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ANXA11 annexin A11 [ Homo sapiens (human) ]

Gene ID: 311, updated on 11-Sep-2019

Summary

Official Symbol
ANXA11provided by HGNC
Official Full Name
annexin A11provided by HGNC
Primary source
HGNC:HGNC:535
See related
Ensembl:ENSG00000122359 MIM:602572
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALS23; ANX11; CAP50; CAP-50
Summary
This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, Dec 2015]
Expression
Ubiquitous expression in esophagus (RPKM 36.2), heart (RPKM 32.2) and 25 other tissues See more
Orthologs

Genomic context

See ANXA11 in Genome Data Viewer
Location:
10q22.3
Exon count:
20
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (80150889..80205808, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (81914880..81965433, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L22 pseudogene 18 Neighboring gene placenta associated 9 Neighboring gene long intergenic non-protein coding RNA 857 Neighboring gene ribosomal protein S12 pseudogene 2 Neighboring gene uncharacterized LOC100130698 Neighboring gene eukaryotic translation initiation factor 5A pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
AMYOTROPHIC LATERAL SCLEROSIS 23
MedGen: C4693381 OMIM: 617839 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
NHGRI GWA Catalog
Genome-wide association analysis reveals 12q13.3-q14.1 as new risk locus for sarcoidosis.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
MHC class II protein complex binding HDA PubMed 
RNA binding HDA PubMed 
S100 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
S100 protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphatidylethanolamine binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cytokinetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytokinetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
phagocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phagocytosis IEP
Inferred from Expression Pattern
more info
PubMed 
response to calcium ion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
response to calcium ion IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
azurophil granule IDA
Inferred from Direct Assay
more info
PubMed 
collagen-containing extracellular matrix HDA PubMed 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
melanosome IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
midbody IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
nuclear envelope NAS
Non-traceable Author Statement
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm NAS
Non-traceable Author Statement
more info
PubMed 
phagocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
specific granule IDA
Inferred from Direct Assay
more info
PubMed 
spindle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
annexin A11
Names
56 kDa autoantigen
annexin XI
annexin-11
calcyclin-associated annexin 50
epididymis secretory sperm binding protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001157.3NP_001148.1  annexin A11 isoform 1

    See identical proteins and their annotated locations for NP_001148.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (a) represents the shortest transcript. Variants a, b, c, d, and e all encode the same isoform (1).
    Source sequence(s)
    AL356095, AL513174
    Consensus CDS
    CCDS7364.1
    UniProtKB/Swiss-Prot
    P50995
    UniProtKB/TrEMBL
    Q5T0G8
    Related
    ENSP00000361305.3, ENST00000372231.7
    Conserved Domains (2) summary
    pfam00191
    Location:204269
    Annexin; Annexin
    cl27975
    Location:75194
    EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
  2. NM_001278407.2NP_001265336.1  annexin A11 isoform 1

    See identical proteins and their annotated locations for NP_001265336.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (d) differs in the 5' UTR compared to variant a. Variants a, b, c, d, and e all encode the same isoform (1).
    Source sequence(s)
    AJ278463, AK056107, AL356095, AL513174, DA558997
    Consensus CDS
    CCDS7364.1
    UniProtKB/Swiss-Prot
    P50995
    UniProtKB/TrEMBL
    Q5T0G8
    Conserved Domains (2) summary
    pfam00191
    Location:204269
    Annexin; Annexin
    cl27975
    Location:75194
    EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
  3. NM_001278408.1NP_001265337.1  annexin A11 isoform 1

    See identical proteins and their annotated locations for NP_001265337.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (e) differs in the 5' UTR compared to variant a. Variants a, b, c, d, and e all encode the same isoform (1).
    Source sequence(s)
    AJ278463, AK126287, AL356095, AL513174, BC007564
    Consensus CDS
    CCDS7364.1
    UniProtKB/Swiss-Prot
    P50995
    UniProtKB/TrEMBL
    Q5T0G8
    Conserved Domains (2) summary
    pfam00191
    Location:204269
    Annexin; Annexin
    cl27975
    Location:75194
    EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
  4. NM_001278409.2NP_001265338.1  annexin A11 isoform 2

    See identical proteins and their annotated locations for NP_001265338.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (f) contains an alternate exon compared to variant 1. This difference results in a distinct 5' UTR and causes translation initiation at a downstream start codon, compared to variant a. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AJ278463, AK301047, AL356095, AL513174
    Consensus CDS
    CCDS60576.1
    UniProtKB/Swiss-Prot
    P50995
    Related
    ENSP00000265447.5, ENST00000265447.8
    Conserved Domains (2) summary
    pfam00191
    Location:171236
    Annexin; Annexin
    cl27975
    Location:42161
    EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
  5. NM_145868.2NP_665875.1  annexin A11 isoform 1

    See identical proteins and their annotated locations for NP_665875.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (b) differs in the 5' UTR compared to variant a. Variants a, b, c, d, and e all encode the same isoform (1).
    Source sequence(s)
    AL356095, AL513174
    Consensus CDS
    CCDS7364.1
    UniProtKB/Swiss-Prot
    P50995
    UniProtKB/TrEMBL
    Q5T0G8
    Related
    ENSP00000404412.2, ENST00000422982.8
    Conserved Domains (2) summary
    pfam00191
    Location:204269
    Annexin; Annexin
    cl27975
    Location:75194
    EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
  6. NM_145869.2NP_665876.1  annexin A11 isoform 1

    See identical proteins and their annotated locations for NP_665876.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (c) differs in the 5' UTR compared to variant a. Variants a, b, c, d, and e all encode the same isoform (1).
    Source sequence(s)
    AL356095, AL513174
    Consensus CDS
    CCDS7364.1
    UniProtKB/Swiss-Prot
    P50995
    UniProtKB/TrEMBL
    Q5T0G8
    Related
    ENSP00000398610.1, ENST00000438331.5
    Conserved Domains (2) summary
    pfam00191
    Location:204269
    Annexin; Annexin
    cl27975
    Location:75194
    EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    80150889..80205808 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539736.3XP_011538038.1  annexin A11 isoform X3

    See identical proteins and their annotated locations for XP_011538038.1

    UniProtKB/Swiss-Prot
    P50995
    UniProtKB/TrEMBL
    Q5T0G8
    Conserved Domains (2) summary
    pfam00191
    Location:204269
    Annexin; Annexin
    cl27975
    Location:75194
    EBV-NA3; Epstein-Barr virus nuclear antigen 3 (EBNA-3)
  2. XM_005269741.4XP_005269798.1  annexin A11 isoform X1

    Conserved Domains (1) summary
    pfam00191
    Location:304369
    Annexin; Annexin
  3. XM_005269742.1XP_005269799.1  annexin A11 isoform X2

    See identical proteins and their annotated locations for XP_005269799.1

    Conserved Domains (1) summary
    pfam00191
    Location:204269
    Annexin; Annexin
  4. XM_006717813.2XP_006717876.1  annexin A11 isoform X2

    See identical proteins and their annotated locations for XP_006717876.1

    Conserved Domains (1) summary
    pfam00191
    Location:204269
    Annexin; Annexin
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