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Acp4 acid phosphatase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308569, updated on 18-Sep-2024

Summary

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Official Symbol
Acp4provided by RGD
Official Full Name
acid phosphatase 4provided by RGD
Primary source
RGD:1308270
See related
EnsemblRapid:ENSRNOG00000021659 AllianceGenome:RGD:1308270
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Acpt
Summary
Predicted to enable acid phosphatase activity; protein tyrosine phosphatase activity; and receptor tyrosine kinase binding activity. Predicted to be involved in several processes, including negative regulation of ERBB4 signaling pathway; negative regulation of cellular protein metabolic process; and regulation of neuronal synaptic plasticity. Located in postsynaptic membrane. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1J. Orthologous to human ACP4 (acid phosphatase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 76.2), Brain (RPKM 48.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q22
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (103872922..103888418, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (94736376..94751871, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (100226311..100234536, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD88 Neighboring gene small nucleolar RNA, C/D box 88B Neighboring gene Friend virus susceptibility 1 Neighboring gene formyl peptide receptor-related sequence 4 Neighboring gene small integral membrane protein 47 Neighboring gene G protein-coupled receptor 32 Neighboring gene ribosome production factor 1, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Recessive Mutations in ACPT, Encoding Testicular Acid Phosphatase, Cause Hypoplastic Amelogenesis Imperfecta. Seymen F, et al. Am J Hum Genet, 2016 Nov 3. PMID 27843125, Free PMC Article
  2. Regulation of ErbB4 phosphorylation and cleavage by a novel histidine acid phosphatase. Fleisig H, et al. Neuroscience, 2004. PMID 15219672
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acid phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein tyrosine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein tyrosine phosphatase activity ISO
Inferred from Sequence Orthology
more info
  
enables receptor tyrosine kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of ERBB4 signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of ERBB4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in odontogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
involved_in peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of neuronal synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neuronal synaptic plasticity ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in lysosome IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
testicular acid phosphatase
Names
acid phosphatase, testicular
NP_001100980.2
NP_001388455.1
XP_008757591.1
XP_038967846.1
XP_038967865.1
XP_038967876.1
XP_038967884.1
XP_063117957.1
XP_063117984.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107510.2 → NP_001100980.2  testicular acid phosphatase isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    Related
    ENSRNOP00000038370.6, ENSRNOT00000032200.7

  2. NM_001401526.1 → NP_001388455.1  testicular acid phosphatase isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2KB67, A0A8I6GH32
    Related
    ENSRNOP00000089271.1, ENSRNOT00000094074.2
    Conserved Domains (1) summary
    cd07061
    Location:22 → 301
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    103872922..103888418 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039111937.2 → XP_038967865.1  testicular acid phosphatase isoform X2

    UniProtKB/TrEMBL
    A0A0G2KB67, A0A8I6GH32
    Conserved Domains (1) summary
    cd07061
    Location:22 → 301
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

  2. XM_039111918.2 → XP_038967846.1  testicular acid phosphatase isoform X2

    UniProtKB/TrEMBL
    A0A0G2KB67, A0A8I6GH32
    Conserved Domains (1) summary
    cd07061
    Location:22 → 301
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

  3. XM_063261887.1 → XP_063117957.1  testicular acid phosphatase isoform X1

    UniProtKB/TrEMBL
    A0A0G2KB67
    Related
    ENSRNOP00000075674.2, ENSRNOT00000079199.3

  4. XM_063261914.1 → XP_063117984.1  testicular acid phosphatase isoform X6

  5. XM_039111956.2 → XP_038967884.1  testicular acid phosphatase isoform X5

    Conserved Domains (1) summary
    cd07061
    Location:32 → 316
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

  6. XM_039111948.2 → XP_038967876.1  testicular acid phosphatase isoform X4

    Conserved Domains (1) summary
    cd07061
    Location:32 → 316
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

  7. XM_008759369.4 → XP_008757591.1  testicular acid phosphatase isoform X3

    UniProtKB/TrEMBL
    D4AD24
    Conserved Domains (1) summary
    cd07061
    Location:32 → 316
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction

RNA

  1. XR_010052086.1 RNA Sequence

  2. XR_005505469.2 RNA Sequence

  3. XR_005505467.2 RNA Sequence

  4. XR_005505470.2 RNA Sequence

  5. XR_005505466.2 RNA Sequence

  6. XR_005505471.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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