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Spink10 serine peptidase inhibitor, Kazal type 10 [ Mus musculus (house mouse) ]

Gene ID: 328971, updated on 2-Nov-2024

Summary

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Official Symbol
Spink10provided by MGI
Official Full Name
serine peptidase inhibitor, Kazal type 10provided by MGI
Primary source
MGI:MGI:3584533
See related
Ensembl:ENSMUSG00000044176 AllianceGenome:MGI:3584533
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A230091H23Rik
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of peptidase activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in genital fat pad adult (RPKM 10.9) and testis adult (RPKM 0.8) See more
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Genomic context

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See Spink10 in Genome Data Viewer
Location:
18 E1; 18 35.22 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (62681982..62797412)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (62548873..62664341)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene 5 hydroxytryptamine (serotonin) receptor 4 Neighboring gene X-linked lymphocyte-regulated 5C pseudogene Neighboring gene F-box protein 38 Neighboring gene STARR-positive B cell enhancer ABC_E967 Neighboring gene STARR-seq mESC enhancer starr_44774 Neighboring gene serine peptidase inhibitor, Kazal type 7 (putative) Neighboring gene STARR-seq mESC enhancer starr_44775 Neighboring gene serine peptidase inhibitor, Kazal type 13 Neighboring gene STARR-seq mESC enhancer starr_44776 Neighboring gene predicted gene, 41751 Neighboring gene branched chain ketoacid dehydrogenase E1, alpha polypeptide pseudogene Neighboring gene STARR-seq mESC enhancer starr_44778 Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:62879723-62879876 Neighboring gene RIKEN cDNA 2700046A07 gene Neighboring gene predicted gene, 36598

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Novel epididymal protease inhibitors with Kazal or WAP family domain. Jalkanen J, et al. Biochem Biophys Res Commun, 2006 Oct 13. PMID 16930550
  2. Evidence Implicating CCNB1IP1, a RING Domain-Containing Protein Required for Meiotic Crossing Over in Mice, as an E3 SUMO Ligase. Strong ER, et al. Genes (Basel), 2010 Dec 2. PMID 21779533, Free PMC Article
  3. Mouse screen reveals multiple new genes underlying mouse and human hearing loss. Ingham NJ, et al. PLoS Biol, 2019 Apr. PMID 30973865, Free PMC Article
  4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine protease inhibitor Kazal-type 10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_177829.3 → NP_808497.1  serine protease inhibitor Kazal-type 10

    See identical proteins and their annotated locations for NP_808497.1

    Status: VALIDATED

    Source sequence(s)
    AK039062, AV380905
    Consensus CDS
    CCDS29293.1
    UniProtKB/Swiss-Prot
    Q8CAC8
    Related
    ENSMUSP00000062976.5, ENSMUST00000055725.12
    Conserved Domains (2) summary
    pfam00050
    Location:112 → 162
    Kazal_1; Kazal-type serine protease inhibitor domain
    cl00097
    Location:35 → 69
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    62681982..62797412
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161183.1 → XP_036017076.1  serine protease inhibitor Kazal-type 10 isoform X2

    UniProtKB/Swiss-Prot
    Q8CAC8
    Conserved Domains (2) summary
    pfam00050
    Location:112 → 162
    Kazal_1; Kazal-type serine protease inhibitor domain
    cl00097
    Location:35 → 69
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

  2. XM_036161184.1 → XP_036017077.1  serine protease inhibitor Kazal-type 10 isoform X2

    UniProtKB/Swiss-Prot
    Q8CAC8
    Conserved Domains (2) summary
    pfam00050
    Location:112 → 162
    Kazal_1; Kazal-type serine protease inhibitor domain
    cl00097
    Location:35 → 69
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

  3. XM_030250514.2 → XP_030106374.1  serine protease inhibitor Kazal-type 10 isoform X2

    UniProtKB/Swiss-Prot
    Q8CAC8
    Conserved Domains (2) summary
    pfam00050
    Location:112 → 162
    Kazal_1; Kazal-type serine protease inhibitor domain
    cl00097
    Location:35 → 69
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

  4. XM_006526029.5 → XP_006526092.1  serine protease inhibitor Kazal-type 10 isoform X1

    Conserved Domains (2) summary
    pfam00050
    Location:117 → 167
    Kazal_1; Kazal-type serine protease inhibitor domain
    cl00097
    Location:40 → 74
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

  5. XM_006526034.5 → XP_006526097.1  serine protease inhibitor Kazal-type 10 isoform X2

    See identical proteins and their annotated locations for XP_006526097.1

    UniProtKB/Swiss-Prot
    Q8CAC8
    Conserved Domains (2) summary
    pfam00050
    Location:112 → 162
    Kazal_1; Kazal-type serine protease inhibitor domain
    cl00097
    Location:35 → 69
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

  6. XM_006526033.5 → XP_006526096.1  serine protease inhibitor Kazal-type 10 isoform X2

    See identical proteins and their annotated locations for XP_006526096.1

    UniProtKB/Swiss-Prot
    Q8CAC8
    Conserved Domains (2) summary
    pfam00050
    Location:112 → 162
    Kazal_1; Kazal-type serine protease inhibitor domain
    cl00097
    Location:35 → 69
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

  7. XM_006526035.5 → XP_006526098.1  serine protease inhibitor Kazal-type 10 isoform X2

    See identical proteins and their annotated locations for XP_006526098.1

    UniProtKB/Swiss-Prot
    Q8CAC8
    Conserved Domains (2) summary
    pfam00050
    Location:112 → 162
    Kazal_1; Kazal-type serine protease inhibitor domain
    cl00097
    Location:35 → 69
    KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CAC8.1 GenPept UniProtKB/Swiss-Prot:Q8CAC8

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