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HMMR hyaluronan mediated motility receptor [ Homo sapiens (human) ]

Gene ID: 3161, updated on 1-Jun-2020

Summary

Official Symbol
HMMRprovided by HGNC
Official Full Name
hyaluronan mediated motility receptorprovided by HGNC
Primary source
HGNC:HGNC:5012
See related
Ensembl:ENSG00000072571 MIM:600936
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CD168; IHABP; RHAMM
Summary
The protein encoded by this gene is involved in cell motility. It is expressed in breast tissue and together with other proteins, it forms a complex with BRCA1 and BRCA2, thus is potentially associated with higher risk of breast cancer. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Dec 2008]
Expression
Biased expression in testis (RPKM 12.7), lymph node (RPKM 9.0) and 11 other tissues See more
Orthologs

Genomic context

See HMMR in Genome Data Viewer
Location:
5q34
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (163460632..163491941)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (162887517..162918951)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377700 Neighboring gene cyclin G1 Neighboring gene NudC domain containing 2 Neighboring gene HMMR antisense RNA 1 Neighboring gene methionine adenosyltransferase 2B Neighboring gene uncharacterized LOC102724458

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC119494, MGC119495

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hyaluronic acid binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
hyaluronan catabolic process TAS
Traceable Author Statement
more info
 
regulation of G2/M transition of mitotic cell cycle TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cell surface IEA
Inferred from Electronic Annotation
more info
 
centrosome IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
membrane HDA PubMed 
microtubule cytoskeleton IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
hyaluronan mediated motility receptor
Names
intracellular hyaluronic acid-binding protein
receptor for hyaluronan-mediated motility

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023309.1 RefSeqGene

    Range
    5122..36431
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001142556.2NP_001136028.1  hyaluronan mediated motility receptor isoform a

    See identical proteins and their annotated locations for NP_001136028.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a).
    Source sequence(s)
    AW629232, AY623426, DB091289
    Consensus CDS
    CCDS47334.1
    UniProtKB/Swiss-Prot
    O75330
    Related
    ENSP00000377492.4, ENST00000393915.9
    Conserved Domains (3) summary
    pfam01496
    Location:77145
    V_ATPase_I; V-type ATPase 116kDa subunit family
    pfam15905
    Location:16339
    HMMR_N; Hyaluronan mediated motility receptor N-terminal
    pfam15908
    Location:553709
    HMMR_C; Hyaluronan mediated motility receptor C-terminal
  2. NM_001142557.2NP_001136029.1  hyaluronan mediated motility receptor isoform d

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) is missing 3 consecutive internal coding exons compared to transcript variant 1. This results in translation initiation from an alternate AUG start site and a shorter isoform (d) with an unique N-terminus compared to isoform a.
    Source sequence(s)
    AW629232, AY623426, DB091289
    Consensus CDS
    CCDS47335.1
    UniProtKB/Swiss-Prot
    O75330
    Related
    ENSP00000402673.2, ENST00000432118.6
    Conserved Domains (3) summary
    pfam01496
    Location:1458
    V_ATPase_I; V-type ATPase 116kDa subunit family
    pfam15905
    Location:5252
    HMMR_N; Hyaluronan mediated motility receptor N-terminal
    pfam15908
    Location:466622
    HMMR_C; Hyaluronan mediated motility receptor C-terminal
  3. NM_012484.3NP_036616.2  hyaluronan mediated motility receptor isoform b

    See identical proteins and their annotated locations for NP_036616.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate acceptor splice site at one of the coding exons compared to transcript variant 1, resulting in an isoform (b) that is 1 aa shorter than isoform a.
    Source sequence(s)
    AF032862, AW629232, AY623426, DB091289
    Consensus CDS
    CCDS4362.1
    UniProtKB/Swiss-Prot
    O75330
    Related
    ENSP00000351554.3, ENST00000358715.3
    Conserved Domains (3) summary
    pfam01496
    Location:76144
    V_ATPase_I; V-type ATPase 116kDa subunit family
    pfam15905
    Location:16338
    HMMR_N; Hyaluronan mediated motility receptor N-terminal
    pfam15908
    Location:552708
    HMMR_C; Hyaluronan mediated motility receptor C-terminal
  4. NM_012485.3NP_036617.2  hyaluronan mediated motility receptor isoform c

    See identical proteins and their annotated locations for NP_036617.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is missing an in-frame coding exon compared to transcript variant 1, resulting in an isoform (c) which lacks an internal 16 aa segment compared to isoform a.
    Source sequence(s)
    AW629232, AY623426, DB091289
    Consensus CDS
    CCDS4363.1
    UniProtKB/Swiss-Prot
    O75330
    Related
    ENSP00000185942.6, ENST00000353866.7
    Conserved Domains (3) summary
    pfam01496
    Location:85129
    V_ATPase_I; V-type ATPase 116kDa subunit family
    pfam15905
    Location:16323
    HMMR_N; Hyaluronan mediated motility receptor N-terminal
    pfam15908
    Location:537693
    HMMR_C; Hyaluronan mediated motility receptor C-terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    163460632..163491941
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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