Format

Send to:

Choose Destination

Bin1 bridging integrator 1 [ Mus musculus (house mouse) ]

Gene ID: 30948, updated on 25-Nov-2021

Summary

Official Symbol
Bin1provided by MGI
Official Full Name
bridging integrator 1provided by MGI
Primary source
MGI:MGI:108092
See related
Ensembl:ENSMUSG00000024381
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ALP-1; Amphl; SH3P9; BRAMP-2
Expression
Broad expression in cerebellum adult (RPKM 72.8), cortex adult (RPKM 65.7) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Bin1 in Genome Data Viewer
Location:
18 B1; 18 18.01 cM
Exon count:
22
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (32509671..32568793)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (32376618..32435740)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 18 NC_000084.5 (32536871..32595394)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 2 Neighboring gene excision repair cross-complementing rodent repair deficiency, complementation group 3 Neighboring gene RIKEN cDNA A830052D11 gene Neighboring gene predicted gene, 35060 Neighboring gene predicted gene, 20136

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2)  1 citation
  • Endonuclease-mediated (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase binding ISO
Inferred from Sequence Orthology
more info
 
enables actin filament binding ISO
Inferred from Sequence Orthology
more info
 
enables aspartic-type endopeptidase inhibitor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables aspartic-type endopeptidase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables chaperone binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables tau protein binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables tau protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables tau protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in T-tubule organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in T-tubule organization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in endosome to lysosome transport ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid tube assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within muscle cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of amyloid-beta formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of amyloid-beta formation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of potassium ion transmembrane transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of ventricular cardiac muscle cell action potential IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleus localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nucleus organization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of actin filament polymerization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of astrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endocytosis ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell cycle process ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of endocytosis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of heart rate by cardiac conduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in I band ISO
Inferred from Sequence Orthology
more info
 
part_of RNA polymerase II transcription repressor complex ISO
Inferred from Sequence Orthology
more info
 
located_in T-tubule IDA
Inferred from Direct Assay
more info
PubMed 
located_in T-tubule ISO
Inferred from Sequence Orthology
more info
 
located_in Z disc ISO
Inferred from Sequence Orthology
more info
 
located_in axon IDA
Inferred from Direct Assay
more info
PubMed 
located_in axon ISO
Inferred from Sequence Orthology
more info
 
located_in axon initial segment ISO
Inferred from Sequence Orthology
more info
 
located_in axon terminus ISO
Inferred from Sequence Orthology
more info
 
located_in cerebellar mossy fiber ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
colocalizes_with cytoskeleton ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
part_of lipid tube ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in node of Ranvier ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
is_active_in synapse EXP
Inferred from Experiment
more info
PubMed 
is_active_in synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in synaptic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in varicosity ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
myc box-dependent-interacting protein 1
Names
SH3 domain-containing protein 9
amphiphysin 2
amphiphysin II
amphiphysin-like protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001083334.1NP_001076803.1  myc box-dependent-interacting protein 1 isoform 2

    See identical proteins and their annotated locations for NP_001076803.1

    Status: VALIDATED

    Source sequence(s)
    AI840452, BC065160, CJ121020
    Consensus CDS
    CCDS37755.1
    UniProtKB/TrEMBL
    Q6P1B9
    Related
    ENSMUSP00000089590.6, ENSMUST00000091967.13
    Conserved Domains (2) summary
    cd07611
    Location:31241
    BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II
    cd12139
    Location:405476
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
  2. NM_001360876.1NP_001347805.1  myc box-dependent-interacting protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC126026
    Conserved Domains (2) summary
    cd07611
    Location:31272
    BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II
    cd12139
    Location:480551
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
  3. NM_009668.2NP_033798.1  myc box-dependent-interacting protein 1 isoform 1

    See identical proteins and their annotated locations for NP_033798.1

    Status: VALIDATED

    Source sequence(s)
    AI840452, AW496330, BQ573238, BU707946, CF732768, CJ121020, CO426739
    Consensus CDS
    CCDS29119.1
    UniProtKB/Swiss-Prot
    O08539
    Related
    ENSMUSP00000025239.8, ENSMUST00000025239.9
    Conserved Domains (4) summary
    cd07611
    Location:31272
    BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II
    cd12139
    Location:516587
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
    cl26247
    Location:400473
    DNA_pol3_delta2; DNA polymerase III, delta subunit
    cl26386
    Location:316490
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    32509671..32568793
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030250491.1XP_030106351.1  myc box-dependent-interacting protein 1 isoform X7

    Conserved Domains (2) summary
    cd07611
    Location:31272
    BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II
    cd12139
    Location:480551
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
  2. XM_017317916.3XP_017173405.1  myc box-dependent-interacting protein 1 isoform X10

    Conserved Domains (2) summary
    cd12139
    Location:436507
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
    cl12013
    Location:31272
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  3. XM_006525987.4XP_006526050.1  myc box-dependent-interacting protein 1 isoform X13

    Conserved Domains (2) summary
    cd12139
    Location:412483
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
    cl12013
    Location:31272
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  4. XM_006525978.5XP_006526041.1  myc box-dependent-interacting protein 1 isoform X1

    Conserved Domains (4) summary
    cd07611
    Location:31272
    BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II
    PRK14959
    Location:415488
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    cd12139
    Location:531602
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
    PRK12323
    Location:331505
    PRK12323; DNA polymerase III subunit gamma/tau
  5. XM_006525981.5XP_006526044.1  myc box-dependent-interacting protein 1 isoform X4

