See identical proteins and their annotated locations for NP_001294909.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF036874, AP001453, BC032137, BC044584
    Consensus CDS
    CCDS76424.1
    UniProtKB/Swiss-Prot
    Q9NNZ3
    UniProtKB/TrEMBL
    J3KNJ8, Q6PIN0
    Related
    ENSP00000320548.5, ENST00000321460.5
    Conserved Domains (1) summary
    pfam00226
    Location:3496
    DnaJ; DnaJ domain
  2. NM_001307981.1NP_001294910.1  dnaJ homolog subfamily C member 4 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site at an internal exon. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AP001453, BC044584, BC051008
    UniProtKB/Swiss-Prot
    Q9NNZ3
    UniProtKB/TrEMBL
    Q86VG4
    Conserved Domains (1) summary
    pfam00226
    Location:3496
    DnaJ; DnaJ domain
  3. NM_005528.4NP_005519.2  dnaJ homolog subfamily C member 4 isoform 3

    See identical proteins and their annotated locations for NP_005519.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' and 3' UTRs and uses alternate splice sites in the 3' coding region, resulting in a frameshift and novel 3' coding region compared to variant 1. It encodes isoform 3, which is shorter than and has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC053947
    Consensus CDS
    CCDS41666.1
    UniProtKB/Swiss-Prot
    Q9NNZ3
    Related
    ENSP00000396896.2, ENST00000321685.7
    Conserved Domains (1) summary
    pfam00226
    Location:3496
    DnaJ; DnaJ domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    64230432..64234281
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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