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APOF apolipoprotein F [ Homo sapiens (human) ]

Gene ID: 319, updated on 5-Jul-2025
Official Symbol
APOFprovided by HGNC
Official Full Name
apolipoprotein Fprovided by HGNC
Primary source
HGNC:HGNC:615
See related
Ensembl:ENSG00000175336 MIM:107760; AllianceGenome:HGNC:615
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LTIP; Apo-F
Summary
The product of this gene is one of the minor apolipoproteins found in plasma. This protein forms complexes with lipoproteins and may be involved in transport and/or esterification of cholesterol. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward liver (RPKM 110.1) See more
Orthologs
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See APOF in Genome Data Viewer
Location:
12q13.3
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (56360568..56362857, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (56328255..56330544, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56754352..56756641, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr12:56731981-56733180 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_29688 Neighboring gene interleukin 23 subunit alpha Neighboring gene signal transducer and activator of transcription 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4558 Neighboring gene RNA, U7 small nuclear 40 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6493 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6494 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6495 Neighboring gene TBCC domain containing 1 pseudogene Neighboring gene apolipoprotein N, pseudogene

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EBI GWAS Catalog

Description
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
EBI GWAS Catalog
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • MGC22520, DKFZp781G18150

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cholesterol binding TAS
Traceable Author Statement
more info
PubMed 
enables lipid transporter activity TAS
Traceable Author Statement
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cholesterol efflux IEA
Inferred from Electronic Annotation
more info
 
involved_in cholesterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cholesterol metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid transport TAS
Traceable Author Statement
more info
PubMed 
involved_in steroid metabolic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within triglyceride metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
part_of high-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 
part_of low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
apolipoprotein F
Names
lipid transfer inhibitor protein

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001638.4NP_001629.1  apolipoprotein F preproprotein

    See identical proteins and their annotated locations for NP_001629.1

    Status: REVIEWED

    Source sequence(s)
    AC025574
    Consensus CDS
    CCDS44923.1
    UniProtKB/Swiss-Prot
    Q13790, Q8TC13
    UniProtKB/TrEMBL
    B2RC09
    Related
    ENSP00000381250.3, ENST00000398189.4
    Conserved Domains (1) summary
    pfam15148
    Location:63260
    Apolipo_F; Apolipoprotein F

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    56360568..56362857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    56328255..56330544 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)