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PRMT2 protein arginine methyltransferase 2 [ Homo sapiens (human) ]

Gene ID: 3275, updated on 2-Oct-2018

Summary

Official Symbol
PRMT2provided by HGNC
Official Full Name
protein arginine methyltransferase 2provided by HGNC
Primary source
HGNC:HGNC:5186
See related
Ensembl:ENSG00000160310 MIM:601961; Vega:OTTHUMG00000048806
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRMT1L1
Expression
Ubiquitous expression in ovary (RPKM 11.6), spleen (RPKM 8.9) and 25 other tissues See more
Orthologs

Genomic context

See PRMT2 in Genome Data Viewer
Location:
21q22.3
Exon count:
12
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 21 NC_000021.9 (46635156..46665685)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (48055507..48085155)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene disco interacting protein 2 homolog A Neighboring gene RNA, U6 small nuclear 396, pseudogene Neighboring gene S100 calcium binding protein B Neighboring gene destrin, actin depolymerizing factor pseudogene 1 Neighboring gene ribosomal protein L23a pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC111373

Gene Ontology Provided by GOA

Function Evidence Code Pubs
androgen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
estrogen receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
estrogen receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone methyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
histone-arginine N-methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone-arginine N-methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
peroxisome proliferator activated receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
progesterone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IPI
Inferred from Physical Interaction
more info
PubMed 
protein-arginine N-methyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
protein-arginine omega-N asymmetric methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein-containing complex binding ISS
Inferred from Sequence or Structural Similarity
more info
 
retinoic acid receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
thyroid hormone receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
developmental cell growth ISS
Inferred from Sequence or Structural Similarity
more info
 
histone arginine methylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone methylation IDA
Inferred from Direct Assay
more info
PubMed 
histone methylation ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of G1/S transition of mitotic cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of NF-kappaB transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
protein methylation TAS
Traceable Author Statement
more info
PubMed 
regulation of androgen receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription, DNA-templated IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleolus IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
protein arginine N-methyltransferase 2
Names
HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 1
HMT1 hnRNP methyltransferase-like 1
PRMT2 alpha
PRMT2 beta
PRMT2 gamma
histone-arginine N-methyltransferase PRMT2
NP_001229793.1
NP_001229794.1
NP_001229795.1
NP_001273605.1
NP_001273606.1
NP_001273607.1
NP_001526.2
NP_996845.1
XP_005261168.1
XP_006724061.1
XP_006724062.1
XP_006724063.1
XP_016883828.1
XP_016883829.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001242864.2NP_001229793.1  protein arginine N-methyltransferase 2 isoform 2

    See identical proteins and their annotated locations for NP_001229793.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks 2 consecutive exons in the 3' coding region compared to variant 1. However, it maintains the reading frame and encodes a shorter isoform (2) lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    AK123650, BC100026, BQ267811, DA169949
    Consensus CDS
    CCDS56220.1
    UniProtKB/Swiss-Prot
    P55345
    Related
    ENSP00000397266.1, OTTHUMP00000207831, ENST00000440086.5, OTTHUMT00000339691
    Conserved Domains (3) summary
    cd02440
    Location:141221
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cd11806
    Location:3486
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    cl17173
    Location:110169
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. NM_001242865.2NP_001229794.1  protein arginine N-methyltransferase 2 isoform 3

    See identical proteins and their annotated locations for NP_001229794.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has an alternate 3' terminal exon that causes a frame-shift compared to variant 1. The resulting shorter isoform (3) has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK123650, AP000339, DA169949, DA517312, DA708321, DB160043, U79286
    Consensus CDS
    CCDS56219.1
    UniProtKB/Swiss-Prot
    P55345
    Related
    ENSP00000335490.4, OTTHUMP00000046526, ENST00000334494.8, OTTHUMT00000110453
    Conserved Domains (2) summary
    cd11806
    Location:3486
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    cl17173
    Location:138210
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. NM_001242866.2NP_001229795.1  protein arginine N-methyltransferase 2 isoform 4

    See identical proteins and their annotated locations for NP_001229795.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and has an alternate 3' terminal exon compared to variant 1. The resulting isoform (4) has a shorter C-terminus compared to isoform 1.
    Source sequence(s)
    AI801643, AY786414, BM976817, BY799824, CA427786, CB045875, DA169949
    UniProtKB/Swiss-Prot
    P55345
    Conserved Domains (2) summary
    cd11806
    Location:3486
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    cl17173
    Location:112242
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  4. NM_001286676.1NP_001273605.1  protein arginine N-methyltransferase 2 isoform 5

