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Cngb1 cyclic nucleotide gated channel beta 1 [ Mus musculus (house mouse) ]

Gene ID: 333329, updated on 11-Apr-2024

Summary

Official Symbol
Cngb1provided by MGI
Official Full Name
cyclic nucleotide gated channel beta 1provided by MGI
Primary source
MGI:MGI:2664102
See related
Ensembl:ENSMUSG00000031789 AllianceGenome:MGI:2664102
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Garp2; Cngb1b; Gm1959
Summary
Enables cyclic nucleotide-gated ion channel activity. Involved in several processes, including detection of chemical stimulus involved in sensory perception of smell; ion channel modulating, G protein-coupled receptor signaling pathway; and response to odorant. Acts upstream of or within several processes, including photoreceptor cell maintenance; photoreceptor cell outer segment organization; and sensory perception of smell. Located in membrane and photoreceptor outer segment. Is expressed in several structures, including head mesenchyme; incisor; limb; sensory organ; and skeleton. Used to study retinitis pigmentosa. Human ortholog(s) of this gene implicated in retinitis pigmentosa and retinitis pigmentosa 45. Orthologous to human CNGB1 (cyclic nucleotide gated channel subunit beta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

Location:
8 C5; 8 47.12 cM
Exon count:
36
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (95965671..96033213, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (95239043..95306585, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene kinesin family member C3 Neighboring gene predicted gene, 31036 Neighboring gene STARR-seq mESC enhancer starr_22381 Neighboring gene predicted gene, 31277 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:97769227-97769421 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:97771323-97771506 Neighboring gene STARR-positive B cell enhancer ABC_E3796 Neighboring gene microtubule-associated protein 1 light chain 3 pseudogene copy 6 Neighboring gene sperm microtubule inner protein 8 Neighboring gene zinc finger protein 319

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Chemically induced (ENU) (1) 
  • Endonuclease-mediated (3) 

General gene information

Markers

Clone Names

  • MGC27656

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cAMP binding ISO
Inferred from Sequence Orthology
more info
 
enables cGMP binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cGMP binding ISO
Inferred from Sequence Orthology
more info
 
enables cyclic nucleotide-activated monoatomic ion channel activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables intracellularly cAMP-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables intracellularly cAMP-activated cation channel activity ISO
Inferred from Sequence Orthology
more info
 
enables intracellularly cGMP-activated cation channel activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables intracellularly cGMP-activated cation channel activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in detection of chemical stimulus involved in sensory perception of smell IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in detection of light stimulus involved in visual perception ISO
Inferred from Sequence Orthology
more info
 
involved_in ion channel modulating, G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in membrane depolarization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in monoatomic cation transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in monoatomic cation transport ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of olfactory nerve maturation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within photoreceptor cell maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within photoreceptor cell outer segment organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within phototransduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein localization to organelle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in response to odorant IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retina homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in retina homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within sensory perception of smell IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of intracellular cyclic nucleotide activated cation channel complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of intracellular cyclic nucleotide activated cation channel complex ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in photoreceptor outer segment IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in photoreceptor outer segment IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in terminal bouton ISO
Inferred from Sequence Orthology
more info
 
part_of transmembrane transporter complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
cyclic nucleotide-gated cation channel beta-1
Names
cyclic nucleotide-gated channel beta subunit 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195413.1NP_001182342.1  cyclic nucleotide-gated cation channel beta-1 isoform 1

    See identical proteins and their annotated locations for NP_001182342.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC102518, BC016201, BC045114, BC046523
    Consensus CDS
    CCDS72151.1
    UniProtKB/TrEMBL
    E1AZ71
    Related
    ENSMUSP00000113827.3, ENSMUST00000119870.9
    Conserved Domains (3) summary
    COG0664
    Location:10321165
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:10381147
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    pfam00520
    Location:756957
    Ion_trans; Ion transport protein
  2. NM_145601.1NP_663576.1  cyclic nucleotide-gated cation channel beta-1 isoform 2

    See identical proteins and their annotated locations for NP_663576.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' coding region and 3' UTR, compared to variant 1. The resulting isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    BC016201
    Consensus CDS
    CCDS52641.1
    UniProtKB/TrEMBL
    Q91WA8
    Related
    ENSMUSP00000090956.5, ENSMUST00000093268.5

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    95965671..96033213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531140.4XP_006531203.1  cyclic nucleotide-gated cation channel beta-1 isoform X1

    UniProtKB/TrEMBL
    E9PXX0, Q80XL8
    Related
    ENSMUSP00000113750.3, ENSMUST00000120044.9
    Conserved Domains (2) summary
    PLN03192
    Location:265651
    PLN03192; Voltage-dependent potassium channel; Provisional
    cd00038
    Location:579688
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
  2. XM_036154139.1XP_036010032.1  cyclic nucleotide-gated cation channel beta-1 isoform X2

    Conserved Domains (2) summary
    PLN03192
    Location:75461
    PLN03192; Voltage-dependent potassium channel; Provisional
    cd00038
    Location:389498
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...