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CATHL6 cathelicidin 6 [ Bos taurus (domestic cattle) ]

Gene ID: 317651, updated on 10-Aug-2024

Summary

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Gene symbol
CATHL6
Gene description
cathelicidin 6
See related
BGD:BT10698; Ensembl:ENSBTAG00000066471
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Bos taurus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
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Genomic context

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Location:
chromosome: 22
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_09 current ARS-UCD2.0 (GCF_002263795.3) 22 NC_037349.1 (51663351..51665275, complement)

Chromosome 22 - NC_037349.1Genomic Context describing neighboring genes Neighboring gene cathelicidin 2 Neighboring gene cathelicidin-4 Neighboring gene cathelicidin 5 Neighboring gene cell division cycle 25A

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_037349.1 Chromosome 22 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Brief Note :Variability in the cathelicidin 6 (CATHL-6) gene in Tianzhu white yak from Tibetan area in China. E GX, et al. Genet Mol Res, 2015 Apr 10. PMID 25966077
  2. Design of nontoxic analogues of cathelicidin-derived bovine antimicrobial peptide BMAP-27: the role of leucine as well as phenylalanine zipper sequences in determining its toxicity. Ahmad A, et al. Biochemistry, 2009 Nov 24. PMID 19845398
  3. Biological characterization of two novel cathelicidin-derived peptides and identification of structural requirements for their antimicrobial and cell lytic activities. Skerlavaj B, et al. J Biol Chem, 1996 Nov 8. PMID 8910461
  4. Sequence analysis and polymorphism discovery in 4 members of the bovine cathelicidin gene family. Gillenwaters EN, et al. J Hered, 2009 Mar-Apr. PMID 19136450
  5. A whole-genome assembly of the domestic cow, Bos taurus. Zimin AV, et al. Genome Biol, 2009. PMID 19393038, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that the total length of the aligned Yak cathelicidin 6 (CATHL-6) sequences was 1923 bp, including six single nucleotide polymorphisms and one indel.
    Title: Brief Note :Variability in the cathelicidin 6 (CATHL-6) gene in Tianzhu white yak from Tibetan area in China.
  2. Not only a leucine zipper but also a phenylalanine zipper sequence plays an important role in maintaining the assembly of BMAP-27 on mammalian cells and the cytotoxic activity against them.
    Title: Design of nontoxic analogues of cathelicidin-derived bovine antimicrobial peptide BMAP-27: the role of leucine as well as phenylalanine zipper sequences in determining its toxicity.
  3. Characterization of single nucleotide polymorphisms (SNPs) and insertion-deletion (indel) polymorphisms within the bovine CATHL gene family.
    Title: Sequence analysis and polymorphism discovery in 4 members of the bovine cathelicidin gene family.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables lipopolysaccharide binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cathelicidin-6
Names
antibacterial peptide BMAP-27
antimicrobial peptide BMAP-27
myeloid antibacterial peptide 27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_174832.3 → NP_777257.1  cathelicidin-6 precursor

    See identical proteins and their annotated locations for NP_777257.1

    Status: PROVISIONAL

    Source sequence(s)
    X97608
    UniProtKB/Swiss-Prot
    B9UKM5, P54228
    UniProtKB/TrEMBL
    B9UKM7
    Related
    ENSBTAP00000062320.2, ENSBTAT00000079324.2
    Conserved Domains (1) summary
    pfam00666
    Location:31 → 98
    Cathelicidins; Cathelicidin

RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2023_09

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UCD2.0 Primary Assembly

Genomic

  1. NC_037349.1 Reference ARS-UCD2.0 Primary Assembly

    Range
    51663351..51665275 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54228.1 GenPept UniProtKB/Swiss-Prot:P54228

Gene LinkOut

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Molecular Biology Databases
Research Materials