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Angptl3 angiopoietin-like 3 [ Mus musculus (house mouse) ]

Gene ID: 30924, updated on 14-May-2024

Summary

Official Symbol
Angptl3provided by MGI
Official Full Name
angiopoietin-like 3provided by MGI
Primary source
MGI:MGI:1353627
See related
Ensembl:ENSMUSG00000028553 AllianceGenome:MGI:1353627
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
hypl
Summary
This gene encodes a member of the angiopoietin-like family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may inhibit triglyceride metabolism. Homozygous knockout mice for this gene exhibit reduced plasma lipid concentrations, including reduced plasma triglyceride concentrations, and enhanced activity of enzymes involved in triglyceride metabolism. [provided by RefSeq, Aug 2015]
Expression
Biased expression in liver E18 (RPKM 129.0), liver adult (RPKM 39.9) and 2 other tissues See more
Orthologs
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Genomic context

See Angptl3 in Genome Data Viewer
Location:
4 C6; 4 45.6 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (98919191..98926429)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (99030954..99038192)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 12851 Neighboring gene STARR-positive B cell enhancer ABC_E151 Neighboring gene STARR-seq mESC enhancer starr_10862 Neighboring gene ubiquitin specific peptidase 1 Neighboring gene dedicator of cytokinesis 7 Neighboring gene STARR-seq mESC enhancer starr_10863 Neighboring gene ribosomal protein S4, X-linked pseudogene Neighboring gene STARR-seq mESC enhancer starr_10865 Neighboring gene STARR-positive B cell enhancer mm9_chr4:98849339-98849639 Neighboring gene STARR-seq mESC enhancer starr_10866 Neighboring gene autophagy related 4C, cysteine peptidase Neighboring gene predicted gene 10305

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables growth factor activity ISO
Inferred from Sequence Orthology
more info
 
enables heparin binding IEA
Inferred from Electronic Annotation
more info
 
enables integrin binding ISO
Inferred from Sequence Orthology
more info
 
enables phospholipase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in acylglycerol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in acylglycerol homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in artery morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
 
involved_in cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cholesterol homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cholesterol homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in cholesterol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in glycerol metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in lipid homeostasis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in lipid storage ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of lipoprotein lipase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of phospholipase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of phospholipase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of phospholipase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phospholipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in phospholipid homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipid homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in phospholipid metabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipid catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of lipid metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in triglyceride homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within triglyceride homeostasis ISO
Inferred from Sequence Orthology
more info
 
involved_in triglyceride metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
is_active_in collagen-containing extracellular matrix IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in early endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
angiopoietin-related protein 3
Names
angiopoietin-like protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013913.4NP_038941.1  angiopoietin-related protein 3 preproprotein

    See identical proteins and their annotated locations for NP_038941.1

    Status: REVIEWED

    Source sequence(s)
    AK149450, AL935325, BY137245
    Consensus CDS
    CCDS38817.1
    UniProtKB/Swiss-Prot
    Q9R182
    UniProtKB/TrEMBL
    Q3UEF5
    Related
    ENSMUSP00000030280.7, ENSMUST00000030280.7
    Conserved Domains (2) summary
    cd00087
    Location:241453
    FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
    cl02488
    Location:34191
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    98919191..98926429
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)