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TLX2 T cell leukemia homeobox 2 [ Homo sapiens (human) ]

Gene ID: 3196, updated on 21-Dec-2019

Summary

Official Symbol
TLX2provided by HGNC
Official Full Name
T cell leukemia homeobox 2provided by HGNC
Primary source
HGNC:HGNC:5057
See related
Ensembl:ENSG00000115297 MIM:604240
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NCX; HOX11L1
Summary
This gene is a member of an orphan homeobox-containing transcription factor family. Studies of the mouse ortholog have shown that the encoded protein is crucial for the development of the enteric nervous system; in humans, loss-of-function may play a role in tumorigenesis of gastrointestinal stromal tumors. [provided by RefSeq, May 2010]
Expression
Low expression observed in reference dataset See more
Orthologs

Genomic context

See TLX2 in Genome Data Viewer
Location:
2p13.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (74514450..74517148)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (74740686..74744275)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ladybird homeobox 2 Neighboring gene Sharpr-MPRA regulatory region 184 Neighboring gene LBX2 antisense RNA 1 Neighboring gene polycomb group ring finger 1 Neighboring gene DEAQ-box RNA dependent ATPase 1 Neighboring gene AUP1 lipid droplet regulating VLDL assembly factor Neighboring gene HtrA serine peptidase 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
enteric nervous system development IEA
Inferred from Electronic Annotation
more info
 
mesoderm formation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of dendrite morphogenesis IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
cellular_component ND
No biological Data available
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 

General protein information

Preferred Names
T-cell leukemia homeobox protein 2
Names
homeo box 11-like 1
homeobox protein Hox-11L1
neural crest homeobox protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016170.5NP_057254.1  T-cell leukemia homeobox protein 2

    See identical proteins and their annotated locations for NP_057254.1

    Status: REVIEWED

    Source sequence(s)
    AC005041, BC006356, BU740503
    Consensus CDS
    CCDS1947.1
    UniProtKB/Swiss-Prot
    O43763
    Related
    ENSP00000233638.6, ENST00000233638.8
    Conserved Domains (1) summary
    pfam00046
    Location:160213
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    74514450..74517148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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