H4c12 H4 clustered histone 12 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: H4c12provided by MGI
Official Full Name: H4 clustered histone 12provided by MGI
Primary source: MGI:MGI:2448439
See related: Ensembl:ENSMUSG00000064288 AllianceGenome:MGI:2448439
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: H4c1; H4c2; H4c3; H4c4; H4c6; H4c8; H4c9; H4c11; H4c14; H4c16; H4f16; Hist1h4k
Summary: Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H4 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. [provided by RefSeq, Aug 2015]
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Genomic context

Location:: 13; 13 A3.1

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
109	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (21934315..21934723, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (21750145..21750553, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hist1h4j (e-PCR), detects polymorphism
- UniSTS:545857

NoName (e-PCR)
- UniSTS:487784

NoName (e-PCR)
- UniSTS:491902

NoName (e-PCR)
- UniSTS:493002

Homology

Homologs of the H4c12 gene: The H4c12 gene is conserved in human, chimpanzee, cow, rat, zebrafish, fruit fly, mosquito, C.elegans, A.thaliana, rice, and frog.
Orthologs

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural constituent of chromatin	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of CENP-A containing nucleosome	ISO Inferred from Sequence Orthology more info
part_of nucleosome	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: histone H4

Names: histone 1, H4k; histone cluster 1, H4k

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.