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DHRS4L2 dehydrogenase/reductase 4 like 2 [ Homo sapiens (human) ]

Gene ID: 317749, updated on 1-Oct-2022

Summary

Official Symbol
DHRS4L2provided by HGNC
Official Full Name
dehydrogenase/reductase 4 like 2provided by HGNC
Primary source
HGNC:HGNC:19731
See related
Ensembl:ENSG00000187630 MIM:615196; AllianceGenome:HGNC:19731
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDR25C3
Summary
This gene encodes a member of the short chain dehydrogenase reductase family. The encoded protein may be an NADPH dependent retinol oxidoreductase. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]
Expression
Broad expression in kidney (RPKM 43.2), small intestine (RPKM 16.8) and 24 other tissues See more
Orthologs
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Genomic context

See DHRS4L2 in Genome Data Viewer
Location:
14q11.2
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (23969874..24006408)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (18170210..18210077)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (24439083..24475617)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene DHRS4 antisense RNA 1 Neighboring gene uncharacterized LOC124903290 Neighboring gene dehydrogenase/reductase 4 Neighboring gene dehydrogenase/reductase 4 like 1 (pseudogene) Neighboring gene capping protein regulator and myosin 1 linker 3 Neighboring gene uncharacterized LOC105370412

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC905, FLJ11525

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbonyl reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in retinal metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
is_active_in peroxisome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
dehydrogenase/reductase SDR family member 4-like 2
Names
NADPH-dependent retinol dehydrogenase/reductase-like protein 2
dehydrogenase/reductase (SDR family) member 4 like 2
dehydrogenase/reductase (SDR family) member 4 like 2A3
short chain dehydrogenase/reductase family 25C member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023545.1 RefSeqGene

    Range
    24056..41530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001193635.1NP_001180564.1  dehydrogenase/reductase SDR family member 4-like 2 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2, coding) represents the allele encoded by the GRCh38 reference genome and encodes isoform 2.
    Source sequence(s)
    AL136419, DN237882, GU564234
    UniProtKB/TrEMBL
    D5KJA1
    Conserved Domains (2) summary
    pfam13900
    Location:215
    GVQW; Putative domain of unknown function
    cl21454
    Location:16148
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  2. NM_001193636.1NP_001180565.1  dehydrogenase/reductase SDR family member 4-like 2 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3, coding) represents the allele encoded by the GRCh38 reference genome and encodes isoform 3.
    Source sequence(s)
    AL136419, DA738374, DQ088987, GU564234, GU564235
    Consensus CDS
    CCDS86376.1
    UniProtKB/TrEMBL
    A0A087WSZ6, D5KJA1, D5KJA2
    Related
    ENSP00000441433.3, ENST00000543805.6
    Conserved Domains (1) summary
    cl21454
    Location:1109
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  3. NM_001193637.1NP_001180566.1  dehydrogenase/reductase SDR family member 4-like 2 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AL136419, DA738374, DN237881, GU564234
    Consensus CDS
    CCDS73621.1
    UniProtKB/TrEMBL
    D5KJA1, F6VUV4
    Related
    ENSP00000441095.2, ENST00000534993.5
    Conserved Domains (1) summary
    cl21454
    Location:168
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
  4. NM_001412315.1NP_001399244.1  dehydrogenase/reductase SDR family member 4-like 2 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses the same exon combination as variant 4 but represents the allele encoded by the T2T-CHM13v2.0 genome assembly. The encoded isoform (5) has a frameshifted C-terminus compared to isoform 4.
    Source sequence(s)
    CP068264
  5. NM_198083.4NP_932349.2  dehydrogenase/reductase SDR family member 4-like 2 isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1, coding) represents the allele encoded by the GRCh38 reference genome and encodes isoform 1.
    Source sequence(s)
    AL136419, BC101814, GU564234
    Consensus CDS
    CCDS9606.2
    UniProtKB/Swiss-Prot
    Q3YLD4
    UniProtKB/TrEMBL
    D5KJA1
    Related
    ENSP00000334801.6, ENST00000335125.11
    Conserved Domains (1) summary
    cl21454
    Location:24210
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. NR_178184.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: Transcript Variant: This variant (1, non-coding) uses the same exon combination as variant (1, coding) but represents the allele present on the T2T-CHM13v2.0 genome assembly. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    CP068264
  2. NR_178185.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: Transcript Variant: This variant (2, non-coding) uses the same exon combination as variant (2, coding) but represents the allele present on the T2T-CHM13v2.0 genome assembly. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    CP068264
  3. NR_178186.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: Transcript Variant: This variant (3, non-coding) uses the same exon combination as variant (3, coding) but represents the allele present on the T2T-CHM13v2.0 genome assembly. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    CP068264

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    23969874..24006408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_018654722.1 Reference GRCh38.p14 PATCHES

    Range
    270855..312739
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    18170210..18210077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)