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TLX1 T cell leukemia homeobox 1 [ Homo sapiens (human) ]

Gene ID: 3195, updated on 4-May-2020

Summary

Official Symbol
TLX1provided by HGNC
Official Full Name
T cell leukemia homeobox 1provided by HGNC
Primary source
HGNC:HGNC:5056
See related
Ensembl:ENSG00000107807 MIM:186770
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TCL3; HOX11
Summary
This gene encodes a nuclear transcription factor that belongs to the NK-linked or NK-like (NKL) subfamily of homeobox genes. The encoded protein is required for normal development of the spleen during embryogenesis. This protein is also involved in specification of neuronal cell fates. Ectopic expression of this gene due to chromosomal translocations is associated with certain T-cell acute lymphoblastic leukemias. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]
Expression
Biased expression in spleen (RPKM 14.4) and salivary gland (RPKM 3.2) See more
Orthologs

Genomic context

See TLX1 in Genome Data Viewer
Location:
10q24.31
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (101130773..101137789)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (102891061..102897546)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984262 Neighboring gene Kazal type serine peptidase inhibitor domain 1 Neighboring gene Sharpr-MPRA regulatory region 9711 Neighboring gene TLX1 neighbor Neighboring gene RNY5 pseudogene 7 Neighboring gene long intergenic non-protein coding RNA 1514 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 pseudogene 7

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC163402

Gene Ontology Provided by GOA

Process Evidence Code Pubs
animal organ development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
T-cell leukemia homeobox protein 1
Names
T-cell leukemia/lymphoma protein 3
homeo box-11 (T-cell leukemia-3 associated breakpoint, homologous to Drosophila Notch)
homeobox protein Hox-11
proto-oncogene TCL-3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_027826.1 RefSeqGene

    Range
    4997..11486
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001195517.2NP_001182446.1  T-cell leukemia homeobox protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001182446.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1. It encodes isoform 2, which has a shorter C-terminus, compared to isoform 1.
    Source sequence(s)
    AL357395, BC130530, BF514683
    Consensus CDS
    CCDS55725.1
    UniProtKB/Swiss-Prot
    P31314
    Related
    ENSP00000434914.2, ENST00000467928.2
    Conserved Domains (1) summary
    pfam00046
    Location:204257
    Homeobox; Homeobox domain
  2. NM_005521.4NP_005512.1  T-cell leukemia homeobox protein 1 isoform 1

    See identical proteins and their annotated locations for NP_005512.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL357395, BC130530, BF514683, M62626, S38742
    Consensus CDS
    CCDS7510.1
    UniProtKB/Swiss-Prot
    P31314
    Related
    ENSP00000359215.6, ENST00000370196.11
    Conserved Domains (1) summary
    pfam00046
    Location:204257
    Homeobox; Homeobox domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    101130773..101137789
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539745.3XP_011538047.1  T-cell leukemia homeobox protein 1 isoform X2

    Conserved Domains (1) summary
    pfam00046
    Location:216269
    Homeobox; Homeobox domain
  2. XM_011539744.3XP_011538046.1  T-cell leukemia homeobox protein 1 isoform X1

    Conserved Domains (1) summary
    pfam00046
    Location:216269
    Homeobox; Homeobox domain
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