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Bend6 BEN domain containing 6 [ Mus musculus (house mouse) ]

Gene ID: 320705, updated on 2-Nov-2024

Summary

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Official Symbol
Bend6provided by MGI
Official Full Name
BEN domain containing 6provided by MGI
Primary source
MGI:MGI:2444572
See related
Ensembl:ENSMUSG00000042182 AllianceGenome:MGI:2444572
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B230209C24Rik
Summary
Enables chromatin binding activity and transcription corepressor activity. Acts upstream of or within negative regulation of Notch signaling pathway and positive regulation of neuron differentiation. Located in nucleus. Is expressed in telencephalon. Orthologous to human BEND6 (BEN domain containing 6). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in cerebellum adult (RPKM 60.3), cortex adult (RPKM 30.9) and 4 other tissues See more
Orthologs
human all
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Genomic context

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See Bend6 in Genome Data Viewer
Location:
1 B; 1 12.85 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (33891133..33946925, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (33852052..33907933, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00543 Neighboring gene zinc finger protein 451 Neighboring gene predicted gene 15455 Neighboring gene STARR-positive B cell enhancer ABC_E7716 Neighboring gene predicted gene, 38471 Neighboring gene STARR-seq mESC enhancer starr_00549 Neighboring gene dystonin Neighboring gene STARR-seq mESC enhancer starr_00551 Neighboring gene predicted gene, 53546 Neighboring gene predicted gene, 23792 Neighboring gene STARR-seq mESC enhancer starr_00553 Neighboring gene STARR-seq mESC enhancer starr_00560 Neighboring gene STARR-seq mESC enhancer starr_00563 Neighboring gene STARR-seq mESC enhancer starr_00567 Neighboring gene microRNA 6896

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Common and distinct DNA-binding and regulatory activities of the BEN-solo transcription factor family. Dai Q, et al. Genes Dev, 2015 Jan 1. PMID 25561495, Free PMC Article
  2. BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells. Dai Q, et al. Development, 2013 May. PMID 23571214, Free PMC Article
  3. Regulation of embryonic and adult neurogenesis by Ars2. Yu Y, et al. Development, 2020 Jan 22. PMID 31969356, Free PMC Article
  4. Transcriptional programs in transient embryonic zones of the cerebral cortex defined by high-resolution mRNA sequencing. Ayoub AE, et al. Proc Natl Acad Sci U S A, 2011 Sep 6. PMID 21873192, Free PMC Article
  5. A CRISPR-based screen for Hedgehog signaling provides insights into ciliary function and ciliopathies. Breslow DK, et al. Nat Genet, 2018 Mar. PMID 29459677, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BEND6 knock down increases neural stem cell self-renewal in neocortex.
    Title: BEND6 is a nuclear antagonist of Notch signaling during self-renewal of neural stem cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription corepressor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of Notch signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within positive regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
BEN domain-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310484.1 → NP_001297413.1  BEN domain-containing protein 6 isoform 2

    See identical proteins and their annotated locations for NP_001297413.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate 5' exon compared to variant 1, which results in translation initiation at a downstream AUG. The resulting isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK044633, BC057378
    Consensus CDS
    CCDS78557.1
    UniProtKB/Swiss-Prot
    Q6PFX2
    Related
    ENSMUSP00000110814.2, ENSMUST00000115161.8
    Conserved Domains (1) summary
    smart01025
    Location:128 → 209
    BEN; The BEN domain is found in diverse animal proteins

  2. NM_177235.3 → NP_796209.2  BEN domain-containing protein 6 isoform 1

    See identical proteins and their annotated locations for NP_796209.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC057378
    Consensus CDS
    CCDS35533.1
    UniProtKB/Swiss-Prot
    Q6PFX2, Q8BLC9, Q8BXN2
    Related
    ENSMUSP00000052919.9, ENSMUST00000062289.11
    Conserved Domains (1) summary
    smart01025
    Location:190 → 271
    BEN; The BEN domain is found in diverse animal proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    33891133..33946925 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321224.3 → XP_017176713.1  BEN domain-containing protein 6 isoform X1

    Conserved Domains (1) summary
    PRK00252
    Location:66 → 102
    alaS; alanyl-tRNA synthetase; Reviewed
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6PFX2.1 GenPept UniProtKB/Swiss-Prot:Q6PFX2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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