ase asense [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: aseprovided by FlyBase
Official Full Name: asenseprovided by FlyBase
Primary source: FLYBASE:FBgn0000137
Locus tag: Dmel_CG3258
See related: AllianceGenome:FB:FBgn0000137
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: AS-C T8; AS-C T8ase; as-T8; AS-T8; ASC; ascT8; Ase; Asense; bHLHc28; CG3258; Dmel\CG3258; EG:165H7.2; sc/T8; T1; T1a; T1A; T8
Summary: Enables DNA binding activity; protein heterodimerization activity; and protein homodimerization activity. Contributes to RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including Malpighian tubule development; generation of neurons; and negative regulation of mitotic nuclear division. Located in nucleus. Is expressed in several structures, including extended germ band embryo; head; imaginal disc; presumptive embryonic/larval nervous system; and somatic precursor cell. Orthologous to human ASCL1 (achaete-scute family bHLH transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 1B3-1B3; 1-0 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	X	NC_004354.4 (460747..463176)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	X	NC_004354.3 (354780..357209)

Chromosome X - NC_004354.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel proneural function of Asense is integrated with the sequential actions of Delta-Notch, L'sc and Su(H) to promote the neuroepithelial to neuroblast transition.
Title: A novel proneural function of Asense is integrated with the sequential actions of Delta-Notch, L'sc and Su(H) to promote the neuroepithelial to neuroblast transition.
The Ets protein Pointed P1 represses Asense expression in type II neuroblasts by activating Tailless.
Title: The Ets protein Pointed P1 represses Asense expression in type II neuroblasts by activating Tailless.
Tailless/TLX reverts intermediate neural progenitors to stem cells driving tumourigenesis via repression of asense/ASCL1.
Title: Tailless/TLX reverts intermediate neural progenitors to stem cells driving tumourigenesis via repression of asense/ASCL1.
PntP1 is both necessary and sufficient for the suppression of Ase in type II NBs and the generation of intermediate neural progenitor cells in Drosophila larval brains
Title: Ets transcription factor Pointed promotes the generation of intermediate neural progenitors in Drosophila larval brains.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Malpighian tubule tip cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in central nervous system development	NAS Non-traceable Author Statement more info	PubMed
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell proliferation involved in Malpighian tubule morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of mitotic nuclear division	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in neuroblast fate determination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peripheral nervous system development	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neural precursor cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of neurogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sensory organ development	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed