U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PRMT2 protein arginine methyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 3275, updated on 19-Sep-2024

Summary

Official Symbol
PRMT2provided by HGNC
Official Full Name
protein arginine methyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:5186
See related
Ensembl:ENSG00000160310 MIM:601961; AllianceGenome:HGNC:5186
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRMT1L1
Summary
Enables several functions, including nuclear receptor binding activity; peroxisome proliferator activated receptor binding activity; and protein homodimerization activity. Involved in several processes, including histone methylation; regulation of androgen receptor signaling pathway; and regulation of transcription, DNA-templated. Located in cytosol and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 11.6), spleen (RPKM 8.9) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See PRMT2 in Genome Data Viewer
Location:
21q22.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (46635674..46665124)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (45021936..45051495)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (48055586..48085036)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene disco interacting protein 2 homolog A Neighboring gene RNA, U6 small nuclear 396, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:48026033-48026534 Neighboring gene S100 calcium binding protein B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:48044299-48044799 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:48054684-48055354 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:48061114-48061614 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13425 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18607 Neighboring gene uncharacterized LOC124905058 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:48087547-48088284 Neighboring gene DSTN pseudogene 1 Neighboring gene MPRA-validated peak4433 silencer Neighboring gene ribosomal protein L23a pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC111373

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables histone H3 methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables histone H3R8 methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables histone methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear androgen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear estrogen receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
enables nuclear estrogen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear progesterone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear retinoic acid receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables nuclear thyroid hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables peroxisome proliferator activated receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-arginine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein-arginine N-methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein-arginine omega-N asymmetric methyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein-containing complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein arginine N-methyltransferase 2
Names
HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1
HMT1 hnRNP methyltransferase-like 1
PRMT2 alpha
PRMT2 beta
PRMT2 gamma
histone-arginine N-methyltransferase PRMT2
NP_001229793.1
NP_001229794.1
NP_001229795.1
NP_001273605.1
NP_001273606.1
NP_001273607.1
NP_001526.2
NP_996845.1
XP_005261168.1
XP_006724061.1
XP_006724062.1
XP_006724063.1
XP_047296715.1
XP_047296716.1
XP_047296717.1
XP_054180436.1
XP_054180437.1
XP_054180438.1
XP_054180439.1
XP_054180440.1
XP_054180441.1
XP_054180442.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242864.3NP_001229793.1  protein arginine N-methyltransferase 2 isoform 2

    See identical proteins and their annotated locations for NP_001229793.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks 2 consecutive exons in the 3' coding region compared to variant 1. However, it maintains the reading frame and encodes a shorter isoform (2) lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    AK123650, BC100026, BQ267811, DA169949
    Consensus CDS
    CCDS56220.1
    UniProtKB/Swiss-Prot
    P55345
    Related
    ENSP00000397266.1, ENST00000440086.5
    Conserved Domains (3) summary
    cd02440
    Location:141221
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cd11806
    Location:3486
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    cl17173
    Location:110169
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_001242865.3NP_001229794.1  protein arginine N-methyltransferase 2 isoform 3

    See identical proteins and their annotated locations for NP_001229794.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has an alternate 3' terminal exon that causes a frame-shift compared to variant 1. The resulting shorter isoform (3) has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK123650, AP000339, DA169949, DA517312, DA708321, DB160043, U79286
    Consensus CDS
    CCDS56219.1
    UniProtKB/Swiss-Prot
    P55345
    Related
    ENSP00000335490.4, ENST00000334494.8
    Conserved Domains (2) summary
    cd11806
    Location:3486
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    cl17173
    Location:138210
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. NM_001242866.3NP_001229795.1  protein arginine N-methyltransferase 2 isoform 4

    See identical proteins and their annotated locations for NP_001229795.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and has an alternate 3' terminal exon compared to variant 1. The resulting isoform (4) has a shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AY786414, BM976817, BY799824, CA427786, CB045875, DA169949
    UniProtKB/TrEMBL
    A0A0S2Z3W8
    Conserved Domains (2) summary
    cd11806
    Location:3486
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    cl17173
    Location:112242
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  4. NM_001286676.2NP_001273605.1  protein arginine N-methyltransferase 2 isoform 5

    See identical proteins and their annotated locations for NP_001273605.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks 3 consecutive exons in the 3' coding region that causes a frame-shift compared to variant 1. The resulting shorter isoform (5) has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK123650, AY786414, BQ267811, DA169949, FJ436411
    Consensus CDS
    CCDS68231.1
    UniProtKB/Swiss-Prot
    P55345
    Related
    ENSP00000407463.2, ENST00000458387.6
    Conserved Domains (2) summary
    cd11806
    Location:3486
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    cl17173
    Location:138220
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  5. NM_001286677.2NP_001273606.1  protein arginine N-methyltransferase 2 isoform 6

