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Rbp1-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 32293, updated on 4-Apr-2024

Summary

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Official Symbol
Rbp1-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0030479
Locus tag
Dmel_CG1987
See related
AllianceGenome:FB:FBgn0030479
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:RE47308; BEST:HL02433; CG1987; Dmel\CG1987; i159; RBP1-like; Rbp1L
Summary
Enables mRNA binding activity. Involved in RNA splicing and regulation of RNA metabolic process. Part of precatalytic spliceosome. Is expressed in adult heart and organism. Orthologous to human SRSF3 (serine and arginine rich splicing factor 3) and SRSF7 (serine and arginine rich splicing factor 7). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
11F1-11F1; 1-43 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (13380166..13384877, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (13274199..13278910, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene doublesex-Mab related 11E Neighboring gene uncharacterized protein Neighboring gene Tim9a Neighboring gene Yippee

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The SR proteins SF2 and RBP1 regulate triglyceride storage in the fat body of Drosophila. Bennick RA, et al. Biochem Biophys Res Commun, 2019 Aug 27. PMID 31277943
  2. The SR protein B52/SRp55 regulates splicing of the period thermosensitive intron and mid-day siesta in Drosophila. Zhang Z, et al. Sci Rep, 2018 Jan 30. PMID 29382842, Free PMC Article
  3. Negative feedback regulation among SR splicing factors encoded by Rbp1 and Rbp1-like in Drosophila. Kumar S, et al. EMBO J, 2005 Jul 20. PMID 15961996, Free PMC Article
  4. Genetic variation in the Yolk protein expression network of Drosophila melanogaster: sex-biased negative correlations with longevity. Tarone AM, et al. Heredity (Edinb), 2012 Oct. PMID 22760232, Free PMC Article
  5. A regulator of Dscam mutually exclusive splicing fidelity. Olson S, et al. Nat Struct Mol Biol, 2007 Dec. PMID 21188797, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rbp1-like negatively autoregulates and crossregulates at the level of alternative 3' splice site selection.
    Title: Negative feedback regulation among SR splicing factors encoded by Rbp1 and Rbp1-like in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of mRNA 3'-end processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcriptional start site selection at RNA polymerase II promoter IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of precatalytic spliceosome HDA PubMed 

General protein information

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Preferred Names
Rbp1-like
Names
CG1987-PA
CG1987-PB
CG1987-PC
Rbp1-like-PA
Rbp1-like-PB
Rbp1-like-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    13380166..13384877 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001298278.1 → NP_001285207.1  Rbp1-like, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001285207.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYD8
    Conserved Domains (2) summary
    COG0724
    Location:11 → 81
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12373
    Location:12 → 81
    RRM_SRSF3_like; RNA recognition motif in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins

  2. NM_132652.4 → NP_572880.2  Rbp1-like, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572880.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VYD8
    Related
    FBpp0073621
    Conserved Domains (2) summary
    COG0724
    Location:11 → 81
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12373
    Location:12 → 81
    RRM_SRSF3_like; RNA recognition motif in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins

  3. NM_001201656.2 → NP_001188585.1  Rbp1-like, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001188585.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9MS48
    Conserved Domains (2) summary
    COG0724
    Location:11 → 81
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12373
    Location:12 → 81
    RRM_SRSF3_like; RNA recognition motif in serine/arginine-rich splicing factor 3 (SRSF3) and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9MS48 M9MS48
Q9VYD8 Q9VYD8

Gene LinkOut

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