U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mutL DNA mismatch repair endonuclease MutL [ Thermus thermophilus HB8 ]

Gene ID: 3169099, updated on 12-Feb-2024

Summary

Go to the top of the page Help
Gene symbol
mutL
Gene description
DNA mismatch repair endonuclease MutL
Locus tag
TTH_RS06700
Gene type
protein coding
Organism
Thermus thermophilus HB8 (strain: HB8, type-material: type strain of Thermus thermophilus)
Lineage
Bacteria; Deinococcota; Deinococci; Thermales; Thermaceae; Thermus
Old locus tag
TTHA1323
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
chromosome: 1
Sequence:
Chromosome: 1; NC_006461.1 (1260152..1261789, complement)

Chromosome 1 - NC_006461.1Genomic Context describing neighboring genes Neighboring gene trypsin-like peptidase domain-containing protein Neighboring gene formyltetrahydrofolate deformylase Neighboring gene ribonuclease E activity regulator RraA Neighboring gene DNA mismatch repair protein MutS Neighboring gene sulfite oxidase Neighboring gene c-type cytochrome Neighboring gene MOSC domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_006461.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Bound nucleotide controls the endonuclease activity of mismatch repair enzyme MutL. Fukui K, et al. J Biol Chem, 2008 May 2. PMID 18310077
  2. MutS stimulates the endonuclease activity of MutL in an ATP-hydrolysis-dependent manner. Shimada A, et al. FEBS J, 2013 Jul. PMID 23679952
  3. Inactivation of the DNA repair genes mutS, mutL or the anti-recombination gene mutS2 leads to activation of vitamin B1 biosynthesis genes. Fukui K, et al. PLoS One, 2011 Apr 28. PMID 21552516, Free PMC Article
  4. MutL traps MutS at a DNA mismatch. Qiu R, et al. Proc Natl Acad Sci U S A, 2015 Sep 1. PMID 26283381, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ATP hydrolysis by MutS and MutL is involved in the mismatch-dependent activation of MutL endonuclease activity.
    Title: MutS stimulates the endonuclease activity of MutL in an ATP-hydrolysis-dependent manner.
  2. disruption of DNA repair genes mutS and mutL, or the anti-recombination gene mutS2, in Thermus thermophilus HB8, induces the biosynthesis pathway for vitamin B(1)
    Title: Inactivation of the DNA repair genes mutS, mutL or the anti-recombination gene mutS2 leads to activation of vitamin B1 biosynthesis genes.
  3. The endonuclease activity of ttMutL and its regulation by ATP binding are necessary for DNA repair in vivo.
    Title: Bound nucleotide controls the endonuclease activity of mismatch repair enzyme MutL.
Submit: New GeneRIF Correction

General protein information

Go to the top of the page Help
Preferred Names
DNA mismatch repair endonuclease MutL

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_006461.1 Reference assembly

    Range
    1260152..1261789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_011228596.1 MULTISPECIES: DNA mismatch repair endonuclease MutL [Thermus]

    See identical proteins and their annotated locations for WP_011228596.1

    UniProtKB/Swiss-Prot
    Q5SIP6, Q9RA54
    Conserved Domains (1) summary
    COG0323
    Location:2 → 511
    MutL; DNA mismatch repair ATPase MutL [Replication, recombination and repair]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9RA54.2