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DHRS4L2 dehydrogenase/reductase 4 like 2 [ Homo sapiens (human) ]

Gene ID: 317749, updated on 25-Nov-2021

Summary

Official Symbol
DHRS4L2provided by HGNC
Official Full Name
dehydrogenase/reductase 4 like 2provided by HGNC
Primary source
HGNC:HGNC:19731
See related
Ensembl:ENSG00000187630 MIM:615196
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDR25C3
Summary
This gene encodes a member of the short chain dehydrogenase reductase family. The encoded protein may be an NADPH dependent retinol oxidoreductase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
Expression
Broad expression in kidney (RPKM 43.2), small intestine (RPKM 16.8) and 24 other tissues See more
Orthologs
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Genomic context

See DHRS4L2 in Genome Data Viewer
Location:
14q11.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (23969874..24006408)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24439083..24475617)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 596 Neighboring gene uncharacterized LOC105370411 Neighboring gene DHRS4 antisense RNA 1 Neighboring gene dehydrogenase/reductase 4 Neighboring gene dehydrogenase/reductase 4 like 1 Neighboring gene uncharacterized LOC105370412 Neighboring gene capping protein regulator and myosin 1 linker 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC905, FLJ11525

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbonyl reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in retinal metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dehydrogenase/reductase SDR family member 4-like 2
Names
NADPH-dependent retinol dehydrogenase/reductase-like protein 2
dehydrogenase/reductase (SDR family) member 4 like 2
dehydrogenase/reductase (SDR family) member 4 like 2A3
short chain dehydrogenase/reductase family 25C member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023545.1 RefSeqGene

    Range
    5001..41535
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001193635.1NP_001180564.1  dehydrogenase/reductase SDR family member 4-like 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AL136419, DN237882, GU564234
    UniProtKB/TrEMBL
    D5KJA1
    Conserved Domains (2) summary
    pfam13900
    Location:215
    GVQW; Putative domain of unknown function
    cl21454
    Location:16148
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_001193636.1NP_001180565.1  dehydrogenase/reductase SDR family member 4-like 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL136419, DA738374, DQ088987, GU564234, GU564235
    Consensus CDS
    CCDS86376.1
    UniProtKB/TrEMBL
    D5KJA1, D5KJA2
    Related
    ENSP00000441433.3, ENST00000543805.6
    Conserved Domains (1) summary
    cl21454
    Location:1109
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. NM_001193637.1NP_001180566.1  dehydrogenase/reductase SDR family member 4-like 2 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (4) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AL136419, DA738374, DN237881, GU564234
    Consensus CDS
    CCDS73621.1
    UniProtKB/TrEMBL
    D5KJA1, F6VUV4
    Related
    ENSP00000441095.2, ENST00000534993.5
    Conserved Domains (1) summary
    cl21454
    Location:168
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. NM_198083.4NP_932349.2  dehydrogenase/reductase SDR family member 4-like 2 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL136419, BC101814, GU564234
    Consensus CDS
    CCDS9606.2
    UniProtKB/TrEMBL
    D5KJA1
    Related
    ENSP00000334801.6, ENST00000335125.11
    Conserved Domains (2) summary
    pfam00106
    Location:33210
    adh_short; short chain dehydrogenase
    cl21454
    Location:24210
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    23969874..24006408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p13 PATCHES

    Range
    270855..312739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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