Format

Send to:

Choose Destination

HRH1 histamine receptor H1 [ Homo sapiens (human) ]

Gene ID: 3269, updated on 8-Jul-2018
Official Symbol
HRH1provided by HGNC
Official Full Name
histamine receptor H1provided by HGNC
Primary source
HGNC:HGNC:5182
See related
Ensembl:ENSG00000196639 MIM:600167; Vega:OTTHUMG00000129719
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
H1R; H1-R; HH1R; hisH1
Summary
Histamine is a ubiquitous messenger molecule released from mast cells, enterochromaffin-like cells, and neurons. Its various actions are mediated by histamine receptors H1, H2, H3 and H4. The protein encoded by this gene is an integral membrane protein and belongs to the G protein-coupled receptor superfamily. It mediates the contraction of smooth muscles, the increase in capillary permeability due to contraction of terminal venules, the release of catecholamine from adrenal medulla, and neurotransmission in the central nervous system. It has been associated with multiple processes, including memory and learning, circadian rhythm, and thermoregulation. It is also known to contribute to the pathophysiology of allergic diseases such as atopic dermatitis, asthma, anaphylaxis and allergic rhinitis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2015]
Expression
Ubiquitous expression in brain (RPKM 4.0), urinary bladder (RPKM 3.8) and 21 other tissues See more
Orthologs
See HRH1 in Genome Data Viewer
Location:
3p25.3
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (11137093..11263253)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (11178779..11304939)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene SLC6A1 antisense RNA 1 Neighboring gene solute carrier family 6 member 1 Neighboring gene uncharacterized LOC101927467 Neighboring gene uncharacterized LOC105376951 Neighboring gene uncharacterized LOC102723663 Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 4 pseudogene 4 Neighboring gene autophagy related 7 Neighboring gene uncharacterized LOC105376952 Neighboring gene vestigial like family member 4

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

NHGRI GWAS Catalog

Description
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
NHGRI GWA Catalog
  • Amine ligand-binding receptors, organism-specific biosystem (from REACTOME)
    Amine ligand-binding receptors, organism-specific biosystemThe class A (rhodopsin-like) GPCRs that bind to classical biogenic amine ligands are annotated here. The amines involved (acetylcholine, adrenaline, noradrenaline, dopamine, serotonin and histamine)...
  • Calcium signaling pathway, organism-specific biosystem (from KEGG)
    Calcium signaling pathway, organism-specific biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Calcium signaling pathway, conserved biosystem (from KEGG)
    Calcium signaling pathway, conserved biosystemCa2+ that enters the cell from the outside is a principal source of signal Ca2+. Entry of Ca2+ is driven by the presence of a large electrochemical gradient across the plasma membrane. Cells use this...
  • Class A/1 (Rhodopsin-like receptors), organism-specific biosystem (from REACTOME)
    Class A/1 (Rhodopsin-like receptors), organism-specific biosystemRhodopsin-like receptors (class A/1) are the largest group of GPCRs and are the best studied group from a functional and structural point of view. They show great diversity at the sequence level and ...
  • G alpha (q) signalling events, organism-specific biosystem (from REACTOME)
    G alpha (q) signalling events, organism-specific biosystemThe classic signalling route for G alpha (q) is activation of phospholipase C beta thereby triggering phosphoinositide hydrolysis, calcium mobilization and protein kinase C activation. This provides ...
  • GPCR downstream signaling, organism-specific biosystem (from REACTOME)
    GPCR downstream signaling, organism-specific biosystemG protein-coupled receptors (GPCRs) are classically defined as the receptor, G-protein and downstream effectors, the alpha subunit of the G-protein being the primary signaling molecule. However, it h...
  • GPCR ligand binding, organism-specific biosystem (from REACTOME)
    GPCR ligand binding, organism-specific biosystemThere are more than 800 G-protein coupled receptor (GPCRs) in the human genome, making it the largest receptor superfamily. GPCRs are also the largest class of drug targets, involved in virtually all...
  • GPCRs, Class A Rhodopsin-like, organism-specific biosystem (from WikiPathways)
    GPCRs, Class A Rhodopsin-like, organism-specific biosystemThis pathway was created using the GPCRDB (Horn et al., 1998), http://www.gpcr.org/7tm/ (originally at http://www.cmbi.kun.nl/7tm/). The groupings are based on the GPCR phylogenetic tree available fr...
  • Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystem (from REACTOME)
    Gastrin-CREB signalling pathway via PKC and MAPK, organism-specific biosystemGastrin is a hormone whose main function is to stimulate secretion of hydrochloric acid by the gastric mucosa, which results in gastrin formation inhibition. This hormone also acts as a mitogenic fac...
  • Histamine receptors, organism-specific biosystem (from REACTOME)
    Histamine receptors, organism-specific biosystemHistamine is a biogenic amine involved in local immune responses, regulation of gut function and neurotransmission. It exerts its actions by binding to histamine receptors. There are four receptors i...
  • IL-4 Signaling Pathway, organism-specific biosystem (from WikiPathways)
    IL-4 Signaling Pathway, organism-specific biosystemIL-4 is a glycoprotein which is composed of 129 amino acids and has a molecular weight of 20kDa. IL-4 and IL-13 are produced by CD4+ cells and exhibit significant functional overlap. Both these cytok...
  • Inflammatory mediator regulation of TRP channels, organism-specific biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, organism-specific biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Inflammatory mediator regulation of TRP channels, conserved biosystem (from KEGG)
    Inflammatory mediator regulation of TRP channels, conserved biosystemThe TRP channels that exhibit a unique response to temperature have been given the name thermo-TRPs. Among all thermo- TRP channels, TRPV1-4, TRPM8, and TRPA1 are expressed in subsets of nociceptive...
  • Monoamine GPCRs, organism-specific biosystem (from WikiPathways)
    Monoamine GPCRs, organism-specific biosystem
    Monoamine GPCRs
  • Neuroactive ligand-receptor interaction, organism-specific biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, organism-specific biosystem
    Neuroactive ligand-receptor interaction
  • Neuroactive ligand-receptor interaction, conserved biosystem (from KEGG)
    Neuroactive ligand-receptor interaction, conserved biosystem
    Neuroactive ligand-receptor interaction
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by GPCR, organism-specific biosystem (from REACTOME)
    Signaling by GPCR, organism-specific biosystemG protein-coupled receptors (GPCRs; 7TM receptors; seven transmembrane domain receptors; heptahelical receptors; G protein-linked receptors [GPLR]) are the largest family of transmembrane receptors i...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G-protein coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
G-protein coupled receptor activity TAS
Traceable Author Statement
more info
PubMed 
G-protein coupled serotonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histamine receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
neurotransmitter receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
G-protein coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
G-protein coupled receptor signaling pathway TAS
Traceable Author Statement
more info
 
