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polr1a RNA polymerase I subunit A [ Danio rerio (zebrafish) ]

Gene ID: 327078, updated on 2-Oct-2022

Summary

Official Symbol
polr1aprovided by ZNC
Official Full Name
RNA polymerase I subunit Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-030131-5286
See related
Ensembl:ENSDARG00000098375 AllianceGenome:ZFIN:ZDB-GENE-030131-5286
Gene type
protein coding
RefSeq status
MODEL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cb934; fa26a03; sb:cb935; wu:fa26a03
Summary
Predicted to enable DNA binding activity; nucleotidyltransferase activity; and zinc ion binding activity. Predicted to contribute to DNA-directed 5'-3' RNA polymerase activity. Acts upstream of or within embryonic viscerocranium morphogenesis; neural crest cell development; and rRNA transcription. Predicted to be located in nucleus. Predicted to be part of RNA polymerase I complex. Is expressed in several structures, including alar plate midbrain region; digestive system; nervous system; pectoral fin musculature; and segmental plate. Used to study acrofacial dysostosis Cincinnati type. Human ortholog(s) of this gene implicated in acrofacial dysostosis Cincinnati type. Orthologous to human POLR1A (RNA polymerase I subunit A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See polr1a in Genome Data Viewer
Location:
chromosome: 14
Exon count:
34
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 14 NC_007125.7 (16151639..16210891)
105 previous assembly GRCz10 (GCF_000002035.5) 14 NC_007125.6 (15846073..15905327)
103 previous assembly Zv9 (GCF_000002035.4) 14 NC_007125.5 (20081191..20140593)

Chromosome 14 - NC_007125.7Genomic Context describing neighboring genes Neighboring gene inner membrane protein, mitochondrial (mitofilin) Neighboring gene pentatricopeptide repeat domain 3 Neighboring gene si:ch73-87e17.1 Neighboring gene pre-mRNA processing factor 19

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
contributes_to DNA-directed 5'-3' RNA polymerase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of RNA polymerase I complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
DNA-directed RNA polymerase I subunit RPA1
Names
polymerase (RNA) I polypeptide A, 194kDa
XP_001922839.2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007125.7 Reference GRCz11 Primary Assembly

    Range
    16151639..16210891
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001922804.6XP_001922839.2  DNA-directed RNA polymerase I subunit RPA1

    UniProtKB/TrEMBL
    A0A0R4I9V4
    Related
    ENSDARP00000130633.1, ENSDART00000160973.3
    Conserved Domains (4) summary
    cd02735
    Location:11921689
    RNAP_I_Rpa1_C; Largest subunit (Rpa1) of Eukaryotic RNA polymerase I (RNAP I), C-terminal domain
    cd01435
    Location:16997
    RNAP_I_RPA1_N; Largest subunit (RPA1) of eukaryotic RNA polymerase I (RNAP I), N-terminal domain
    TIGR02390
    Location:101024
    RNA_pol_rpoA1; DNA-directed RNA polymerase subunit A'
    pfam04998
    Location:9511644
    RNA_pol_Rpb1_5; RNA polymerase Rpb1, domain 5