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Dhps deoxyhypusine synthase [ Mus musculus (house mouse) ]

Gene ID: 330817, updated on 26-Sep-2022

Summary

Official Symbol
Dhpsprovided by MGI
Official Full Name
deoxyhypusine synthaseprovided by MGI
Primary source
MGI:MGI:2683592
See related
Ensembl:ENSMUSG00000060038 AllianceGenome:MGI:2683592
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Dhs
Summary
Predicted to enable deoxyhypusine synthase activity and identical protein binding activity. Acts upstream of or within glucose homeostasis; peptidyl-lysine modification to peptidyl-hypusine; and positive regulation of T cell proliferation. Predicted to be active in cytoplasm. Orthologous to human DHPS (deoxyhypusine synthase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 12.7), adrenal adult (RPKM 12.0) and 28 other tissues See more
Orthologs
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Genomic context

See Dhps in Genome Data Viewer
Location:
8; 8 C3
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85798106..85801790)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (85071486..85075162)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene F-box and WD-40 domain protein 9 Neighboring gene microRNA 7070 Neighboring gene G protein subunit gamma 14 Neighboring gene WD repeat domain containing 83 Neighboring gene WD repeat domain 83 opposite strand Neighboring gene mannosidase 2, alpha B1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC49129, MGC74384

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables deoxyhypusine synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables deoxyhypusine synthase activity ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
deoxyhypusine synthase
NP_001034603.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039514.1NP_001034603.1  deoxyhypusine synthase

    See identical proteins and their annotated locations for NP_001034603.1

    Status: VALIDATED

    Source sequence(s)
    AK159104, BB763715
    Consensus CDS
    CCDS22492.1
    UniProtKB/Swiss-Prot
    E9QM48, Q3TXU5
    Related
    ENSMUSP00000077733.7, ENSMUST00000078665.13
    Conserved Domains (1) summary
    pfam01916
    Location:45351
    DS; Deoxyhypusine synthase

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    85798106..85801790
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001778449.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_201408.1: Suppressed sequence

    Description
    NM_201408.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.