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APOF apolipoprotein F [ Homo sapiens (human) ]

Gene ID: 319, updated on 4-May-2020

Summary

Official Symbol
APOFprovided by HGNC
Official Full Name
apolipoprotein Fprovided by HGNC
Primary source
HGNC:HGNC:615
See related
Ensembl:ENSG00000175336 MIM:107760
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LTIP; Apo-F
Summary
The product of this gene is one of the minor apolipoproteins found in plasma. This protein forms complexes with lipoproteins and may be involved in transport and/or esterification of cholesterol. [provided by RefSeq, Jul 2008]
Expression
Restricted expression toward liver (RPKM 110.1) See more
Orthologs

Genomic context

See APOF in Genome Data Viewer
Location:
12q13.3
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (56360568..56362857, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (56754355..56756583, complement)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene interleukin 23 subunit alpha Neighboring gene signal transducer and activator of transcription 2 Neighboring gene RNA, U7 small nuclear 40 pseudogene Neighboring gene TBCC domain containing 1 pseudogene Neighboring gene apolipoprotein N, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC22520, DKFZp781G18150

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cholesterol binding TAS
Traceable Author Statement
more info
PubMed 
lipid transporter activity TAS
Traceable Author Statement
more info
PubMed 
signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cholesterol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol metabolic process IEA
Inferred from Electronic Annotation
more info
 
lipid metabolic process TAS
Traceable Author Statement
more info
PubMed 
lipid transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
high-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 
low-density lipoprotein particle IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
apolipoprotein F
Names
lipid transfer inhibitor protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001638.4NP_001629.1  apolipoprotein F preproprotein

    See identical proteins and their annotated locations for NP_001629.1

    Status: REVIEWED

    Source sequence(s)
    AC025574
    Consensus CDS
    CCDS44923.1
    UniProtKB/Swiss-Prot
    Q13790
    Related
    ENSP00000381250.3, ENST00000398189.4
    Conserved Domains (1) summary
    pfam15148
    Location:63260
    Apolipo_F; Apolipoprotein F

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    56360568..56362857 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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