Dhps deoxyhypusine synthase [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dhpsprovided by MGI
Official Full Name: deoxyhypusine synthaseprovided by MGI
Primary source: MGI:MGI:2683592
See related: Ensembl:ENSMUSG00000060038 AllianceGenome:MGI:2683592
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dhs
Summary: Enables deoxyhypusine synthase activity. Involved in peptidyl-lysine modification to peptidyl-hypusine. Acts upstream of or within glucose homeostasis and positive regulation of T cell proliferation. Is active in cytosol. Orthologous to human DHPS (deoxyhypusine synthase). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in ovary adult (RPKM 12.7), adrenal adult (RPKM 12.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 8 C3; 8 41.55 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	8	NC_000074.7 (85798106..85801790)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	8	NC_000074.6 (85071486..85075162)

Chromosome 8 - NC_000074.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis.
Title: Deoxyhypusine synthase mutations alter the post-translational modification of eukaryotic initiation factor 5A resulting in impaired human and mouse neural homeostasis.
Deoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype.
Title: Deoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype.
Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice.
Title: Neuron-specific ablation of eIF5A or deoxyhypusine synthase leads to impairments in growth, viability, neurodevelopment, and cognitive functions in mice.
Deletion of hypusine modification enzymes ( deoxyhypusine synthase and deoxyhypusine hydroxylase )exerts strong phenotypes. eIF-5A2-deleted animals are viable and fertile.
Title: Biological Relevance and Therapeutic Potential of the Hypusine Modification System.
The results suggest a previously unrecognized role for deoxyhypusine synthase in promoting T cell proliferation and differentiation via regulation of CD25.
Title: Deoxyhypusine synthase promotes differentiation and proliferation of T helper type 1 (Th1) cells in autoimmune diabetes.
knockout of either the eIF5A-1 gene (Eif5a) or of the deoxyhypusine synthase gene (Dhps) caused early embryonic lethality in mice, indicating the essential nature of both eIF5A-1 and deoxyhypusine synthase in mammalian development
Title: Essential role of eIF5A-1 and deoxyhypusine synthase in mouse embryonic development.
Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling.
Title: Deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling.
DHS is required for the ongoing production of proteins, particularly CHOP, in response to ER stress in the beta cell.
Title: Inhibition of deoxyhypusine synthase enhances islet {beta} cell function and survival in the setting of endoplasmic reticulum stress and type 2 diabetes.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (1)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:225076

NoName (e-PCR)
- UniSTS:235949

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables deoxyhypusine synthase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deoxyhypusine synthase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables deoxyhypusine synthase activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-lysine modification to peptidyl-hypusine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within peptidyl-lysine modification to peptidyl-hypusine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-lysine modification to peptidyl-hypusine	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-lysine modification to peptidyl-hypusine	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermidine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in spermidine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in spermidine metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in spermidine metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: deoxyhypusine synthase

NP_001034603.1

EC 2.5.1.46

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039514.1 → NP_001034603.1 deoxyhypusine synthase

See identical proteins and their annotated locations for NP_001034603.1

Status: VALIDATED

Source sequence(s)

AK159104, BB763715

Consensus CDS

CCDS22492.1

UniProtKB/Swiss-Prot

E9QM48, Q3TXU5

Related

ENSMUSP00000077733.7, ENSMUST00000078665.13

Conserved Domains (1) summary

pfam01916
Location:45 → 351

DS; Deoxyhypusine synthase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000074.7 Reference GRCm39 C57BL/6J

Range

85798106..85801790

Download

GenBank, FASTA, Sequence Viewer (Graphics)

RNA

XR_001778449.3 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_201408.1: Suppressed sequence

Description

NM_201408.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.