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HOXC10 homeobox C10 [ Homo sapiens (human) ]

Gene ID: 3226, updated on 11-Sep-2019

Summary

Official Symbol
HOXC10provided by HGNC
Official Full Name
homeobox C10provided by HGNC
Primary source
HGNC:HGNC:5122
See related
Ensembl:ENSG00000180818 MIM:605560
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HOX3I
Summary
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The protein level is controlled during cell differentiation and proliferation, which may indicate this protein has a role in origin activation. [provided by RefSeq, Jul 2008]
Expression
Biased expression in kidney (RPKM 15.8), skin (RPKM 3.7) and 5 other tissues See more
Orthologs

Genomic context

See HOXC10 in Genome Data Viewer
Location:
12q13.13
Exon count:
2
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (53985146..53990279)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (54374466..54384063)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene HOX transcript antisense RNA Neighboring gene NUP98-HOXC11 recombination region Neighboring gene homeobox C11 Neighboring gene HOXC11-HOXC10 intergenic CAGE-defined high expression enhancer Neighboring gene HOXC cluster antisense RNA 3 Neighboring gene microRNA 196a-2 Neighboring gene HOXC cluster antisense RNA 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: HOXC5

Homology

Clone Names

  • MGC5259

Gene Ontology Provided by GOA

Process Evidence Code Pubs
anterior/posterior pattern specification IEA
Inferred from Electronic Annotation
more info
 
embryonic limb morphogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of cold-induced thermogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
neuromuscular process IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
proximal/distal pattern formation IEA
Inferred from Electronic Annotation
more info
 
skeletal system development IEA
Inferred from Electronic Annotation
more info
 
spinal cord motor neuron cell fate specification IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
homeobox protein Hox-C10
Names
homeo box C10
homeobox protein Hox-3I
homeoprotein C10

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_017409.4NP_059105.2  homeobox protein Hox-C10

    See identical proteins and their annotated locations for NP_059105.2

    Status: REVIEWED

    Source sequence(s)
    AC012531, AL558161, BC001293
    Consensus CDS
    CCDS8868.1
    UniProtKB/Swiss-Prot
    Q9NYD6
    UniProtKB/TrEMBL
    Q53XI4
    Related
    ENSP00000307321.4, ENST00000303460.5
    Conserved Domains (1) summary
    pfam00046
    Location:271324
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    53985146..53990279
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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