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ase asense [ Drosophila melanogaster (fruit fly) ]

Gene ID: 30985, updated on 10-May-2024

Summary

Official Symbol
aseprovided by FlyBase
Official Full Name
asenseprovided by FlyBase
Primary source
FLYBASE:FBgn0000137
Locus tag
Dmel_CG3258
See related
AllianceGenome:FB:FBgn0000137
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
AS-C T8; AS-C T8ase; as-T8; AS-T8; ASC; ascT8; Ase; Asense; bHLHc28; CG3258; Dmel\CG3258; EG:165H7.2; sc/T8; T1; T1a; T1A; T8
Summary
Enables DNA binding activity; protein heterodimerization activity; and protein homodimerization activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including Malpighian tubule development; generation of neurons; and negative regulation of mitotic nuclear division. Located in nucleus. Is expressed in several structures, including extended germ band embryo; head; imaginal disc; presumptive embryonic/larval nervous system; and somatic precursor cell. Orthologous to human ASCL1 (achaete-scute family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See ase in Genome Data Viewer
Location:
1B3-1B3; 1-0 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (460747..463176)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (354780..357209)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene lethal of scute Neighboring gene Pepsinogen C-like Neighboring gene Cytochrome P450 4g1 Neighboring gene ellipsoid body open

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in Malpighian tubule tip cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in central nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in chaeta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chaeta morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial cell proliferation involved in Malpighian tubule morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of mitotic nuclear division IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nervous system development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neuroblast fate determination IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in peripheral nervous system development NAS
Non-traceable Author Statement
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neurogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in regulation of neurogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sensory organ development IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
asense
Names
CG3258-PA
ase-PA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    460747..463176
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057346.5NP_476694.1  asense [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_476694.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P09775, Q541C1, Q9W5G2
    Related
    FBpp0070074
    Conserved Domains (1) summary
    pfam00010
    Location:172224
    HLH; Helix-loop-helix DNA-binding domain