Format

Send to:

Choose Destination

HOXC12 homeobox C12 [ Homo sapiens (human) ]

Gene ID: 3228, updated on 18-Aug-2020

Summary

Official Symbol
HOXC12provided by HGNC
Official Full Name
homeobox C12provided by HGNC
Primary source
HGNC:HGNC:5124
See related
Ensembl:ENSG00000123407 MIM:142975
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOX3; HOC3F; HOX3F
Summary
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See HOXC12 in Genome Data Viewer
Location:
12q13.13
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (53954903..53958956)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (54348714..54350350)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984525 Neighboring gene RN7SK pseudogene 289 Neighboring gene HOXC13 antisense RNA Neighboring gene uncharacterized LOC105369775 Neighboring gene homeobox C13 Neighboring gene NUP98-HOXC11 recombination region Neighboring gene HOXC11-HOXC10 intergenic CAGE-defined high expression enhancer Neighboring gene HOX transcript antisense RNA Neighboring gene homeobox C11

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
homeobox protein Hox-C12
Names
homeo box 3F
homeo box C12
homeobox protein Hox-3F

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_173860.3NP_776272.1  homeobox protein Hox-C12

    See identical proteins and their annotated locations for NP_776272.1

    Status: REVIEWED

    Source sequence(s)
    AC012531, AH010514
    Consensus CDS
    CCDS8866.1
    UniProtKB/Swiss-Prot
    P31275
    Related
    ENSP00000243103.3, ENST00000243103.4
    Conserved Domains (1) summary
    cd00086
    Location:215271
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    53954903..53958956
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center