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Usp21 ubiquitin specific peptidase 21 [ Mus musculus (house mouse) ]

Gene ID: 30941, updated on 8-Feb-2024

Summary

Official Symbol
Usp21provided by MGI
Official Full Name
ubiquitin specific peptidase 21provided by MGI
Primary source
MGI:MGI:1353665
See related
Ensembl:ENSMUSG00000053483 AllianceGenome:MGI:1353665
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Usp16; Usp23; ESTM28
Summary
Enables thiol-dependent deubiquitinase and transcription coactivator activity. Involved in histone deubiquitination and positive regulation of transcription, DNA-templated. Predicted to be located in cytosol; nucleoplasm; and plasma membrane. Predicted to be active in cytoplasm. Is expressed in left lung; right lung; and submandibular gland primordium. Orthologous to human USP21 (ubiquitin specific peptidase 21). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in limb E14.5 (RPKM 28.1), CNS E14 (RPKM 27.0) and 28 other tissues See more
Orthologs
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Genomic context

See Usp21 in Genome Data Viewer
Location:
1 H3; 1 79.3 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171109523..171115534, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171281949..171287961, complement)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3 Neighboring gene protoporphyrinogen oxidase Neighboring gene STARR-positive B cell enhancer mm9_chr1:173211225-173211526 Neighboring gene STARR-positive B cell enhancer mm9_chr1:173211857-173212158 Neighboring gene ubiquitin-fold modifier conjugating enzyme 1 Neighboring gene STARR-seq mESC enhancer starr_03026 Neighboring gene STARR-seq mESC enhancer starr_03027 Neighboring gene ribosomal protein L27, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (5)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type peptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables cysteine-type peptidase activity ISO
Inferred from Sequence Orthology
more info
 
enables deNEDDylase activity ISO
Inferred from Sequence Orthology
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within chromatin organization IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in protein deubiquitination IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in transcription initiation-coupled chromatin remodeling IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
ubiquitin carboxyl-terminal hydrolase 21
Names
deubiquitinating enzyme 21
ubiquitin specific protease 21
ubiquitin specific protease 23
ubiquitin thioesterase 21
ubiquitin thiolesterase 21
ubiquitin-specific-processing protease 21
NP_038947.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013919.4NP_038947.2  ubiquitin carboxyl-terminal hydrolase 21

    Status: VALIDATED

    Source sequence(s)
    AF177759, AK011148, BP770216, BY110597
    Consensus CDS
    CCDS35774.1
    UniProtKB/Swiss-Prot
    Q9D0R1, Q9QZL6
    UniProtKB/TrEMBL
    E9PUE2
    Related
    ENSMUSP00000064002.6, ENSMUST00000065941.12
    Conserved Domains (1) summary
    pfam00443
    Location:212556
    UCH; Ubiquitin carboxyl-terminal hydrolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    171109523..171115534 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)