U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

APC4 Anaphase Promoting Complex subunit 4 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31835, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
APC4provided by FlyBase
Official Full Name
Anaphase Promoting Complex subunit 4provided by FlyBase
Primary source
FLYBASE:FBgn0052707
Locus tag
Dmel_CG32707
See related
AllianceGenome:FB:FBgn0052707
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG32707; CG4350; Dmel\CG32707
Summary
Involved in protein catabolic process. Predicted to be part of anaphase-promoting complex. Predicted to be active in nuclear periphery. Is expressed in organism. Orthologous to human ANAPC4 (anaphase promoting complex subunit 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
8C4-8C7; 1-26 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (9082931..9085867)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8976964..8979900)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Heterochromatin Protein 1b Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. HP1B is a euchromatic Drosophila HP1 homolog with links to metabolism. Mills BB, et al. PLoS One, 2018. PMID 30346969, Free PMC Article
  2. PP1-mediated moesin dephosphorylation couples polar relaxation to mitotic exit. Kunda P, et al. Curr Biol, 2012 Feb 7. PMID 22209527
  3. The conserved discs-large binding partner Banderuola regulates asymmetric cell division in Drosophila. Mauri F, et al. Curr Biol, 2014 Aug 18. PMID 25088559
  4. Transcription-independent function of Polycomb group protein PSC in cell cycle control. Mohd-Sarip A, et al. Science, 2012 May 11. PMID 22491092
  5. The anaphase-promoting complex: it's not just for mitosis any more. Harper JW, et al. Genes Dev, 2002 Sep 1. PMID 12208841

See all (39) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in anaphase-promoting complex-dependent catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anaphase-promoting complex-dependent catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in anaphase-promoting complex-dependent catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K11-linked ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of mitotic metaphase/anaphase transition IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of anaphase-promoting complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of anaphase-promoting complex IEA
Inferred from Electronic Annotation
more info
  
part_of anaphase-promoting complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in nuclear periphery IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
anaphase promoting complex subunit 4
Names
APC4-PA
APC4-PC
CG32707-PA
CG32707-PC
anaphase promoting complex 4

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    9082931..9085867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_132294.3 → NP_572522.2  anaphase promoting complex subunit 4, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_572522.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95R47, Q9W395
    Related
    FBpp0071222
    Conserved Domains (3) summary
    pfam12894
    Location:6 → 52
    ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
    pfam12896
    Location:222 → 418
    ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4
    sd00039
    Location:20 → 54
    7WD40; WD40 repeat [structural motif]

  2. NM_001169243.3 → NP_001162714.2  anaphase promoting complex subunit 4, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001162714.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JJG4, Q95R47
    Conserved Domains (3) summary
    pfam12894
    Location:6 → 52
    ANAPC4_WD40; Anaphase-promoting complex subunit 4 WD40 domain
    pfam12896
    Location:222 → 416
    ANAPC4; Anaphase-promoting complex, cyclosome, subunit 4
    sd00039
    Location:20 → 54
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JJG4 E1JJG4
Q95R47 Q95R47
Q9W395 Q9W395

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials
Tools
Miscellaneous