    See identical proteins and their annotated locations for NP_001273606.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and lacks 3 consecutive exons in the 3' coding region that causes a frame-shift compared to variant 1. The resulting shorter isoform (6) has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK123650, AY786414, BQ267811, DA169949
    Consensus CDS
    CCDS68230.1
    UniProtKB/TrEMBL
    A0A0S2Z3W8
    Related
    ENSP00000411984.2, ENST00000451211.6
    Conserved Domains (3) summary
    cd02440
    Location:141241
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cd11806
    Location:3486
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    cl17173
    Location:110169
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  6. NM_001286678.2NP_001273607.1  protein arginine N-methyltransferase 2 isoform 7

    See identical proteins and their annotated locations for NP_001273607.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and lacks 4 consecutive exons in the 3' coding region compared to variant 1. However, it maintains the reading frame and encodes a shorter isoform (7) lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    AK123650, AY786414, BQ267811, DA169949
    Consensus CDS
    CCDS74806.1
    UniProtKB/TrEMBL
    A8MXR3
    Related
    ENSP00000291705.6, ENST00000291705.11
    Conserved Domains (2) summary
    cd11806
    Location:3486
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    cl17173
    Location:112223
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  7. NM_001535.5NP_001526.2  protein arginine N-methyltransferase 2 isoform 1

    See identical proteins and their annotated locations for NP_001526.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK123650, BQ267811, DA169949, X99209
    Consensus CDS
    CCDS13737.1
    UniProtKB/Swiss-Prot
    B7U630, B7U631, B7U632, P55345, P78350, Q498Y5, Q5U7D4, Q6FHF0, Q99781, Q9BW15, Q9UMC2
    UniProtKB/TrEMBL
    A0A0S2Z3N3, Q53FX4
    Related
    ENSP00000380760.2, ENST00000397638.6
    Conserved Domains (3) summary
    cd02440
    Location:141241
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cd11806
    Location:3486
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    cl17173
    Location:110169
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  8. NM_206962.4NP_996845.1  protein arginine N-methyltransferase 2 isoform 1

    See identical proteins and their annotated locations for NP_996845.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK123650, BC000727, BQ267811, DA169949
    Consensus CDS
    CCDS13737.1
    UniProtKB/Swiss-Prot
    B7U630, B7U631, B7U632, P55345, P78350, Q498Y5, Q5U7D4, Q6FHF0, Q99781, Q9BW15, Q9UMC2
    UniProtKB/TrEMBL
    A0A0S2Z3N3, Q53FX4
    Related
    ENSP00000347906.3, ENST00000355680.8
    Conserved Domains (3) summary
    cd02440
    Location:141241
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cd11806
    Location:3486
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    cl17173
    Location:110169
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    46635674..46665124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723998.5XP_006724061.1  protein arginine N-methyltransferase 2 isoform X2

    See identical proteins and their annotated locations for XP_006724061.1

    UniProtKB/Swiss-Prot
    P55345
    Conserved Domains (2) summary
    cd11806
    Location:3486
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    cl17173
    Location:138220
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_006724000.4XP_006724063.1  protein arginine N-methyltransferase 2 isoform X4

    See identical proteins and their annotated locations for XP_006724063.1

    UniProtKB/TrEMBL
    A8MXR3
    Conserved Domains (2) summary
    cd11806
    Location:3486
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    cl17173
    Location:112223
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. XM_005261111.5XP_005261168.1  protein arginine N-methyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_005261168.1

    UniProtKB/Swiss-Prot
    B7U630, B7U631, B7U632, P55345, P78350, Q498Y5, Q5U7D4, Q6FHF0, Q99781, Q9BW15, Q9UMC2
    UniProtKB/TrEMBL
    A0A0S2Z3N3, Q53FX4
    Conserved Domains (3) summary
    cd02440
    Location:141241
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cd11806
    Location:3486
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    cl17173
    Location:110169
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  4. XM_047440759.1XP_047296715.1  protein arginine N-methyltransferase 2 isoform X2

  5. XM_006723999.4XP_006724062.1  protein arginine N-methyltransferase 2 isoform X3

    Conserved Domains (3) summary
    cd02440
    Location:141222
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cd11806
    Location:3486
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    cl17173
    Location:110169
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  6. XM_047440761.1XP_047296717.1  protein arginine N-methyltransferase 2 isoform X3

  7. XM_047440760.1XP_047296716.1  protein arginine N-methyltransferase 2 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    45021936..45051495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054324462.1XP_054180437.1  protein arginine N-methyltransferase 2 isoform X2

  2. XM_054324467.1XP_054180442.1  protein arginine N-methyltransferase 2 isoform X4

    UniProtKB/TrEMBL
    A8MXR3
  3. XM_054324461.1XP_054180436.1  protein arginine N-methyltransferase 2 isoform X1

    UniProtKB/Swiss-Prot
    B7U630, B7U631, B7U632, P55345, P78350, Q498Y5, Q5U7D4, Q6FHF0, Q99781, Q9BW15, Q9UMC2
    UniProtKB/TrEMBL
    A0A0S2Z3N3, Q53FX4
  4. XM_054324463.1XP_054180438.1  protein arginine N-methyltransferase 2 isoform X2

  5. XM_054324464.1XP_054180439.1  protein arginine N-methyltransferase 2 isoform X3

  6. XM_054324466.1XP_054180441.1  protein arginine N-methyltransferase 2 isoform X3

  7. XM_054324465.1XP_054180440.1  protein arginine N-methyltransferase 2 isoform X3