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Slamf6 SLAM family member 6 [ Mus musculus (house mouse) ]

Gene ID: 30925, updated on 8-Feb-2024

Summary

Official Symbol
Slamf6provided by MGI
Official Full Name
SLAM family member 6provided by MGI
Primary source
MGI:MGI:1353620
See related
Ensembl:ENSMUSG00000015314 AllianceGenome:MGI:1353620
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
KAL1; NTBA; KAL1b; Ly108; NTB-A; SF2000
Summary
Involved in natural killer cell differentiation and natural killer cell proliferation. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Predicted to be active in external side of plasma membrane. Orthologous to human SLAMF6 (SLAM family member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 5.3), spleen adult (RPKM 3.2) and 4 other tissues See more
Orthologs
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Genomic context

See Slamf6 in Genome Data Viewer
Location:
1 H3; 1 79.54 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (171745002..171776525)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (171917458..171948958)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CD84 antigen Neighboring gene predicted gene, 51686 Neighboring gene STARR-seq mESC enhancer starr_03042 Neighboring gene STARR-seq mESC enhancer starr_03043 Neighboring gene STARR-seq mESC enhancer starr_03044 Neighboring gene predicted gene 52845 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:173849407-173849647 Neighboring gene STARR-positive B cell enhancer ABC_E3330 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:173851483-173851687 Neighboring gene predicted gene, 37065 Neighboring gene STARR-seq mESC enhancer starr_03046 Neighboring gene STARR-positive B cell enhancer ABC_E5850 Neighboring gene VISTA enhancer mm1677 Neighboring gene VANGL planar cell polarity 2 Neighboring gene STARR-positive B cell enhancer ABC_E9498 Neighboring gene nescient helix loop helix 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (6)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
SLAM family member 6
Names
lymphocyte antigen 108

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347186.1NP_001334115.1  SLAM family member 6 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC091523, BC030031
    Consensus CDS
    CCDS83638.1
    UniProtKB/Swiss-Prot
    C6ESQ1, Q9ET39, Q9ET40
    UniProtKB/TrEMBL
    Q18PJ0, Q18PJ2
    Related
    ENSMUSP00000141448.2, ENSMUST00000195656.6
  2. NM_001347187.1NP_001334116.1  SLAM family member 6 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AC091523, EU591721
    Consensus CDS
    CCDS83639.1
    UniProtKB/TrEMBL
    Q18PJ2
    Related
    ENSMUSP00000141944.2, ENSMUST00000194561.2
  3. NM_030710.3NP_109635.1  SLAM family member 6 isoform 1 precursor

    See identical proteins and their annotated locations for NP_109635.1

    Status: VALIDATED

    Source sequence(s)
    AC091523
    Consensus CDS
    CCDS15504.1
    UniProtKB/TrEMBL
    Q18PG5, Q18PJ2
    Related
    ENSMUSP00000130610.2, ENSMUST00000171330.7
    Conserved Domains (1) summary
    cl11960
    Location:44142
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    171745002..171776525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006496884.5XP_006496947.1  SLAM family member 6 isoform X1

    UniProtKB/TrEMBL
    Q18PJ2
    Conserved Domains (1) summary
    cl11960
    Location:44142
    Ig; Immunoglobulin domain
  2. XM_006496886.5XP_006496949.1  SLAM family member 6 isoform X2

    UniProtKB/TrEMBL
    Q18PJ2
    Conserved Domains (1) summary
    cl11960
    Location:25123
    Ig; Immunoglobulin domain
  3. XM_011238825.3XP_011237127.1  SLAM family member 6 isoform X3

RNA

  1. XR_373611.5 RNA Sequence