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Bend6 BEN domain containing 6 [ Mus musculus (house mouse) ]

Gene ID: 320705, updated on 5-Mar-2024

Summary

Official Symbol
Bend6provided by MGI
Official Full Name
BEN domain containing 6provided by MGI
Primary source
MGI:MGI:2444572
See related
Ensembl:ENSMUSG00000042182 AllianceGenome:MGI:2444572
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
B230209C24Rik
Summary
Enables chromatin binding activity and transcription corepressor activity. Acts upstream of or within negative regulation of Notch signaling pathway and positive regulation of neuron differentiation. Located in nucleus. Is expressed in telencephalon. Orthologous to human BEND6 (BEN domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in cerebellum adult (RPKM 60.3), cortex adult (RPKM 30.9) and 4 other tissues See more
Orthologs
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Genomic context

Location:
1 B; 1 12.85 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (33891133..33946925, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (33852052..33907933, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_00543 Neighboring gene zinc finger protein 451 Neighboring gene predicted gene 15455 Neighboring gene STARR-positive B cell enhancer ABC_E7716 Neighboring gene predicted gene, 38471 Neighboring gene STARR-seq mESC enhancer starr_00549 Neighboring gene dystonin Neighboring gene STARR-seq mESC enhancer starr_00551 Neighboring gene predicted gene, 53546 Neighboring gene predicted gene, 23792 Neighboring gene STARR-seq mESC enhancer starr_00553 Neighboring gene STARR-seq mESC enhancer starr_00560 Neighboring gene STARR-seq mESC enhancer starr_00563 Neighboring gene STARR-seq mESC enhancer starr_00567 Neighboring gene microRNA 6896

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables transcription corepressor activity IGI
Inferred from Genetic Interaction
more info
PubMed 
enables transcription corepressor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
BEN domain-containing protein 6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001310484.1NP_001297413.1  BEN domain-containing protein 6 isoform 2

    See identical proteins and their annotated locations for NP_001297413.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate 5' exon compared to variant 1, which results in translation initiation at a downstream AUG. The resulting isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AK044633, BC057378
    Consensus CDS
    CCDS78557.1
    UniProtKB/Swiss-Prot
    Q6PFX2
    Related
    ENSMUSP00000110814.2, ENSMUST00000115161.8
    Conserved Domains (1) summary
    smart01025
    Location:128209
    BEN; The BEN domain is found in diverse animal proteins
  2. NM_177235.3NP_796209.2  BEN domain-containing protein 6 isoform 1

    See identical proteins and their annotated locations for NP_796209.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC057378
    Consensus CDS
    CCDS35533.1
    UniProtKB/Swiss-Prot
    Q6PFX2, Q8BLC9, Q8BXN2
    Related
    ENSMUSP00000052919.9, ENSMUST00000062289.11
    Conserved Domains (1) summary
    smart01025
    Location:190271
    BEN; The BEN domain is found in diverse animal proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    33891133..33946925 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017321224.3XP_017176713.1  BEN domain-containing protein 6 isoform X1

    Conserved Domains (1) summary
    PRK00252
    Location:66102
    alaS; alanyl-tRNA synthetase; Reviewed