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Pigl phosphatidylinositol glycan anchor biosynthesis, class L [ Mus musculus (house mouse) ]

Gene ID: 327942, updated on 17-Aug-2024

Summary

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Official Symbol
Piglprovided by MGI
Official Full Name
phosphatidylinositol glycan anchor biosynthesis, class Lprovided by MGI
Primary source
MGI:MGI:2681271
See related
Ensembl:ENSMUSG00000014245 AllianceGenome:MGI:2681271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm737
Summary
Predicted to enable N-acetylglucosaminylphosphatidylinositol deacetylase activity. Predicted to be involved in GPI anchor biosynthetic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in CHIME syndrome. Orthologous to human PIGL (phosphatidylinositol glycan anchor biosynthesis class L). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in large intestine adult (RPKM 6.3), subcutaneous fat pad adult (RPKM 5.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B2; 11 38.34 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (62349267..62406863)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (62458441..62516037)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 19 Neighboring gene anaphase-promoting complex subunit 15 pseudogene Neighboring gene nuclear receptor co-repressor 1 Neighboring gene STARR-seq mESC enhancer starr_29697 Neighboring gene STARR-seq mESC enhancer starr_29699 Neighboring gene STARR-seq mESC enhancer starr_29702 Neighboring gene STARR-seq mESC enhancer starr_29703 Neighboring gene STARR-seq mESC enhancer starr_29704 Neighboring gene STARR-seq mESC enhancer starr_29710 Neighboring gene STARR-seq mESC enhancer starr_29712 Neighboring gene STARR-seq mESC enhancer starr_29713 Neighboring gene centromere protein V Neighboring gene predicted gene 12279

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Placentation defects are highly prevalent in embryonic lethal mouse mutants. Perez-Garcia V, et al. Nature, 2018 Mar 22. PMID 29539633, Free PMC Article
  2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
  3. EUCOMM--the European conditional mouse mutagenesis program. Friedel RH, et al. Brief Funct Genomic Proteomic, 2007 Sep. PMID 17967808
  4. A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome. Hansen J, et al. Proc Natl Acad Sci U S A, 2003 Aug 19. PMID 12904583, Free PMC Article
  5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 
  • Gene trapped (1) 
  • Targeted (2) 

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC106811

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables N-acetylglucosaminylphosphatidylinositol deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables N-acetylglucosaminylphosphatidylinositol deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in GPI anchor biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in preassembly of GPI anchor in ER membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase
Names
ortholog of human and rat phosphatidylinositol glycan class L PIGL
phosphatidylinositol-glycan biosynthesis class L protein
NP_001034625.1
NP_001351700.1
XP_036012661.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001039536.4 → NP_001034625.1  N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase isoform 1

    See identical proteins and their annotated locations for NP_001034625.1

    Status: VALIDATED

    Source sequence(s)
    AL596181, BX248411, BX470084
    Consensus CDS
    CCDS24824.1
    UniProtKB/Swiss-Prot
    Q5SX19
    Related
    ENSMUSP00000014389.6, ENSMUST00000014389.6
    Conserved Domains (1) summary
    COG2120
    Location:37 → 252
    LmbE; N-acetylglucosaminyl deacetylase, LmbE family [Carbohydrate transport and metabolism]

  2. NM_001364771.2 → NP_001351700.1  N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase isoform 2

    Status: VALIDATED

    Source sequence(s)
    BX248411, CR392047
    UniProtKB/TrEMBL
    Q4V9U8
    Conserved Domains (1) summary
    cl00929
    Location:45 → 79
    PIG-L; GlcNAc-PI de-N-acetylase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    62349267..62406863
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156768.1 → XP_036012661.1  N-acetylglucosaminyl-phosphatidylinositol de-N-acetylase isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_199026.1: Suppressed sequence

    Description
    NM_199026.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5SX19.1 GenPept UniProtKB/Swiss-Prot:Q5SX19

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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