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Flad1 flavin adenine dinucleotide synthetase 1 [ Mus musculus (house mouse) ]

Gene ID: 319945, updated on 11-Apr-2024

Summary

Official Symbol
Flad1provided by MGI
Official Full Name
flavin adenine dinucleotide synthetase 1provided by MGI
Primary source
MGI:MGI:2443030
See related
Ensembl:ENSMUSG00000042642 AllianceGenome:MGI:2443030
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pp591; A930017E24Rik
Summary
Predicted to enable FMN adenylyltransferase activity and identical protein binding activity. Predicted to be involved in FAD biosynthetic process. Predicted to be located in cytosol and plasma membrane. Orthologous to human FLAD1 (flavin adenine dinucleotide synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 22.3), testis adult (RPKM 20.4) and 28 other tissues See more
Orthologs
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Genomic context

Location:
3 F1; 3 39.1 cM
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (89309980..89319188, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (89402673..89411881, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 7B Neighboring gene STARR-seq mESC enhancer starr_08237 Neighboring gene STARR-positive B cell enhancer ABC_E3446 Neighboring gene predicted gene 15417 Neighboring gene lens epithelial protein Neighboring gene STARR-positive B cell enhancer ABC_E70 Neighboring gene STARR-seq mESC enhancer starr_08239 Neighboring gene CDC28 protein kinase 1b Neighboring gene src homology 2 domain-containing transforming protein C1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: Lenep

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables FMN adenylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables FMN adenylyltransferase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables FMN adenylyltransferase activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in FAD biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in flavin adenine dinucleotide biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in riboflavin metabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
is_active_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
FAD synthase
Names
FAD pyrophosphorylase
FAD synthetase
FMN adenylyltransferase
RFad1, flavin adenine dinucleotide synthetase, homolog
flavin adenine dinucleotide synthase
NP_001349304.1
NP_001349305.1
NP_796015.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001362375.1NP_001349304.1  FAD synthase

    Status: VALIDATED

    Source sequence(s)
    AC171273
    Consensus CDS
    CCDS38492.1
    UniProtKB/Swiss-Prot
    Q3TSN6, Q8BXQ1, Q8R123
    Related
    ENSMUSP00000103049.2, ENSMUST00000107426.8
    Conserved Domains (2) summary
    cd00885
    Location:17171
    cinA; Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of ...
    cd01713
    Location:303453
    PAPS_reductase; This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly ...
  2. NM_001362376.1NP_001349305.1  FAD synthase

    Status: VALIDATED

    Source sequence(s)
    AC171273
    Consensus CDS
    CCDS38492.1
    UniProtKB/Swiss-Prot
    Q3TSN6, Q8BXQ1, Q8R123
    Conserved Domains (2) summary
    cd00885
    Location:17171
    cinA; Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of ...
    cd01713
    Location:303453
    PAPS_reductase; This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly ...
  3. NM_177041.4NP_796015.2  FAD synthase

    See identical proteins and their annotated locations for NP_796015.2

    Status: VALIDATED

    Source sequence(s)
    BC046769, BY240597
    Consensus CDS
    CCDS38492.1
    UniProtKB/Swiss-Prot
    Q3TSN6, Q8BXQ1, Q8R123
    Related
    ENSMUSP00000122252.3, ENSMUST00000129308.9
    Conserved Domains (2) summary
    cd00885
    Location:17171
    cinA; Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of ...
    cd01713
    Location:303453
    PAPS_reductase; This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly ...

RNA

  1. NR_155545.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC171273

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    89309980..89319188 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)