    See identical proteins and their annotated locations for NP_001273605.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and lacks 3 consecutive exons in the 3' coding region that causes a frame-shift compared to variant 1. The resulting shorter isoform (5) has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK123650, AY786414, BQ267811, DA169949, FJ436411
    Consensus CDS
    CCDS68231.1
    UniProtKB/Swiss-Prot
    P55345
    Related
    ENSP00000407463.2, ENST00000458387.6
    Conserved Domains (2) summary
    cd11806
    Location:3486
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    cl17173
    Location:138220
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  5. NM_001286677.1NP_001273606.1  protein arginine N-methyltransferase 2 isoform 6

    See identical proteins and their annotated locations for NP_001273606.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and lacks 3 consecutive exons in the 3' coding region that causes a frame-shift compared to variant 1. The resulting shorter isoform (6) has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK123650, AY786414, BQ267811, DA169949
    Consensus CDS
    CCDS68230.1
    UniProtKB/Swiss-Prot
    P55345
    Related
    ENSP00000411984.2, ENST00000451211.6
    Conserved Domains (3) summary
    cd02440
    Location:141241
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cd11806
    Location:3486
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    cl17173
    Location:110169
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  6. NM_001286678.1NP_001273607.1  protein arginine N-methyltransferase 2 isoform 7

    See identical proteins and their annotated locations for NP_001273607.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and lacks 4 consecutive exons in the 3' coding region compared to variant 1. However, it maintains the reading frame and encodes a shorter isoform (7) lacking an internal protein segment compared to isoform 1.
    Source sequence(s)
    AK123650, AY786414, BQ267811, DA169949
    Consensus CDS
    CCDS74806.1
    UniProtKB/Swiss-Prot
    P55345
    Related
    ENSP00000291705.6, ENST00000291705.11
    Conserved Domains (2) summary
    cd11806
    Location:3486
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    cl17173
    Location:112223
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  7. NM_001535.4NP_001526.2  protein arginine N-methyltransferase 2 isoform 1

    See identical proteins and their annotated locations for NP_001526.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
    Source sequence(s)
    AK123650, BQ267811, DA169949, X99209
    Consensus CDS
    CCDS13737.1
    UniProtKB/Swiss-Prot
    P55345
    UniProtKB/TrEMBL
    A0A0S2Z3N3
    Related
    ENSP00000380760.2, OTTHUMP00000115882, ENST00000397638.6, OTTHUMT00000207402
    Conserved Domains (3) summary
    cd02440
    Location:141241
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cd11806
    Location:3486
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    cl17173
    Location:110169
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  8. NM_206962.3NP_996845.1  protein arginine N-methyltransferase 2 isoform 1

    See identical proteins and their annotated locations for NP_996845.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1). Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    AK123650, BC000727, BQ267811, DA169949
    Consensus CDS
    CCDS13737.1
    UniProtKB/Swiss-Prot
    P55345
    UniProtKB/TrEMBL
    A0A0S2Z3N3
    Related
    ENSP00000347906.3, OTTHUMP00000046525, ENST00000355680.7, OTTHUMT00000110452
    Conserved Domains (3) summary
    cd02440
    Location:141241
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cd11806
    Location:3486
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    cl17173
    Location:110169
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p12 Primary Assembly

    Range
    46635156..46665685
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005261111.4XP_005261168.1  protein arginine N-methyltransferase 2 isoform X1

    See identical proteins and their annotated locations for XP_005261168.1

    UniProtKB/Swiss-Prot
    P55345
    UniProtKB/TrEMBL
    A0A0S2Z3N3
    Conserved Domains (3) summary
    cd02440
    Location:141241
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cd11806
    Location:3486
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    cl17173
    Location:110169
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  2. XM_006723998.4XP_006724061.1  protein arginine N-methyltransferase 2 isoform X2

    See identical proteins and their annotated locations for XP_006724061.1

    UniProtKB/Swiss-Prot
    P55345
    Conserved Domains (2) summary
    cd11806
    Location:3486
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    cl17173
    Location:138220
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  3. XM_006724000.3XP_006724063.1  protein arginine N-methyltransferase 2 isoform X5

    See identical proteins and their annotated locations for XP_006724063.1

    UniProtKB/Swiss-Prot
    P55345
    Conserved Domains (2) summary
    cd11806
    Location:3486
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    cl17173
    Location:112223
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
  4. XM_017028339.2XP_016883828.1  protein arginine N-methyltransferase 2 isoform X4

  5. XM_017028340.2XP_016883829.1  protein arginine N-methyltransferase 2 isoform X4

  6. XM_006723999.3XP_006724062.1  protein arginine N-methyltransferase 2 isoform X3

    Conserved Domains (3) summary
    cd02440
    Location:141222
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    cd11806
    Location:3486
    SH3_PRMT2; Src homology 3 domain of Protein arginine N-methyltransferase 2
    cl17173
    Location:110169
    AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

RNA

  1. XR_001754841.2 RNA Sequence

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