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to histamine ISS
Inferred from Sequence or Structural Similarity
more info
 
chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
eosinophil chemotaxis IEA
Inferred from Electronic Annotation
more info
 
inflammatory response TAS
Traceable Author Statement
more info
PubMed 
inositol phosphate-mediated signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
memory IEA
Inferred from Electronic Annotation
more info
 
modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phospholipase C-activating G-protein coupled receptor signaling pathway TAS
Traceable Author Statement
more info
PubMed 
positive regulation of inositol trisphosphate biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of vasoconstriction IEA
Inferred from Electronic Annotation
more info
 
regulation of synaptic plasticity IEA
Inferred from Electronic Annotation
more info
 
regulation of vascular permeability IEA
Inferred from Electronic Annotation
more info
 
regulation of vasoconstriction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
visual learning IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
Preferred Names
histamine H1 receptor
Names
histamine receptor, subclass H1

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000861.3NP_000852.1  histamine H1 receptor

    See identical proteins and their annotated locations for NP_000852.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4), also known as H/I/K, differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AC083855, BC060802, BM905371, D28481, DB073635
    Consensus CDS
    CCDS2604.1
    UniProtKB/Swiss-Prot
    P35367
    Related
    ENSP00000380247.1, OTTHUMP00000160133, ENST00000397056.1, OTTHUMT00000251928
    Conserved Domains (2) summary
    pfam00001
    Location:45220
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:34162
    7tm_4; Olfactory receptor
  2. NM_001098211.1NP_001091681.1  histamine H1 receptor

    See identical proteins and their annotated locations for NP_001091681.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3), also known as F/K, differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AC083855, BM905371, D28481, DA372691, DB073635
    Consensus CDS
    CCDS2604.1
    UniProtKB/Swiss-Prot
    P35367
    Conserved Domains (2) summary
    pfam00001
    Location:45220
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:34162
    7tm_4; Olfactory receptor
  3. NM_001098212.1NP_001091682.1  histamine H1 receptor

    See identical proteins and their annotated locations for NP_001091682.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), also known as B/K, differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same protein.
    Source sequence(s)
    AC083855, BM905371, BP366267, D28481
    Consensus CDS
    CCDS2604.1
    UniProtKB/Swiss-Prot
    P35367
    Related
    ENSP00000397028.2, OTTHUMP00000207583, ENST00000431010.2, OTTHUMT00000339090
    Conserved Domains (2) summary
    pfam00001
    Location:45220
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:34162
    7tm_4; Olfactory receptor
  4. NM_001098213.1NP_001091683.1  histamine H1 receptor

    See identical proteins and their annotated locations for NP_001091683.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), also known as A/K, represents the longest transcript. Variants 1-4 encode the same protein.
    Source sequence(s)
    AC083855, BM905371, D28481, DB073635, DC300229
    Consensus CDS
    CCDS2604.1
    UniProtKB/Swiss-Prot
    P35367
    Related
    ENSP00000406705.2, OTTHUMP00000207582, ENST00000438284.2, OTTHUMT00000339089
    Conserved Domains (2) summary
    pfam00001
    Location:45220
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:34162
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    11137093..11263253
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011533653.2XP_011531955.1  histamine H1 receptor isoform X1

    See identical proteins and their annotated locations for XP_011531955.1

    UniProtKB/Swiss-Prot
    P35367
    Conserved Domains (2) summary
    pfam00001
    Location:45220
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:34162
    7tm_4; Olfactory receptor
  2. XM_017006284.1XP_016861773.1  histamine H1 receptor isoform X1

    UniProtKB/Swiss-Prot
    P35367
    Conserved Domains (2) summary
    pfam00001
    Location:45220
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:34162
    7tm_4; Olfactory receptor
  3. XM_011533652.1XP_011531954.1  histamine H1 receptor isoform X1

    See identical proteins and their annotated locations for XP_011531954.1

    UniProtKB/Swiss-Prot
    P35367
    Conserved Domains (2) summary
    pfam00001
    Location:45220
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:34162
    7tm_4; Olfactory receptor
  4. XM_017006283.1XP_016861772.1  histamine H1 receptor isoform X1

    UniProtKB/Swiss-Prot
    P35367
    Conserved Domains (2) summary
    pfam00001
    Location:45220
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:34162
    7tm_4; Olfactory receptor
Support Center