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HNF4G hepatocyte nuclear factor 4 gamma [ Homo sapiens (human) ]

Gene ID: 3174, updated on 1-Aug-2020

Summary

Official Symbol
HNF4Gprovided by HGNC
Official Full Name
hepatocyte nuclear factor 4 gammaprovided by HGNC
Primary source
HGNC:HGNC:5026
See related
Ensembl:ENSG00000164749 MIM:605966
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NR2A2; NR2A3
Expression
Biased expression in small intestine (RPKM 55.0), duodenum (RPKM 46.4) and 5 other tissues See more
Orthologs

Genomic context

See HNF4G in Genome Data Viewer
Location:
8q21.13
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (75407567..75566834)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (76452203..76479069)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene HIG1 hypoxia inducible domain family member 1A pseudogene 6 Neighboring gene pyruvate kinase M1/2 pseudogene 4 Neighboring gene uncharacterized LOC105375906 Neighboring gene VISTA enhancer hs891 Neighboring gene uncharacterized LOC102724858 Neighboring gene RNA, U2 small nuclear 54, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
NHGRI GWA Catalog
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
NHGRI GWA Catalog
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
anatomical structure development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription initiation from RNA polymerase II promoter TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
centrosome IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
hepatocyte nuclear factor 4-gamma
Names
HNF-4-gamma
nuclear receptor subfamily 2 group A member 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330561.2NP_001317490.1  hepatocyte nuclear factor 4-gamma isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC021500, AC040917, AC105218
    Consensus CDS
    CCDS83303.1
    UniProtKB/Swiss-Prot
    Q14541
    Conserved Domains (2) summary
    cd06931
    Location:103324
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:1287
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
  2. NM_004133.5NP_004124.5  hepatocyte nuclear factor 4-gamma isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC040917, BX571750
    Consensus CDS
    CCDS6220.2
    Related
    ENSP00000379701.3, ENST00000396423.4

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    75407567..75566834
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017013373.1XP_016868862.1  hepatocyte nuclear factor 4-gamma isoform X1

    UniProtKB/Swiss-Prot
    Q14541
    Conserved Domains (2) summary
    cd06931
    Location:103324
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:1287
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
  2. XM_017013374.1XP_016868863.1  hepatocyte nuclear factor 4-gamma isoform X1

    UniProtKB/Swiss-Prot
    Q14541
    Conserved Domains (2) summary
    cd06931
    Location:103324
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:1287
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
  3. XM_017013375.1XP_016868864.1  hepatocyte nuclear factor 4-gamma isoform X1

    UniProtKB/Swiss-Prot
    Q14541
    Related
    ENSP00000346339.1, ENST00000354370.5
    Conserved Domains (2) summary
    cd06931
    Location:103324
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:1287
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
  4. XM_017013376.2XP_016868865.1  hepatocyte nuclear factor 4-gamma isoform X1

    UniProtKB/Swiss-Prot
    Q14541
    Conserved Domains (2) summary
    cd06931
    Location:103324
    NR_LBD_HNF4_like; The ligand binding domain of heptocyte nuclear factor 4, which is explosively expanded in nematodes
    cd06960
    Location:1287
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
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