Angptl3 angiopoietin-like 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Angptl3provided by MGI
Official Full Name: angiopoietin-like 3provided by MGI
Primary source: MGI:MGI:1353627
See related: Ensembl:ENSMUSG00000028553 AllianceGenome:MGI:1353627
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: hypl
Summary: This gene encodes a member of the angiopoietin-like family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may inhibit triglyceride metabolism. Homozygous knockout mice for this gene exhibit reduced plasma lipid concentrations, including reduced plasma triglyceride concentrations, and enhanced activity of enzymes involved in triglyceride metabolism. [provided by RefSeq, Aug 2015]
Expression: Biased expression in liver E18 (RPKM 129.0), liver adult (RPKM 39.9) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 C6; 4 45.6 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (98919191..98926429)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (99030954..99038192)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ANGPTL3 is a novel HDL component that regulates HDL function.
Title: ANGPTL3 is a novel HDL component that regulates HDL function.
The influence of angiopoietin-like protein 3 on macrophages polarization and its effect on the podocyte EMT in diabetic nephropathy.
Title: The influence of angiopoietin-like protein 3 on macrophages polarization and its effect on the podocyte EMT in diabetic nephropathy.
METTL3 regulates N6-methyladenosine modification of ANGPTL3 mRNA and potentiates malignant progression of stomach adenocarcinoma.
Title: METTL3 regulates N6-methyladenosine modification of ANGPTL3 mRNA and potentiates malignant progression of stomach adenocarcinoma.
The Fibrinogen-like Domain of ANGPTL3 Facilitates Lipolysis in 3T3-L1 Cells by Activating the Intracellular Erk Pathway.
Title: The Fibrinogen-like Domain of ANGPTL3 Facilitates Lipolysis in 3T3-L1 Cells by Activating the Intracellular Erk Pathway.
ANGPTL3 impacts proteinuria and hyperlipidemia in primary nephrotic syndrome.
Title: ANGPTL3 impacts proteinuria and hyperlipidemia in primary nephrotic syndrome.
Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8.
Title: Angiopoietin-like 3 inhibition of endothelial lipase is not modulated by angiopoietin-like 8.
Antisense oligonucleotide-mediated inhibition of angiopoietin-like protein 3 increases reverse cholesterol transport in mice.
Title: Antisense oligonucleotide-mediated inhibition of angiopoietin-like protein 3 increases reverse cholesterol transport in mice.
Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance.
Title: Angiopoietin-like protein 3 governs LDL-cholesterol levels through endothelial lipase-dependent VLDL clearance.
Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3.
Title: Lipid nanoparticle-mediated codelivery of Cas9 mRNA and single-guide RNA achieves liver-specific in vivo genome editing of Angptl3.
Angiopoietin-like-3 knockout protects against glomerulosclerosis in murine adriamycin-induced nephropathy by attenuating podocyte loss.
Title: Angiopoietin-like-3 knockout protects against glomerulosclerosis in murine adriamycin-induced nephropathy by attenuating podocyte loss.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (7)
Spontaneous (1) 1 citation
Targeted (8) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info
enables growth factor activity	ISO Inferred from Sequence Orthology more info
enables heparin binding	IEA Inferred from Electronic Annotation more info
enables integrin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables phospholipase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables phospholipase inhibitor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in acylglycerol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in acylglycerol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in artery morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	ISS Inferred from Sequence or Structural Similarity more info
involved_in cholesterol homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cholesterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cholesterol homeostasis	ISO Inferred from Sequence Orthology more info
involved_in cholesterol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in cholesterol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in glycerol metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glycerol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in lipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in lipid storage	IEA Inferred from Electronic Annotation more info
involved_in lipid storage	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of lipoprotein lipase activity	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of lipoprotein lipase activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of phospholipase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of phospholipase activity	ISO Inferred from Sequence Orthology more info
involved_in phospholipid catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in phospholipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in phospholipid homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phospholipid homeostasis	ISO Inferred from Sequence Orthology more info
involved_in phospholipid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of angiogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of lipid catabolic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of lipid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of lipid metabolic process	NAS Non-traceable Author Statement more info	PubMed
involved_in response to hormone	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
involved_in triglyceride homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in triglyceride homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within triglyceride homeostasis	ISO Inferred from Sequence Orthology more info
involved_in triglyceride metabolic process	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in collagen-containing extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular region	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: angiopoietin-related protein 3

Names: angiopoietin-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_013913.4 → NP_038941.1 angiopoietin-related protein 3 preproprotein

See identical proteins and their annotated locations for NP_038941.1

Status: REVIEWED

Source sequence(s)

AK149450, AL935325, BY137245

Consensus CDS

CCDS38817.1

UniProtKB/Swiss-Prot

Q9R182

UniProtKB/TrEMBL

Q3UEF5

Related

ENSMUSP00000030280.7, ENSMUST00000030280.7

Conserved Domains (2) summary

cd00087
Location:241 → 453

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...

cl02488
Location:34 → 191

SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...