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CG32751 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 318189, updated on 18-Sep-2024

Summary

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Official Symbol
CG32751provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0052751
Locus tag
Dmel_CG32751
See related
AllianceGenome:FB:FBgn0052751
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3648; Dmel\CG32751
Summary
Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides. Predicted to be involved in nitrogen compound metabolic process. Human ortholog(s) of this gene implicated in biotinidase deficiency. Orthologous to several human genes including BTD (biotinidase); VNN1 (vanin 1); and VNN2 (vanin 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
5D8-5D8; 1-15 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (6196580..6198654, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (6090613..6092687, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene Ca[2+]-channel protein alpha[[1]] subunit T Neighboring gene uncharacterized protein Neighboring gene vanin-like Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Developmental ethanol exposure leads to dysregulation of lipid metabolism and oxidative stress in Drosophila. Logan-Garbisch T, et al. G3 (Bethesda), 2014 Nov 11. PMID 25387828, Free PMC Article
  2. Unanchored ubiquitin chains do not lead to marked alterations in gene expression in Drosophila melanogaster. Blount JR, et al. Biol Open, 2019 May 30. PMID 31097444, Free PMC Article
  3. dGLYAT modulates Gadd45-mediated JNK activation and cell invasion. Xu M, et al. Cell Div, 2022 Aug 6. PMID 35933447, Free PMC Article
  4. Microbiota-induced changes in drosophila melanogaster host gene expression and gut morphology. Broderick NA, et al. mBio, 2014 May 27. PMID 24865556, Free PMC Article
  5. Genes conserved in bilaterians but jointly lost with Myc during nematode evolution are enriched in cell proliferation and cell migration functions. Erives AJ. Dev Genes Evol, 2015 Sep. PMID 26173873, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
Inferred from Electronic Annotation
more info
  
enables pantetheine hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG32751-PA
CG32751-PB
pantetheine hydrolase
NP_001284927.1
NP_727068.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    6196580..6198654 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001297998.1 → NP_001284927.1  uncharacterized protein Dmel_CG32751, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001284927.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D5SHR9, Q8IRR1, X2JDW2
    UniProtKB/TrEMBL
    C0PPJ7
    Conserved Domains (2) summary
    cd07567
    Location:33 → 329
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
    pfam19018
    Location:324 → 503
    Vanin_C; Vanin C-terminal domain

  2. NM_167061.3 → NP_727068.1  uncharacterized protein Dmel_CG32751, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_727068.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C0PPJ7
    Related
    FBpp0070845
    Conserved Domains (1) summary
    cd07567
    Location:33 → 321
    biotinidase_like; biotinidase and vanins (class 4 nitrilases)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8IRR1.2 Q8IRR1

Gene LinkOut

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