    Conserved Domains (2) summary
    cd07611
    Location:31272
    BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II
    cd12139
    Location:495566
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
  6. XM_006525984.5XP_006526047.1  myc box-dependent-interacting protein 1 isoform X8

    Conserved Domains (2) summary
    cd12139
    Location:451522
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
    cl12013
    Location:31272
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  7. XM_006525985.5XP_006526048.1  myc box-dependent-interacting protein 1 isoform X11

    Conserved Domains (2) summary
    cd12139
    Location:427498
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
    cl12013
    Location:31272
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  8. XM_006525988.5XP_006526051.1  myc box-dependent-interacting protein 1 isoform X14

    Conserved Domains (2) summary
    cd12139
    Location:408479
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
    cl12013
    Location:31272
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  9. XM_006525990.5XP_006526053.1  myc box-dependent-interacting protein 1 isoform X16

    Conserved Domains (2) summary
    cd12139
    Location:384455
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
    cl12013
    Location:31272
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  10. XM_006525989.5XP_006526052.1  myc box-dependent-interacting protein 1 isoform X15

    Conserved Domains (2) summary
    cd12139
    Location:393464
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
    cl12013
    Location:31272
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  11. XM_006525992.5XP_006526055.1  myc box-dependent-interacting protein 1 isoform X19

    Conserved Domains (2) summary
    cd12139
    Location:369440
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
    cl12013
    Location:31272
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
  12. XM_006525980.5XP_006526043.1  myc box-dependent-interacting protein 1 isoform X3

    Conserved Domains (4) summary
    cd07611
    Location:31241
    BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II
    PRK14959
    Location:384457
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    cd12139
    Location:500571
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
    PRK12323
    Location:300474
    PRK12323; DNA polymerase III subunit gamma/tau
  13. XM_006525986.5XP_006526049.1  myc box-dependent-interacting protein 1 isoform X12

    Conserved Domains (2) summary
    cd07611
    Location:31241
    BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II
    cd12139
    Location:420491
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
  14. XM_006525991.5XP_006526054.1  myc box-dependent-interacting protein 1 isoform X18

    Conserved Domains (2) summary
    cd07611
    Location:31241
    BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II
    cd12139
    Location:377448
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
  15. XM_006525994.5XP_006526057.1  myc box-dependent-interacting protein 1 isoform X21

    Conserved Domains (2) summary
    cd07611
    Location:31241
    BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II
    cd12139
    Location:353424
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
  16. XM_006525982.5XP_006526045.1  myc box-dependent-interacting protein 1 isoform X6

    Conserved Domains (4) summary
    cd07611
    Location:31241
    BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II
    PRK14959
    Location:369442
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    cd12139
    Location:485556
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
    PRK12323
    Location:285459
    PRK12323; DNA polymerase III subunit gamma/tau
  17. XM_030250493.2XP_030106353.1  myc box-dependent-interacting protein 1 isoform X9

    Conserved Domains (2) summary
    cd07611
    Location:31241
    BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II
    cd12139
    Location:449520
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
  18. XM_017317917.3XP_017173406.1  myc box-dependent-interacting protein 1 isoform X17

    Conserved Domains (2) summary
    cd07611
    Location:31241
    BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II
    cd12139
    Location:381452
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
  19. XM_006525993.4XP_006526056.1  myc box-dependent-interacting protein 1 isoform X20

    See identical proteins and their annotated locations for XP_006526056.1

    UniProtKB/Swiss-Prot
    O08539
    Related
    ENSMUSP00000157259.2, ENSMUST00000234857.2
    Conserved Domains (2) summary
    cd07611
    Location:31241
    BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II
    cd12139
    Location:362433
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
  20. XM_006525995.4XP_006526058.1  myc box-dependent-interacting protein 1 isoform X22

    Related
    ENSMUSP00000156976.2, ENSMUST00000234496.2
    Conserved Domains (2) summary
    cd07611
    Location:31241
    BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II
    cd12139
    Location:338409
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
  21. XM_006525979.3XP_006526042.1  myc box-dependent-interacting protein 1 isoform X2

    Conserved Domains (4) summary
    cd07611
    Location:26267
    BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II
    PRK14959
    Location:410483
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    cd12139
    Location:526597
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
    PRK12323
    Location:326500
    PRK12323; DNA polymerase III subunit gamma/tau
  22. XM_030250490.2XP_030106350.1  myc box-dependent-interacting protein 1 isoform X5

    Conserved Domains (4) summary
    cd07611
    Location:26236
    BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II
    PRK14959
    Location:379452
    PRK14959; DNA polymerase III subunits gamma and tau; Provisional
    cd12139
    Location:495566
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
    PRK12323
    Location:295469
    PRK12323; DNA polymerase III subunit gamma/tau
  23. XM_030250497.2XP_030106357.1  myc box-dependent-interacting protein 1 isoform X23

    Conserved Domains (2) summary
    cd07611
    Location:26236
    BAR_Amphiphysin_I_II; The Bin/Amphiphysin/Rvs (BAR) domain of Amphiphysin I and II
    cd12139
    Location:333404
    SH3_Bin1; Src Homology 3 domain of Bridging integrator 1 (Bin1), also called Amphiphysin-2
Support Center