U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Cass4 Cas scaffolding protein family member 4 [ Mus musculus (house mouse) ]

Gene ID: 320664, updated on 11-Apr-2024

Summary

Official Symbol
Cass4provided by MGI
Official Full Name
Cas scaffolding protein family member 4provided by MGI
Primary source
MGI:MGI:2444482
See related
Ensembl:ENSMUSG00000074570 AllianceGenome:MGI:2444482
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
F730031O20Rik
Summary
Predicted to enable protein tyrosine kinase binding activity. Predicted to be involved in several processes, including positive regulation of protein kinase B signaling; positive regulation of protein tyrosine kinase activity; and positive regulation of substrate adhesion-dependent cell spreading. Predicted to act upstream of or within cell adhesion. Predicted to be located in focal adhesion. Predicted to be active in cytoplasm. Predicted to colocalize with plasma membrane. Orthologous to human CASS4 (Cas scaffold protein family member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 2.2), thymus adult (RPKM 1.6) and 20 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
2 H3; 2 94.85 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (172234998..172275672)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (172393644..172433752)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 210, member B Neighboring gene aurora kinase A Neighboring gene cleavage stimulation factor, 3' pre-RNA, subunit 1 Neighboring gene STARR-seq mESC enhancer starr_06572 Neighboring gene STARR-positive B cell enhancer ABC_E823 Neighboring gene uncharacterized LOC118568483 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:172259262-172259485 Neighboring gene STARR-positive B cell enhancer ABC_E3425 Neighboring gene replication termination factor 2 Neighboring gene glucosaminyl (N-acetyl) transferase family member 7 Neighboring gene family with sequence similarity 209

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (5) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • RP23-228E2.3

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in focal adhesion ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 

General protein information

Preferred Names
cas scaffolding protein family member 4
Names
likely orthologue of H. sapiens chromosome 20 open reading frame 32 (C20orf32)

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001080820.4NP_001074289.1  cas scaffolding protein family member 4 isoform 2

    See identical proteins and their annotated locations for NP_001074289.1

    Status: VALIDATED

    Source sequence(s)
    AL833787
    Consensus CDS
    CCDS38347.1
    UniProtKB/Swiss-Prot
    A1L397, Q08EC3, Q08EC4, Q3TCH3
    Related
    ENSMUSP00000104764.3, ENSMUST00000109136.3
    Conserved Domains (3) summary
    cd12000
    Location:1470
    SH3_CASS4; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member 4
    pfam08824
    Location:433588
    Serine_rich; Serine rich protein interaction domain
    cl13463
    Location:683804
    FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
  2. NM_001276422.3NP_001263351.1  cas scaffolding protein family member 4 isoform 3

    See identical proteins and their annotated locations for NP_001263351.1

    Status: VALIDATED

    Source sequence(s)
    AL833787
    Consensus CDS
    CCDS89589.1
    UniProtKB/Swiss-Prot
    Q08EC4
    Related
    ENSMUSP00000154073.2, ENSMUST00000228775.2
    Conserved Domains (3) summary
    cd12000
    Location:1470
    SH3_CASS4; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member 4
    pfam08824
    Location:435590
    Serine_rich; Serine rich protein interaction domain
    cl13463
    Location:659780
    FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
  3. NM_001276423.3NP_001263352.1  cas scaffolding protein family member 4 isoform 4

    See identical proteins and their annotated locations for NP_001263352.1

    Status: VALIDATED

    Source sequence(s)
    AL833787
    Consensus CDS
    CCDS71205.1
    UniProtKB/TrEMBL
    A0A0R4J199
    Related
    ENSMUSP00000099362.3, ENSMUST00000103073.9
    Conserved Domains (3) summary
    cd12000
    Location:1470
    SH3_CASS4; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member 4
    pfam08824
    Location:433588
    Serine_rich; Serine rich protein interaction domain
    cl13463
    Location:657778
    FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
  4. NM_001379465.2NP_001366394.1  cas scaffolding protein family member 4 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AL833787
    Conserved Domains (3) summary
    cd12000
    Location:1470
    SH3_CASS4; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member 4
    pfam08824
    Location:435590
    Serine_rich; Serine rich protein interaction domain
    cl13463
    Location:685806
    FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
  5. NM_001379466.2NP_001366395.1  cas scaffolding protein family member 4 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AL833787
    Conserved Domains (3) summary
    cd12000
    Location:1470
    SH3_CASS4; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member 4
    pfam08824
    Location:435590
    Serine_rich; Serine rich protein interaction domain
    cl13463
    Location:684805
    FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
  6. NM_001379467.2NP_001366396.1  cas scaffolding protein family member 4 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AL833787
    Conserved Domains (3) summary
    cd12000
    Location:1470
    SH3_CASS4; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member 4
    pfam08824
    Location:433588
    Serine_rich; Serine rich protein interaction domain
    cl13463
    Location:682803
    FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    172234998..172275672
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036162308.1XP_036018201.1  cas scaffolding protein family member 4 isoform X1

    Conserved Domains (3) summary
    cd12000
    Location:561
    SH3_CASS4; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member 4
    pfam08824
    Location:426581
    Serine_rich; Serine rich protein interaction domain
    cl13463
    Location:676797
    FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module
  2. XM_036162309.1XP_036018202.1  cas scaffolding protein family member 4 isoform X2

    Conserved Domains (4) summary
    cd12000
    Location:1470
    SH3_CASS4; Src homology 3 domain of CAS (Crk-Associated Substrate) scaffolding protein family member 4
    PHA03378
    Location:60294
    PHA03378; EBNA-3B; Provisional
    pfam08824
    Location:408563
    Serine_rich; Serine rich protein interaction domain
    cl13463
    Location:658779
    FAT-like_CAS_C; C-terminal FAT-like Four helix bundle domain, also called DUF3513, of CAS (Crk-Associated Substrate) scaffolding proteins; a protein interaction module

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001033538.2: Suppressed sequence

    Description
    NM_001033538.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.