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N Notch [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31293, updated on 26-Aug-2021

Summary

Official Symbol
Nprovided by FlyBase
Official Full Name
Notchprovided by FlyBase
Primary source
FLYBASE:FBgn0004647
Locus tag
Dmel_CG3936
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1.1; 16-178; 16-55; anon-EST:Liang-1.12; Ax; CG3936; Chp; clone 1.12; co; Co; CT13012; Dmel\CG3936; dNotch; EG:140G11.1; EG:163A10.2; fa; l(1)3Cb; l(1)Ax; l(1)N; nd; NECD; Nicd; NICD; notch; n[fah]; RICN; shd; spl; swb
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Genomic context

Location:
3C7-3C9; 1-2 cM
Exon count:
9
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (3134870..3172221)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (3028903..3066254)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene kin of irre Neighboring gene roughest Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Follicle cell protein 3C

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables WW domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
enables chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables histone acetyltransferase binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane signaling receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in Malpighian tubule tip cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in Notch signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in Notch signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in R1/R6 cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in R3/R4 cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in R7 cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
NOT involved_in anesthesia-resistant memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in asymmetric cell division TAS
Traceable Author Statement
more info
PubMed 
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in border follicle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell dedifferentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cell fate commitment IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chaeta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chaeta morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in compartment boundary maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in compound eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in compound eye retinal cell programmed cell death TAS
Traceable Author Statement
more info
PubMed 
involved_in crystal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal appendage formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dorsal closure TAS
Traceable Author Statement
more info
PubMed 
involved_in dorsal/ventral axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial cell proliferation involved in Malpighian tubule morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial cell type specification, open tracheal system IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in eye-antennal disc development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in eye-antennal disc morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in female germ-line stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in foregut morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in formation of a compartment boundary IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in germ-line stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in germ-line stem-cell niche homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in germarium-derived egg chamber formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in glial cell fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hemocyte proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in imaginal disc-derived leg joint morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in imaginal disc-derived leg morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in imaginal disc-derived leg segmentation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in imaginal disc-derived male genitalia morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in imaginal disc-derived wing margin morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in imaginal disc-derived wing vein specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in intestinal stem cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lamellocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in larval lymph gland hemopoiesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lateral inhibition TAS
Traceable Author Statement
more info
PubMed 
involved_in leg disc morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in long-term memory IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in lymph gland development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in mesoderm development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in morphogenesis of an epithelial fold IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in motor neuron axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in muscle cell cellular homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in muscle cell fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in myoblast development IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in negative regulation of cell-cell adhesion mediated by cadherin IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of compound eye photoreceptor development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of lamellocyte differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuroblast development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuroblast fate determination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuroblast fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuroblast fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuronal stem cell population maintenance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neuronal stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oocyte localization involved in germarium-derived egg chamber formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ovarian follicle cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ovarian follicle cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ovarian follicle cell stalk formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in peripheral nervous system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of crystal cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of cardioblast cell fate specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of filopodium assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of glycolytic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of growth IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of growth IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of mitotic cell cycle TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of neuroblast proliferation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of stem cell division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to symbiont IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in retinal cell programmed cell death TAS
Traceable Author Statement
more info
PubMed 
involved_in second mitotic wave involved in compound eye morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory organ development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory organ precursor cell fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in stem cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in wing disc dorsal/ventral pattern formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
part_of CSL-Notch-Mastermind transcription factor complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of CSL-Notch-Mastermind transcription factor complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with late endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with lysosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
PubMed 

General protein information

Preferred Names
notch
Names
CG3936-PA
CG3936-PB
N-PA
N-PB
NICD
abruptex
chopped
confluens
dNotch
facet
notchoid
split
strawberry

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    3134870..3172221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057511.4NP_476859.2  notch, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476859.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P07207
    UniProtKB/TrEMBL
    M9NE67
    Related
    FBpp0070483, FBtr0070507
    Conserved Domains (10) summary
    smart00004
    Location:14761512
    NL; Domain found in Notch and Lin-12
    cd00054
    Location:449486
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00204
    Location:19782104
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00066
    Location:15191553
    Notch; LNR domain
    pfam06816
    Location:15991648
    NOD; NOTCH protein
    pfam07684
    Location:16801731
    NODP; NOTCH protein
    pfam11936
    Location:26272682
    DUF3454; Domain of unknown function (DUF3454)
    pfam12796
    Location:20222114
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:19702025
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:20172048
    ANK; ANK repeat [structural motif]
  2. NM_001258581.2NP_001245510.1  notch, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245510.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P07207
    UniProtKB/TrEMBL
    M9NE67
    Related
    FBpp0293201, FBtr0304659
    Conserved Domains (10) summary
    smart00004
    Location:14761512
    NL; Domain found in Notch and Lin-12
    cd00054
    Location:449486
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00204
    Location:19782104
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam00066
    Location:15191553
    Notch; LNR domain
    pfam06816
    Location:15991648
    NOD; NOTCH protein
    pfam07684
    Location:16801731
    NODP; NOTCH protein
    pfam11936
    Location:26272682
    DUF3454; Domain of unknown function (DUF3454)
    pfam12796
    Location:20222114
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:19702025
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:20172048
    ANK; ANK repeat [structural motif]
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