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Rft1 RFT1 homolog [ Mus musculus (house mouse) ]

Gene ID: 328370, updated on 8-Jun-2024

Summary

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Official Symbol
Rft1provided by MGI
Official Full Name
RFT1 homologprovided by MGI
Primary source
MGI:MGI:3607791
See related
Ensembl:ENSMUSG00000052395 AllianceGenome:MGI:3607791
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D930025H04
Summary
Predicted to be involved in glycolipid translocation. Predicted to act upstream of or within carbohydrate transport. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including adrenal gland; brain; cardiovascular system; genitourinary system; and gut. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation In. Orthologous to human RFT1 (RFT1 homolog). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in genital fat pad adult (RPKM 5.2), subcutaneous fat pad adult (RPKM 4.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rft1 in Genome Data Viewer
Location:
14 B; 14 18.9 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (30375041..30413274)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (30654340..30691317)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2422 Neighboring gene predicted gene, 52147 Neighboring gene protein kinase C, delta Neighboring gene STARR-positive B cell enhancer ABC_E7301 Neighboring gene predicted gene, 53839 Neighboring gene STARR-positive B cell enhancer ABC_E4101 Neighboring gene STARR-positive B cell enhancer ABC_E1892 Neighboring gene STARR-seq mESC enhancer starr_36309 Neighboring gene Scm-like with four mbt domains 1 Neighboring gene RIKEN cDNA 1700087M22 gene Neighboring gene transformer 2 beta homolog pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
  2. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
  3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
  4. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within carbohydrate transport IEA
Inferred from Electronic Annotation
more info
  
involved_in dolichol-linked oligosaccharide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycolipid translocation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1; protein RFT1 homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001425843.1 → NP_001412772.1  man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC154436, AC154646
    UniProtKB/TrEMBL
    B7ZP34

  2. NM_001425844.1 → NP_001412773.1  man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC154436, AC154646
    UniProtKB/TrEMBL
    B7ZP34

  3. NM_001425845.1 → NP_001412774.1  man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC154436, AC154646
    UniProtKB/TrEMBL
    B7ZP34

  4. NM_001425846.1 → NP_001412775.1  man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC154436, AC154646

  5. NM_001425847.1 → NP_001412776.1  man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC154436, AC154646

  6. NM_177815.4 → NP_808483.2  man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 isoform 1

    See identical proteins and their annotated locations for NP_808483.2

    Status: VALIDATED

    Source sequence(s)
    AC154436, AC154646
    Consensus CDS
    CCDS26896.1
    UniProtKB/Swiss-Prot
    B2RUN9, Q8C3B8
    UniProtKB/TrEMBL
    B7ZP34
    Related
    ENSMUSP00000064153.8, ENSMUST00000064230.16
    Conserved Domains (1) summary
    pfam04506
    Location:11 → 524
    Rft-1; Rft protein

RNA

  1. NR_189624.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154436, AC154646

  2. NR_189625.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154436, AC154646
    Related
    ENSMUST00000228686.2

  3. NR_189626.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC154436, AC154646

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    30375041..30413274
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017316058.3 → XP_017171547.1  protein RFT1 homolog isoform X1

    Conserved Domains (1) summary
    cl09326
    Location:9 → 261
    MATE_like; Multidrug and toxic compound extrusion family and similar proteins

RNA

  1. XR_001781128.3 RNA Sequence

  2. XR_383188.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8C3B8.2 GenPept UniProtKB/Swiss-Prot:Q8C3B8

Gene LinkOut

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